Role of regulatory T-cells during hepatitis C infection: From the acute phase to post-transplantation recurrence.

Hepatitis C viral infection persists and becomes chronic in a majority of affected individuals. Numerous factors have been described to explain how the virus manages to escape the host immune system. One important escape mechanism is the increase in regulatory T cells induced by the virus. In this review, we will focus on the status of regulatory T cells throughout the natural history of hepatitis C infection and after liver transplantation. The molecular mechanisms involved in increasing the number of regulatory T cells are also discussed, as are data regarding the impact of regulatory T-cells on hepatic fibrosis in the context of hepatitis C viral infection.

• Publication year

  2015

• Venue

  Digestive and Liver Disease

• Publication date

  2015-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.dld.2015.06.014PMID 26216068
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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