Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Scandinavian Journal of Immunology

• Publication date

  1995-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1365-3083.1995.tb03550.xPMID 7532318
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Biological properties of interleukin 10].

  1994cited by this paper
• High levels of circulating IL‐10 in human malaria

  1994cited by this paper
• Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse.

  1994cited by this paper
• Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

  1994cited by this paper
• Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

  1994cited by this paper
• Optic neuritis is associated with myelin basic protein and proteolipid protein reactive cells producing interferon-gamma, interleukin-4 and transforming growth factor-beta.

  1994cited by this paper
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  1994cited by this paper
• Increased levels of interferon‐gamma (IFN‐γ), IL‐4 and transforming growth factor‐beta (TGF‐β) mRNA expressing blood mononuclear cells in human HIV infection

  1994cited by this paper
• Optic neuritis is associated with myelin basic protein and proteolipid protein reactive cells producing interferon-γ, interleukin-4 and transforming growth factor-β

  1994cited by this paper
• Optic neuritis and multiple sclerosis

  1993cited by this paper
• Potential role for interleukin-10 in the immunosuppression associated with kala azar.

  1993cited by this paper
• Interleukin-10.

  1993cited by this paper
• Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10.

  1993cited by this paper
• T Cells Recognizing Multiple Peptides of Myelin Basic Protein are Found in Blood and Enriched in Cerebrospinal Fluid in Optic Neuritis and Multiple Sclerosis

  1993cited by this paper
• Biological properties of interleukin 10.

  1992cited by this paper
• Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

  1992cited by this paper
• Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

  1992cited by this paper
• Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.

  1992cited by this paper
• Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

  1992cited by this paper
• Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection

  1992cited by this paper
• Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

  1991cited by this paper
• Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

  1991cited by this paper
• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

  1991cited by this paper
• Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

  1991cited by this paper
• IL-10 inhibits cytokine production by activated macrophages.

  1991cited by this paper
• Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells

  1991cited by this paper
• Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

  1991cited by this paper
• IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

  1991cited by this paper
• Multiple sclerosis: a pivotal role for the T cell in lesion development

  1991cited by this paper
• An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis

  1990cited by this paper
• Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.

  1990cited by this paper
• Autoreactive T Lymphocytes inMultiple Sclerosis Determined byAntigen-induced Secretion ofInterferon-v

  1990cited by this paper
• Memory CD4+ T cells in man form two distinct subpopulations, defined by their expression of isoforms of the leucocyte common antigen, CD45.

  1990cited by this paper
• Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

  1990cited by this paper
• Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

  1989cited by this paper
• Multiple sclerosis: Involvement of interferons in lesion pathogenesis

  1988cited by this paper
• Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

  1988cited by this paper
• Origin of the autoreactive anti-type II collagen response. I. Frequency of specific and multispecific B cells in primed murine lymph nodes.

  1987cited by this paper
• T cell subsets in multiple sclerosis. Gradients at plaque borders and differences in nonplaque regions.

  1987cited by this paper
• Advances in CSF protein research and diagnosis

  1987cited by this paper
• Treatment of multiple sclerosis with gamma interferon

  1987cited by this paper
• Improved detection of oligoclonal IgG in cerebrospinal fluid by isoelectric focusing in agarose, double-antibody peroxidase labeling, and avidin-biotin amplification.

  1984cited by this paper
• Rating neurologic impairment in multiple sclerosis

  1983cited by this paper
• [Immunology of multiple sclerosis].

  1982cited by this paper
• Production and assay of antibodies to acetylcholine receptors.

  1981cited by this paper
• Two subsets of rat T lymphocytes defined with monoclonal antibodies

  1980cited by this paper
• Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid.

  1977cited by this paper
• Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.

