Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial

Background:Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer.Methods:Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed.Results:Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses (P=0.01 and P=0.03, respectively).Conclusion:Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-specific survival in patients with endometrial cancer.

• Publication year

  2013

• Venue

  British Journal of Cancer

• Publication date

  2013-06-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/bjc.2013.282PMID 23764750PMCID 3708572
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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