Hepatic Drug Metabolism in Rats: Impairment in a Dirty Environment

No abstract is available for this paper.

• Publication year

  1973

• Venue

  Science

• Publication date

  1973-03-02

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1126/science.179.4076.896PMID 4687785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex and strain differences in basal and induced aniline hydroxylase and ethylmorphine N-demethylase activities from domestic and wild rats.

  1969cited by this paper
• Factors altering the responsiveness of mice to hexobarbital.

  1968cited by this paper
• Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding

  1967cited by this paper
• Chronic Toxicity of Ammonia Fumes by Inhalation.∗

  1952cited by this paper

• Housing and Environment

  2020cites this paper
• Metabolic, Traumatic, and Miscellaneous Diseases

  2020cites this paper
• Micro- and Macroenvironmental Conditions and Stability of Terrestrial Models.

  2019cites this paper
• Recording Field Potentials and Synaptic Plasticity From Freely Behaving Rodents

  2018cites this paper
• THE NATIONAL ACADEMIES PRESS

  2017cites this paper
• Influence of sampling procedure, sampling location and skin contamination on skatole and indole concentrations in adipose tissue of pigs.

  2016cites this paper
• Design and Management of Research Facilities

  2015cites this paper
• Management of organic entire male pigs - boar taint and animal welfare issues

  2015cites this paper
• Exogenous influences on skatole formation in the pig

  2015cites this paper
• Guía para el Cuidado y Uso de los Animales de Laboratorio Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council Edicion Mexicana auspiciada por la Academia Nacional De Medicina. 1999. Copyright National Academy Press, Washington, D.C. 1996

  2014cites this paper
• Processing and treatment of corncob bedding affects cage-change frequency for C57BL/6 mice.

  2012cites this paper
• Impact of the Biotic and Abiotic Environment on Animal Experiments

  2010cites this paper
• Environmental Considerations for Research Animals

  2009cites this paper
• Utility of recycled bedding for laboratory rodents.

  2009cites this paper
• Housing, care and environmental factors

  2007cites this paper
• The Use of Laboratory Animals in Toxicology Research

  2007cites this paper
• Potential for unintended consequences of environmental enrichment for laboratory animals and research results.

  2005cites this paper
• Alteration of the disruptive effect of fenfluramine on food consumption in the rat by repeated post-session administration of d-amphetamine

  2004cites this paper
• Chapter 21 – Design and Management of Animal Facilities

  2002cites this paper
• Intraocular pressure in genetically distinct mice: an update and strain survey

  2001cites this paper
• Anforderungen an die Narkosevorbereitung und -durchführung im Rahmen von experimentalchirurgischen Eingriffen an Versuchstieren

  2000cites this paper
• Biological Variation, Reproducibility, and Predictability of Experimental Research in Animals

  1999cites this paper
• Influence of aromatic components from pig manure on odour and flavour of cooked chicken meat.

  1999cites this paper
• Guide for the Care and Use of Laboratory Animals

  1996cites this paper
• Influence of Keeping Pigs Heavily Fouled with Faeces plus Urine on Skatole and Indole Concentration (Boar Taint) in Subcutaneous Fat

  1995cites this paper
• Influence of stocking rate and faeces deposition in the pen at different temperatures on skatole concentration (boar taint) in subcutaneous fat

  1994cites this paper
• An evaluation of intra-cage ventilation in three animal caging systems.

  1989cites this paper
• Factors Modifying Toxicity

  1987cites this paper
• Anesthesia and surgery of laboratory animals.

  1987cites this paper
• La gestion sanitaire des élevages de rongeurs utilisés en recherche biomédicale: III. Le programme de surveillance des infections.

  1986cites this paper
• La gestion sanitaire des élevages de rongeurs utilisés en recherche biomédicale: I. La nécessité de disposer d'animaux homogènes dans leur réaction.

  1986cites this paper
• The effect of previous d-amphetamine treatment on the disposition and lethality of fenfluramine in the rat.

  1985cites this paper
• Effects of ammonia on selected hepatic microsomal enzyme activity in mice

  1985cites this paper
• Effect of bedding changes and room ventilation rates on blood and brain ammonia levels in normal rats and rats with portacaval shunts.

  1984cites this paper
• Ammonia: its effects on biological systems, metabolic hormones, and reproduction.

  1984cites this paper
• The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung.

  1984cites this paper
• Chapter 17 – Design and Management of Animal Facilities

  1984cites this paper
• Intercurrent disease and environmental variables in rodent toxicology studies.

  1983cites this paper
• Localized and systemic effects of environmental ammonia in rats.