  1972cited by this paper
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  1965cited by this paper

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  2025cites this paper
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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis

  2012cites this paper
• Influence of histocompatibility genes on disease susceptibility and treatment response in patients with relapsing-remitting multiple sclerosis treated with interferon β-1a

  2011cites this paper
• Effect of exercise therapy on muscle contractile properties in experimental autoimmune encephalomyelitis and multiple sclerosis

  2011cites this paper
• Disease protection and interleukin‐10 induction by endogenous interferon‐β in multiple sclerosis?

  2011cites this paper
• T-cells in multiple sclerosis.

  2010cites this paper
• Immunomodulatory effects of hepatocyte growth factor in experimental autoimmune encephalomyelitis

  2010cites this paper
• Cytokines in Idiopathic Intracranial Hypertension CSF

  2010cites this paper
• IL-10-differentiated dendritic cells treatment for Experimental Autoimmune Encephalomyelitis (EAE), a model of human Multiple Sclerosis

  2010cites this paper
• IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis

  2008cites this paper
• The persistency of high levels of pSTAT3 expression in circulating CD4+ T cells from CIS patients favors the early conversion to clinically defined multiple sclerosis.

  2008cites this paper
• B-cell function in CNS inflammatory demyelinating disease: a complexity of roles and a wealth of possibilities

  2007cites this paper
• Abnormal Tr1 differentiation in multiple sclerosis.

  2007cites this paper
• Differential regulation of cytokine secretion in multiple sclerosis

  2007cites this paper
• Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway

  2005cites this paper
• Immunology of multiple sclerosis.

  2005cites this paper
• Generation and Regulation of Human Th1-Biased Immune Responses In Vivo: A Critical Role for IL-4 and IL-10 1

  2004cites this paper
• The immunomodulatory properties of in vitro immunoglobulins are dose‐dependent

  2003cites this paper
• Estudio inmunológico en la esclerosis múltiple familiar citocinas, moléculas de adhesión y receptores de quimiocinas

  2003cites this paper
• In-situ detection of both inflammatory and anti-inflammatory cytokines in resting peripheral blood mononuclear cells during pregnancy.

  2003cites this paper
• Anti-Inflammatory Cytokines: Expression and Action in the Brain

  2002cites this paper
• Cytokines in multiple sclerosis: methodological aspects and pathogenic implications

  2002cites this paper
• Cellular localization and expression patterns of interleukin‐10, interleukin‐4, and their receptors in multiple sclerosis lesions

  2002cites this paper
• Clues to the immunopathogenesis of multiple sclerosis by investigating untreated patients during the very early stage of disease

  2001cites this paper
• Interleukin-10 and the interleukin-10 receptor.

  2001cites this paper
• Matrix-degrading metalloproteinases and cytokines in multiple sclerosis and ischemic stroke

  2001cites this paper
• Randomized study of antibodies to IFN-g and TNF-a in secondary progressive multiple sclerosis

  2001cites this paper
• Immunological markers in multiple sclerosis

  2000cites this paper
• Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS.

  2000cites this paper
• Multiple sclerosis is associated with an imbalance between tumour necrosis factor‐alpha (TNF‐α)‐ and IL‐10‐secreting blood cells that is corrected by interferon‐beta (IFN‐β) treatment

  2000cites this paper
• Defective regulation of IFNγ and IL-12 by endogenous IL-10 in progressive MS

  2000cites this paper
• Multiple Sclerosis: Levels of Interleukin‐10‐Secreting Blood Mononuclear Cells are Low in Untreated Patients but Augmented During Interferon‐β‐1b Treatment

  1999cites this paper
• Expression of costimulatory molecules and cytokines in CSF and peripheral blood mononuclear cells from multiple sclerosis patients.

  1999cites this paper
• Interferon beta-1b treatment modulates TNFα and IFNγ spontaneous gene expression in MS

  1999cites this paper
• Partial IL-10 inhibition of the cell-mediated immune response in chronic beryllium disease.

  1999cites this paper
• Changes in plasma cytokines induced by interferon-beta1a treatment in patients with multiple sclerosis.

