Alterations of the FHIT gene in human hepatocellular carcinoma.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Research

• Publication date

  2000-02-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10706123
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Role of FHIT in human cancer.

  1999cited by this paper
• Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines.

  1999cited by this paper
• Different gene expression of MDM2, GAGE-1, Ð2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia

  1999cited by this paper
• Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization

  1999cited by this paper
• The role of the FHIT/FRA3B locus in cancer.

  1998cited by this paper
• FHITness and cancer.

  1998cited by this paper
• An FHIT tumor suppressor gene?

  1998cited by this paper
• Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos.

  1998cited by this paper
• Aberrant FHIT transcripts in hepatocellular carcinomas.

  1998cited by this paper
• Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas.

  1998cited by this paper
• Clonal genetic alterations in the lungs of current and former smokers.

  1997cited by this paper
• Semiautomated resolution of overlapping stutter patterns in genomic microsatellite analysis.

  1997influential reference
• Molecular damage in the bronchial epithelium of current and former smokers.

  1997cited by this paper
• Replacement of Fhit in cancer cells suppresses tumorigenicity.

  1997cited by this paper
• Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.

  1997influential reference
• Association between cigarette smoking and FHIT gene alterations in lung cancer.

  1997influential reference
• Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

  1997cited by this paper
• A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

  1997cited by this paper
• FHIT gene alterations in head and neck squamous cell carcinomas.

  1996cited by this paper
• The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

  1996cited by this paper
• FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.

  1996cited by this paper
• Chromosome fragility and instability in human cancer.

  1994cited by this paper
• Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma

  1991cited by this paper
• Hepatocellular carcinogenesis: recent advances and speculations.

  1990cited by this paper
• Hepatocellular carcinogenesis: recent advances and speculations.

  1990cited by this paper
• Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas.

  1988cited by this paper
• Fragile sites are targets of diverse mutagens and carcinogens.

  1987cited by this paper
• Fragile sites are targets of diverse mutagens and carcinogens.

  1987cited by this paper
• The most common fragile site in man is 3p14

  1986cited by this paper

• Effects of trichostatin A on FHIT and WWOX genes expression, cell growth inhibition and apoptosis induction in hepatocellular carcinoma WCH 17 cell line

  2021cites this paper
• Association of FHIT expression and FHIT gene hypermethylation with liver cancer risk: a PRISMA-compliant meta-analysis

  2017cites this paper
• Expression and Prognostic Role of FHIT, Fibronectin, and PTEN in Hepatocellular Carcinoma.

  2016cites this paper
• Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.

  2012cites this paper
• HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells.

  2012cites this paper
• Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: Potential prospects for combined targeted therapeutics

  2012cites this paper
• Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.

  2011cites this paper
• FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1.

  2011cites this paper
• Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.

  2009cites this paper
• The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.

  2008cites this paper
• Tumor suppressor and hepatocellular carcinoma.

  2008cites this paper
• Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells.

  2008cites this paper
• Specific 5′CpG Island Methylation Signatures of FHIT and p16 Genes and Their Potential Diagnostic Relevance in Indian Breast Cancer Patients

  2008cites this paper
• Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea.

  2008cites this paper
• Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma

  2008cites this paper
• Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis.

  2007cites this paper
• Gain of Chromosome 8q: A Potential Prognostic Marker in Resectable Adenocarcinoma of the Pancreas?

  2007cites this paper
• The transmembrane protein TMEM7 is an IFN- α responsive gene that suppresses cell proliferation and is down-regulated in human hepatocellular carcinoma

  2007cites this paper
• The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma.

  2007cites this paper
• Genomic mechanisms and measurement of structural and numerical instability in cancer cells.

  2007cites this paper
• The interferon-α responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma

  2007cites this paper
• Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.

  2006cites this paper
• Tracking down gene intefrity within fragile sites: Do they play a role in oesoplageal cancer?

  2006cites this paper
• Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells.

  2006cites this paper
• Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors

  2005cites this paper
• Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.

  2005cites this paper
• Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.

  2005cites this paper
• Alterations of the fragile histidine triad gene in hepatitis C virus‐associated hepatocellular carcinoma

  2005cites this paper
• Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

  2004cites this paper
• Reduced Fhit protein expression in human malignant mesothelioma

  2004cites this paper
• Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2'-deoxycytidine.

  2004cites this paper
• Parkin gene alterations in hepatocellular carcinoma

  2004cites this paper
• FHIT mRNA and protein expression in hepatocellular carcinoma

  2004cites this paper
• SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma.

  2003cites this paper
• Genetic alterations in cancer as a result of breakage at fragile sites.

  2003cites this paper
• Loss of fragile histidine triad protein in human hepatocellular carcinoma.

  2003cites this paper
• Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53

  2003cites this paper
• Alterations in the Fhit gene in pancreatic duct adenocarcinomas induced by N‐nitrosobis(2‐oxopropyl)amine in hamsters

  2003cites this paper
• Fhit gene alterations in hepatocarcinogenesis induced by a choline‐deficient L‐amino acid–defined diet in rats

  2003cites this paper
• Expression pattern of lung cancer related genes in malignant transformation of BEP2D

  2002cites this paper
• Loss of heterozygosity and tumour suppressor gene alterations in human cancer : studies on FHIT and NF 2 genes in lung cancer , malignant mesothelioma and gastrointestinal stromal tumours

  2002cites this paper
• A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting.

  2002cites this paper
• Molecular Genetic Alterations in Primary Hepatocellular Neoplasms

  2002cites this paper
• Alterations of the Fhit gene in hepatocellular carcinomas induced by N‐nitrosodiethylamine in rats

  2002cites this paper
• Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.

  2002cites this paper
• Reciprocal translocations in breast tumor cell lines: Cloning of a t(3;20) that targets the FHIT gene

  2002cites this paper
• Genome-wide analyses on loss of heterozygosity in hepatocellular carcinoma in Southern China.

  2001cites this paper
• Comprehensive genetic analysis of cancer cells

  2000cites this paper
• Potential roles of tumor suppressor genes and microsatellite instability in hepatocellular carcinogenesis in southern African blacks.

  2000cites this paper
• Gastrointestinal Oncology

  1998cites this paper