Induction of the Paraoxonase-1 Gene Expression by Resveratrol

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2004-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.ATV.0000146530.24736.cePMID 15458977
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism

  2004cited by this paper
• Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene

  2004cited by this paper
• Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.

  2003cited by this paper
• Low Paraoxonase Activity Predicts Coronary Events in the Caerphilly Prospective Study

  2003cited by this paper
• Resveratrol: from grapevines to mammalian biology

  2003cited by this paper
• Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats.

  2003cited by this paper
• The aryl hydrocarbon receptor and its xenobiotic ligands: a fundamental trigger for cardiovascular diseases.

  2003cited by this paper
• Absorption of three wine-related polyphenols in three different matrices by healthy subjects.

  2003cited by this paper
• Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation: Antiatherogenic Properties of Mediterranean Diet Phytochemicals

  2003cited by this paper
• Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.

  2003cited by this paper
• Decreased Atherosclerotic Lesion Formation in Human Serum Paraoxonase Transgenic Mice

  2002cited by this paper
• Antioxidant vitamins and lipid therapy: end of a long romance?

  2002cited by this paper
• The hunt for nutritional and pharmacological modulators of paraoxonase.

  2002cited by this paper
• Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation.

  2002cited by this paper
• Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase

  2002cited by this paper
• Wine Flavonoids Protect against LDL Oxidation and Atherosclerosis

  2002cited by this paper
• Preservation of Paraoxonase Activity by Wine Flavonoids

  2002cited by this paper
• DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation.

  2002cited by this paper
• Enzymatically Active Paraoxonase-1 Is Located at the External Membrane of Producing Cells and Released by a High Affinity, Saturable, Desorption Mechanism*

  2002cited by this paper
• Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes*

  2002cited by this paper
• A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol.

  2001cited by this paper
• Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.

  2001cited by this paper
• 7-Ketocholesterol Is an Endogenous Modulator for the Arylhydrocarbon Receptor*

  2001cited by this paper
• Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.

  2000cited by this paper
• Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.

  1999cited by this paper
• Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.

  1999cited by this paper
• Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity.

  1999cited by this paper
• Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*

  1998cited by this paper
• Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

  1998cited by this paper
• Plasma and tissue resveratrol concentrations and pharmacological activity.

  1998cited by this paper
• Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

  1998cited by this paper
• Down-regulation of Cytochrome P450 1A1 Gene Promoter by Oxidative Stress

  1998cited by this paper
• Inhibition of human LDL oxidation by resveratrol

  1993cited by this paper
• Inhibition of human LDL oxidation by resveratrol.

  1993cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Resveratrol Acts as a Mixed Agonist/Antagonist for

  year unknowncited by this paper

• Computational discovery of novel aryl hydrocarbon receptor modulators for psoriasis therapy

  2025cites this paper
• Resveratrol Relieves Hepatic Steatosis and Enhances the Effects of Atorvastatin in a Mouse Model of NAFLD by Regulating the Renin‐Angiotensin System, Oxidative Stress, and Inflammation

  2025cites this paper
• Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases.

  2024cites this paper
• Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer’s Disease

  2024cites this paper
• Mapping the influence of hydrocarbons mixture on molecular mechanisms, involved in breast and lung neoplasms: in silico toxicogenomic data-mining

  2024cites this paper
• The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis

  2024cites this paper
• The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process

  2023cites this paper
• Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases

  2022cites this paper
• Comparison of DNA methylation measurements from EPIC BeadChip and SeqCap targeted bisulphite sequencing in PON1 and nine additional candidate genes

  2022cites this paper
• Applications of resveratrol in the treatment of gastrointestinal cancer.

  2022cites this paper
• Tackling Atherosclerosis via Selected Nutrition

  2022cites this paper
• Novel cytotoxic amphiphilic nitro-compounds derived from a synthetic route for paraconic acids

  2021cites this paper
• Aggressiveness and Metastatic Potential of Breast Cancer Cells Co-Cultured with Preadipocytes and Exposed to an Environmental Pollutant Dioxin: An in Vitro and in Vivo Zebrafish Study

  2021cites this paper
• Oxidative Stress, Plant Natural Antioxidants, and Obesity

  2021cites this paper
• Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence

  2021cites this paper
• مطالعهی فعالیت آنتی اکسیدانی عصارهی هیدروالکلی گیاه Thymus Kotschyanus و تأثیر آن بر فعالیت آنزیم پاراکسوناز 1 سرمی افراد سالم و دیابتی در شرایط آزمایشگاهی

  2021cites this paper
• The effect of resveratrol supplementation on serum levels of asymmetric de-methyl-arginine and paraoxonase 1 activity in patients with type 2 diabetes: A randomized, double-blind controlled trial.

  2020cites this paper
• Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

  2020cites this paper
• Paraoxonase (PON1), detoxification of nerve agents, and modulation of their toxicity

  2020cites this paper
• The Effects of Anthocyanins and Their Microbial Metabolites on the Expression and Enzyme Activities of Paraoxonase 1, an Important Marker of HDL Function

  2019cites this paper
• Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells

  2017cites this paper
• Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.

  2017cites this paper
• The role of paraoxonase in cancer.

  2017cites this paper
• Role of polyphenols and polyphenol-rich foods in the modulation of PON1 activity and expression.

  2017cites this paper
• Phenolic compounds increase the transcription of mouse intestinal maltase-glucoamylase and sucrase-isomaltase.

  2017cites this paper
• The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation

  2017cites this paper
• Resveratrol fails to provide prophylactic protection in a rat model of organophosphate poisoning

  2016cites this paper
• Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach.