  1999cites this paper
• Decreased interleukin‐10 and increased interleukin‐12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis

  1999cites this paper
• Markers in the promoter region of interleukin-10 (IL-10) gene in myasthenia gravis: implications of diverse effects of IL-10 in the pathogenesis of the disease.

  1999cites this paper
• Cytokine analysis in multiple sclerosis by competitive RT - PCR: A decreased expression of IL-10 and an increased expression of TNF-α in chronic progression

  1999cites this paper
• Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines.

  1999cites this paper
• Interferon beta-1b treatment modulates TNFalpha and IFNgamma spontaneous gene expression in MS.

  1999cites this paper
• Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

  1999cites this paper
• Optic neuritis and cytokines

  1998cites this paper
• Interleukin‐12 and Perforin mRNA Expression is Augmented in Blood Mononuclear Cells in Multiple Sclerosis

  1998cites this paper
• Corticosteroids induce expression of transforming-growth-factor-beta1 mRNA in peripheral blood mononuclear cells of patients with multiple sclerosis.

  1998cites this paper
• The cytokine storm in multiple sclerosis

  1998cites this paper
• Linomide (roquinimex) affects the balance between pro‐ and anti‐inflammatory cytokines in vitro in multiple sclerosis

  1998cites this paper
• Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse.

  1998cites this paper
• Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage.

  1998cites this paper
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  1998cites this paper
• Data on cytokine mRNA expression in CSF and peripheral blood mononuclear cells from MS patients as detected by PCR

  1998cites this paper
• Elevated serum levels of IFN-γ, IL-4 and TNF-α/ unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage

  1998cites this paper
• Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis.

  1998cites this paper
• Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis

  1998cites this paper
• Cytokine mRNA expression in CSF and peripheral blood mononuclear cells in multiple sclerosis: detection by RT-PCR without in vitro stimulation.

  1997cites this paper
• Autoantigen‐induced IL‐13 mRNA expression is increased in blood mononuclear cells in myasthenia gravis and multiple sclerosis

  1997cites this paper
• Cytokine secretion and nitric oxide production by mononuclear cells of patients with multiple sclerosis.

  1997cites this paper
• Cytokines and the pathogenesis of myasthenia gravis

  1997cites this paper
• Cytokine profile in interferon‐β treated multiple sclerosis patients: reduction of interleukin‐10 mRNA expressing cells in peripheral blood

  1997cites this paper
• Cytokines and soluble IL‐4 in patients with acute optic neuritis and multiple sclerosis

  1997cites this paper
• IL-4, IL-10 and IFN-gamma have distinct, but interacting, effects on differentiation-induced changes in TNF-alpha and TNF receptor release by cultured human monocytes.

  1996cites this paper
• Review: cytokines and the pathogenesis of multiple sclerosis

  1996cites this paper
• The anterior visual pathways--Part II.

  1996cites this paper
• The pattern of production of cytokine mRNAs is markedly altered at the onset of multiple sclerosis.

  1996cites this paper
• Increased interleukin-6 mRNA expression in blood and cerebrospinal fluid mononuclear cells in multiple sclerosis.

  1996cites this paper
• Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis

  1996cites this paper
• Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis.

  1996cites this paper
• Critical Influences of the Cytokine Orchestration on the Outcome of Myelin Antigen‐Specific T‐Cell Autoimmunity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

  1995cites this paper
• Expression of IFN-gamma, IL-4, and TGF-beta in multiple sclerosis in relation to HLA-Dw2 phenotype and stage of disease.

  1995cites this paper
• Alterations in peripheral blood mononuclear cell cytokine production in response to phytohemagglutinin in multiple sclerosis patients

  1995cites this paper
• Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis

  1995cites this paper
• Expression of IFN-γ, IL-4, and TGF-β in multiple sclerosis in relation to HLA-Dw2 phenotype and stage of disease

  1995cites this paper
• Role of cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis

  1994cites this paper