Synergistic effect of 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide and titanium oxide on the redox behaviour of flunarizine in solubilized media.

Titanium oxide nanoparticles and 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide modified glassy carbon electrode (TiO2/IL/GCE) has been fabricated for electrochemical sensing of flunarizine (FRH). The electrochemical properties and morphology of the prepared nanocomposite were studied by electrochemical impedance spectroscopy (EIS) and transmission electron microscopy (TEM). The response of the electrochemical sensor was found to be proportional to the concentrations of FRH in the range from 0.5 μgmL-1 to 16 μgmL-1. The detection limit obtained was 0.03 μgmL-1. The proposed method was also applied to the determination of FRH in pharmaceutical formulation and human serum with good recoveries.

• Publication year

  2018

• Venue

  Colloids and Surfaces B: Biointerfaces

• Publication date

  2018-06-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/j.colsurfb.2018.02.057PMID 29544130
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ionic Liquids in HPLC and CE: A Hope for Future

  2017cited by this paper
• Uptake of propranolol on ionic liquid iron nanocomposite adsorbent: Kinetic, thermodynamics and mechanism of adsorption

  2017cited by this paper
• Review—New Generation Electrode Materials for Sensitive Detection

  2016cited by this paper
• (1-Butyl-3-methylimidazolium Hexafluorophosphate) Based Sensor for Quantification of Eugenol Antioxidant

  2016cited by this paper
• Electrocatalytic quantification of thrombin inhibitor dabigatran etexilate in solubilized system

  2015cited by this paper
• Highly sensitive and selective polyaniline–zinc oxide nanocomposite sensor for betahistine hydrochloride in solubilized system

  2014cited by this paper
• TiO2-Multi Walled Carbon Nanotubes Hybrid Film Sensor for Sensing of Antiprotozoal Agent Satranidazole in Solubilzed System

  2013cited by this paper
• Determination of Flunarazine Dihydrchloride in Bulk Drug and Tablets by RP-UPLC: A Stability-Indicating Assay

  2013cited by this paper
• Development and validation of a rapid chromatographic method for the analysis of flunarizine and its main production impurities

  2012cited by this paper
• Electrochemical determination of acetaminophen based on TiO2–graphene/poly(methyl red) composite film modified electrode

  2012cited by this paper
• Simultaneous Estimation of Flunarizinedihydrochloride and Propranolol hydrochloride in Bulk Drug and Capsule

  2012cited by this paper
• Q-Absorbance and Multicomponent UV Spectrophotometric Methods forSimultaneous Estimation of Propranolol Hydrochloride and FlunarizineDihydrochloride in Capsules

  2011cited by this paper
• Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode.

  2011cited by this paper
• Voltammetric oxidation and determination of cinnarizine at glassy carbon electrode modified with multi-walled carbon nanotubes.

  2009cited by this paper
• Comparison of UV spectrophotometric method and high performance liquid chromatography for the analysis of flunarizine and its application for the dissolution test.

  2006cited by this paper
• Beneficial role of surfactants in electrochemistry and in the modification of electrodes.

  2006cited by this paper
• SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF CINNARIZINE AND FLUNARIZINE DIHYDROCHLORIDE IN PURE AND DOSAGE FROMS.

  2004cited by this paper
• HPLC Determination of Flunarizine Dihydrochloride in Tablets and Its Validation

  2003cited by this paper
• Pharmacological involvement of the calcium channel blocker flunarizine in dopamine transmission at the striatum.

  2001cited by this paper
• Determination of flunarizine in rat brain by liquid chromatography-electrospray mass spectrometry.

  1999cited by this paper
• The study of the voltammetric behaviour of flunarizine.

  1999cited by this paper
• Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II).

  1999cited by this paper
• Liquid chromatographic determination of flunarizine dihydrochloride in the presence of its degradation product.

  1995cited by this paper
• Spectrophotometric determination of flunarizine dihydrochloride through the formation of charge-transfer complex with iodine.

  1995cited by this paper
• Electrochemical Methods: Fundamentals and Applications

  1980cited by this paper
• General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems

  1979cited by this paper

• Voltammetric Determination of Ferulic Acid on Carbon Mesoporous Modified Glassy Carbon Electrode

  2023cites this paper
• Electrochemical Determination of Chlorogenic Acid in Nutraceuticals Using Voltammetric Sensors Based on Screen-Printed Carbon Electrode Modified with Graphene and Gold Nanoparticles

  2021cites this paper
• The efficacy of flunarizine combined with nimodipine in patients with subarachnoid hemorrhage-induced cerebral vasospasms and the combination’s effects on the vascular endothelial functions and the inflammatory factors

  2020cites this paper
• Nanogold modified glassy carbon sensor for the quantification of phytoestrogenchlorogenic acid

  2020cites this paper
• A Review: New Trends in Electrode Systems for Sensitive Drug and Biomolecule Analysis

  2020cites this paper
• Application of micellar catalysis in ultrasensitive quantification of drotaverine hydrochloride

  2019cites this paper
• TiO2/(1-butyl-3-methylimidazolium hexafluorophosphate) Based Sensor: A Strategy for the Detection of Cinnamaldehyde

  2019cites this paper