  1983cites this paper
• Design and Management of Research Facilities for Mice

  1983cites this paper
• ENVIRONMENTAL EFFECTS ON ANIMALS USED IN BIOMEDICAL RESEARCH

  1982cites this paper
• Evaluation of a chemical scrubber for the removal of gaseous contaminants from recycled air.

  1981cites this paper
• Barbiturate sleeptime in mice exposed to autoclaved or unautoclaved wood beddings.

  1981cites this paper
• The role of the hepatic microsomal electron-transport system in the development of metabolic tolerance from repeated oral methadone administration in mice.

  1980cites this paper
• Effect of repeated oral propoxyphene administration on analgesia, toxicity and microsomal metabolism in the mouse.

  1980cites this paper
• Physical dependence on ethanol: methodological considerations.

  1980cites this paper
• Tolerance to methadone lethality and microsomal enzyme induction in mice tolerant to and dependent on morphine.

  1980cites this paper
• Effect of the route of administration on microsomal enzyme induction following repeated administration of methadone in the mouse.

  1979cites this paper
• Bioisomerization of lindane in rats.

  1979cites this paper
• Additional metabolic correlates of 1-alpha-acetylmethadol (LAAM)-induced cellular tolerance and physical dependence: the role of the hepatic microsomal electron transport system.

  1979cites this paper
• Comparison of hepatic microsomal enzyme induction by methadone, phenobarbital and 3-methylcholanthrene in the mouse.

  1979cites this paper
• Facilitation of opiate-and enkephalin-induced motor activity in the mouse by phenytoin sodium and carbamazepine

  1979cites this paper
• Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM.

  1979cites this paper
• Selected aspects of animal husbandry and good laboratory practices.

  1979cites this paper
• Acute inhibition of oxidative drug metabolism by propoxyphene (Darvon).

  1979cites this paper
• The mechanism of induction of the microsomal drug hydroxylating system in rat liver by phenobarbital.

  1979cites this paper
• Chapter 8 – Housing to Control Research Variables

  1979cites this paper
• Effects of chronic parenteral carbohydrate administration on hepatic drug metabolism in the rat.

  1979cites this paper
• Standard laboratory procedures.

  1978cites this paper
• Basic principles in selecting animal species for research projects.

  1978cites this paper
• Diet and cell growth modulation by ammonia.

  1978cites this paper
• The degranulation test. Six tests for carcinogenicity.

  1978cites this paper
• Variations in hepatic microsomal drug metabolism in C57Bl/6 mice from three different suppliers.

  1978cites this paper
• Clinical assessment of laboratory rodents on long term bioassay studies.

  1977cites this paper
• Sudden toxicity of methadone in monkeys: behavioral and electrophysiological evidence.

  1977cites this paper
• Mixed function monooxygenase of fish as an indicator of pollution of aquatic environment by industrial effluent

  1976cites this paper
• Species differences in the effects of chronic, oral administration of methadone on oxidative drug metabolism.

  1976cites this paper
• Airborne transmission of polyoma virus.

  1976cites this paper
• Environmental and genetic factors affecting the response of laboratory animals to drugs.

  1976cites this paper
• The research animal and the significance of a health monitoring program.

  1976cites this paper
• [The laboratory animal and its housing for investigations of drugs and feed additives].

  1975cites this paper
• Effect of dietary dieldrin on the liver and drug metabolism in the female Swiss-Vancouver mouse.

  1975cites this paper
• Microsomal mixed-function oxidase activity and senescence-I. Hexobarbital sleep time and induction of components of the hepatic microsomal enzyme system in rats of different ages.

  1975cites this paper
• Comparative effects of p,p'-DDT and pentobarbital on hepatic microsomal enzymes in young quail, chicks and ducklings.

  1975cites this paper
• Microsomal enzyme induction by methadone and its implications on tolerance to methadone lethality

  1975cites this paper
• Pharmacogenetics.

  1975cites this paper
• [Environmental effect on metabolism of exogenous molecules in liver microsomes].

  1974cites this paper
• Alterations in hepatocytes after manipulation of the diet: copper, zinc and cadmium interactions.

  1974cites this paper
• Factors causing interindividual variations of drug concentrations in blood

  1974cites this paper
• Post-mortem loss of hepatic microsomal mixed function oxygenases.

  1974cites this paper
• Comparative stimulatory effects of four phenothiazines on hepatic microsomal enzymes.

  1974cites this paper
• Environmental modification of mammalian drug metabolism and biological response.

  1974cites this paper
• [Consequences of insecticide metabolism on cellular energy pathways].

  1974cites this paper
• Effects of various centrally active drugs on hepatic microsomal enzymes: a comparative study.

  1973cites this paper
• The Economics of Environmental Policy

  1973cites this paper
• Factors involved in increased protein synthesis in rat kidney after administration of DDT.

  1973cites this paper