Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  JCI Insight

• Publication date

  2017-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/jci.insight.91810PMID 28614798PMCID PMC5470891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Faculty of 1000 evaluation for Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

  2017cited by this paper
• Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

  2016cited by this paper
• Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition.

  2016influential reference
• Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation “Memories”

  2016cited by this paper
• Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes

  2016cited by this paper
• DNA Methylation in Cancer and Aging.

  2016cited by this paper
• Knockdown of DNMT1 and DNMT3a Promotes the Angiogenesis of Human Mesenchymal Stem Cells Leading to Arterial Specific Differentiation

  2016cited by this paper
• Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

  2016cited by this paper
• TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts.

  2015cited by this paper
• PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

  2015cited by this paper
• Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.

  2015cited by this paper
• miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.

  2015cited by this paper
• Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.

  2014cited by this paper
• c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart

  2014cited by this paper
• Anti‐Inflammatory Peptides From Cardiac Progenitors Ameliorate Dysfunction After Myocardial Infarction

  2014cited by this paper
• Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.

  2014cited by this paper
• Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 Promoter In Vitro and In Vivo

  2014cited by this paper
• c-kit+ Cells Minimally Contribute Cardiomyocytes to the Heart

  2014cited by this paper
• Regulation of Cardiac Expression of the Diabetic Marker MicroRNA miR-29

  2014cited by this paper
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

  2014cited by this paper
• DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.

  2014cited by this paper
• Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart

  2014cited by this paper
• Circulating miR-29a, among other up-regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy.

  2014cited by this paper
• Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart

  2013cited by this paper
• Cell Therapy for Heart Failure: A Comprehensive Overview of Experimental and Clinical Studies, Current Challenges, and Future Directions

  2013cited by this paper
• Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.

  2013cited by this paper
• Aza-induced cardiomyocyte differentiation of P19 EC-cells by epigenetic co-regulation and ERK signaling.

  2013cited by this paper
• Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells.

  2012cited by this paper
• miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.

  2012cited by this paper
• Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.

  2011cited by this paper
• Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

  2011cited by this paper
• Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia

  2011cited by this paper
• Sca-1+ Cardiac Stem Cells Mediate Acute Cardioprotection via Paracrine Factor SDF-1 following Myocardial Ischemia/Reperfusion

  2011cited by this paper
• Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell–Derived Mesoderm

  2011cited by this paper
• MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

  2011cited by this paper
• Heart regeneration

  2011cited by this paper
• The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical Wnt pathway and induces apoptosis in human non-small-cell lung cancer.

  2011cited by this paper
• Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

  2011cited by this paper
• Cardiomyogenic Potential of C-Kit+–Expressing Cells Derived From Neonatal and Adult Mouse Hearts

  2010cited by this paper
• Epigenetic Alteration of the Wnt Inhibitory Factor-1 Promoter Is Common and Occurs in Advanced Stage of Tunisian Nasopharyngeal Carcinoma

  2010cited by this paper
• Active Wnt signaling in response to cardiac injury

  2010cited by this paper
• Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology

  2009influential reference
• Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

  2008cited by this paper
• Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

  2008influential reference
• β-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation

  2008influential reference
• The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.

  2007cited by this paper
• MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

  2007cited by this paper
• Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

  2007cited by this paper
• Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis

  2006cited by this paper
• Transient Down-regulation of DNMT1 Methyltransferase Leads to Activation and Stable Hypomethylation of MAGE-A1 in Melanoma Cells*

  2006cited by this paper
• Epigenetic Inactivation of Wnt Inhibitory Factor-1 Plays an Important Role in Bladder Cancer through Aberrant Canonical Wnt/β-Catenin Signaling Pathway

  2006cited by this paper
• Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

  2005cited by this paper
• Cardiac Muscle Plasticity in Adult and Embryo by Heart‐Derived Progenitor Cells

  2004cited by this paper
• Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

  2003cited by this paper
• Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association.

  2002cited by this paper
• Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association

  2002cited by this paper

• Targeted knockdown of DNA methyltransferase 3a (DNMT3a) unlocks dedifferentiation and neurogenic potential in mouse retinal Müller glia

  2025cites this paper
• Transient DNA methyltransferase 3a (DNMT3a) Inhibition Unlocks dedifferentiation and Neurogenic Potential in Mouse Retinal Müller Glia

  2025cites this paper
• Persistent lineage plasticity driving lung cancer development and progression

  2025cites this paper
• Epigenetic Mechanisms in Heart Diseases

  2025cites this paper
• Loss-of-function variant in SPIN4 causes an X-linked overgrowth syndrome

  2023cites this paper
• The Role of Clonal Hematopoiesis of Indeterminant Potential and DNA (Cytosine-5)-Methyltransferase Dysregulation in Pulmonary Arterial Hypertension and Other Cardiovascular Diseases

  2023cites this paper
• Cigarette smoke extract affects methylation status and attenuates Sca-1 expression of mouse endothelial progenitor cell in vitro

  2021cites this paper
• Aortic root dilatation and dilated cardiomyopathy in an adult with Tatton‐Brown‐Rahman syndrome

  2021cites this paper
• Increased prostaglandin-D2 in male but not female STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation

  2020cites this paper
• Ectopic release of nitric oxide modulates the onset of cardiac development in avian model

  2020cites this paper
• Increased prostaglandin-D2 in male STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation

  2020influential citation
• Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase

  2019cites this paper
• The Beneficial Effects of UM206 on Wound Healing After Myocardial Infarction in Mice Are Lost in Follow-Up Experiments

  2019cites this paper
• Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis

  2019cites this paper
• Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs)

  2019cites this paper
• microRNAs and cardiac stem cells in heart development and disease.

  2019cites this paper