  2016cites this paper
• Antioxidant Functions of the Aryl Hydrocarbon Receptor

  2016cites this paper
• PON1 and Mediterranean Diet

  2015cites this paper
• Paraoxonase (PON1) and Detoxication of Nerve Agents

  2015cites this paper
• Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes.

  2014cites this paper
• Revealed by Site-Directed Mutagenesis Receptor Agonists and Antagonists Ligand Promiscuity of Aryl Hydrocarbon

  2014cites this paper
• The effect of sumac (Rhus coriaria L.) powder on insulin resistance, malondialdehyde, high sensitive C-reactive protein and paraoxonase 1 activity in type 2 diabetic patients

  2014cites this paper
• Paraoxonases function as unique protectors against cardiovascular diseases and diabetes: Updated experimental and clinical data

  2014cites this paper
• Resveratrol and cardiovascular health--promising therapeutic or hopeless illusion?

  2014cites this paper
• Resveratrol—The “Chateau Hormone” for Cardio Diabetic Protection

  2014cites this paper
• Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin.

  2014cites this paper
• Ligand Promiscuity of Aryl Hydrocarbon Receptor Agonists and Antagonists Revealed by Site-Directed Mutagenesis

  2014cites this paper
• Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.

  2013cites this paper
• Rôle de la Paraoxonase (PON1) dans l'activité anti-inflammatoire de HDL et sa modulation par la diète

  2013cites this paper
• Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

  2013cites this paper
• Ethanol extract of Graptopetalum paraguayense upregulates paraoxonase 1 gene expression via an AKT/NF-κB-dependent pathway.

  2012cites this paper
• Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.

  2012cites this paper
• Regulation of Hepatic Paraoxonase-1 Expression

  2012cites this paper
• Antioxidant and Anti-Inflammatory Role of Paraoxonase 1: Implication in Arteriosclerosis Diseases

  2012cites this paper
• Crossroads in the evaluation of paraoxonase 1 for protection against nerve agent and organophosphate toxicity.

  2012cites this paper
• The Relationship Between Oxidized Low-Density Lipoprotein and Paraoxonase 1 Following Acute Exercise.

  2012cites this paper
• The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

  2012cites this paper
• Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

  2012cites this paper
• Transcriptional Regulation of Human Drug‐Metabolizing Cytochrome P450 Enzymes

  2012cites this paper
• Systematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cells

  2011cites this paper
• Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome p450 enzymes.

  2011cites this paper
• Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.

  2011cites this paper
• Recombinant paraoxonase 1 protects against sarin and soman toxicity following microinstillation inhalation exposure in guinea pigs.

  2011cites this paper
• Antioxidants as Targeted Therapy: A Special Protective Role for Pomegranate and Paraoxonases (PONs)

  2011cites this paper
• Responses Of paraoxonase 1 to dioxin-like pcb 126 ( 3,3',4,4',5-pentachlorobiphenyl): mechanisms and consequences

  2011influential citation
• The three-gene paraoxonase family: physiologic roles, actions and regulation.

  2011cites this paper
• Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs.

  2011cites this paper
• Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase 1 gene transcription by berberine in human HepG2 cells.

  2011cites this paper
• Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art.

  2011cites this paper
• Determinants of paraoxonase 1 status: genes, drugs and nutrition.

  2011cites this paper
• Steroid regulation of drug-metabolizing cytochromes P450.

  2011cites this paper
• Diet and Paraoxonase 1 Enzymatic Activity in Diabetic Foot Patients from Romania and Belgium: Favorable Association of High Flavonoid Dietary Intake with Arylesterase Activity

  2010cites this paper
• Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo

  2010cites this paper
• Resveratrol commonly displays hormesis: Occurrence and biomedical significance

  2010cites this paper
• Paraoxonase-1 and its Interactions with HDL

  2010cites this paper
• A homogeneous cell-based assay for measurement of endogenous paraoxonase 1 activity.

  2010cites this paper
• Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway.

  2010cites this paper
• Effect of quercetin on paraoxonase 1 activity--studies in cultured cells, mice and humans.

  2010cites this paper
• Commentary on Resveratrol and Hormesis: Resveratrol—a hormetic marvel in waiting?

  2010cites this paper
• Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.

  2010cites this paper
• TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts.

  2010cites this paper
• Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates

  2010cites this paper
• Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids

  2010cites this paper
• The Effects of Resveratrol on the Healing of Left Colonic Anastomosis

  2009cites this paper
• CHAPTER 67 – Paraoxonase (PON1) and Detoxication of Nerve Agents

  2009cites this paper
• Pharmacological and lifestyle factors modulating serum paraoxonase-1 activity.

  2009cites this paper
• Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.

  2009cites this paper
• araoxonase 1 ( PON 1 ) expression in hepatocytes is upregulated by pomegranate olyphenols : A role for PPAR-pathway

  2009cites this paper
• The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver

  2009cites this paper
• Reactive oxygen species and antioxidants in the pathophysiology of cardiovascular disease: does the actual knowledge justify a clinical approach?

  2009cites this paper
• Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice.

  2009cites this paper
• Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines

  2008influential citation
• Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.

  2008cites this paper
• Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans

  2008cites this paper
• Transcriptional Regulation of the Paraoxonase Genes

  2008cites this paper
• The red wine hypothesis: from concepts to protective signalling molecules.

  2007cites this paper
• Understanding changes in high density lipoproteins during the acute phase response.

  2006cites this paper
• A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids Published, JLR Papers in Press, November 3, 2005.

  2006cites this paper
• Reciprocal and Coordinate Regulation of Serum Amyloid A Versus Apolipoprotein A-I and Paraoxonase-1 by Inflammation in Murine Hepatocytes

  2006cites this paper
• Nouvelles technologies en toxicologie de l’environnement Bases fondamentales et applications

  2006cites this paper
• Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences

  2005cites this paper