Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Structural Biology

• Publication date

  2016-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jsb.2016.06.002PMID 27268273
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

  2016cited by this paper
• Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily

  2015cited by this paper
• The PDB_REDO server for macromolecular structure model optimization

  2014cited by this paper
• SnapShot: Bioactive lysophospholipids.

  2012cited by this paper
• Presenting your structures: the CCP4mg molecular-graphics software

  2011cited by this paper
• Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

  2011cited by this paper
• Biological phosphoryl-transfer reactions: understanding mechanism and catalysis.

  2011cited by this paper
• iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

  2011cited by this paper
• X-Ray Structure Reveals a New Class and Provides Insight into Evolution of Alkaline Phosphatases

  2011cited by this paper
• Insights into autotaxin: how to produce and present a lipid mediator

  2011cited by this paper
• Structural basis for substrate discrimination and integrin binding by autotaxin

  2010cited by this paper
• Crystallization and preliminary X-ray diffraction analysis of rat autotaxin.

  2010cited by this paper
• Theoretical study of phosphodiester hydrolysis in nucleotide pyrophosphatase/phosphodiesterase. Environmental effects on the reaction mechanism.

  2010cited by this paper
• Lysophosphatidic acid (LPA) and its receptors.

  2009cited by this paper
• IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

  2009cited by this paper
• RAPIDO: a web server for the alignment of protein structures in the presence of conformational changes

  2008cited by this paper
• MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

  2007cited by this paper
• PDB Improvement Starts with Data Deposition

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine

  2006cited by this paper
• Alkaline phosphatase, solution structure, and mechanism.

  2006cited by this paper
• Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: implications for mechanism and evolution.

  2006cited by this paper
• Scaling and assessment of data quality.

  2006cited by this paper
• NPP-type ectophosphodiesterases: unity in diversity.

  2005cited by this paper
• Phosphate binding in the active site of alkaline phosphatase and the interactions of 2-nitrosoacetophenone with alkaline phosphatase-induced small structural changes.

  2004cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes

  2004cited by this paper
• REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use.

  2004cited by this paper
• The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds.

  2004cited by this paper
• Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

  2002cited by this paper
• Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase*

  2002cited by this paper
• Evidence for direct attack by hydroxide in phosphodiester hydrolysis.

  2002cited by this paper
• Structural and Catalytic Similarities between Nucleotide Pyrophosphatases/Phosphodiesterases and Alkaline Phosphatases*

  2001cited by this paper
• A Model of the Transition State in the Alkaline Phosphatase Reaction*

  1999cited by this paper
• A superfamily of metalloenzymes unifies phosphopentomutase and cofactor‐independent phosphoglycerate mutase with alkaline phosphatases and sulfatases

  1998cited by this paper
• Refinement of macromolecular structures by the maximum-likelihood method.

  1997cited by this paper
• Trapping and visualization of a covalent enzyme–phosphate intermediate

  1997cited by this paper
• Mechanisms of phosphoryl and acyl transfer

  1995cited by this paper
• Structure and mechanism of alkaline phosphatase.

  1992cited by this paper
• Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.

  1992cited by this paper
• Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.

  1991cited by this paper
• Structural Biology and Crystallization Communications Mammalian Cell Expression, Purification, Crystallization and Microcrystal Data Collection of Autotaxin/enpp2, a Secreted Mammalian Glycoprotein

  year unknowncited by this paper

• DSSP 4: FAIR annotation of protein secondary structure

  2025cites this paper
• An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

  2025cites this paper
• Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling

  2023influential citation
• Interaction of Vanadium Complexes with Proteins: Revisiting the Reported Structures in the Protein Data Bank (PDB) since 2015

  2023cites this paper
• Mechanistic and evolutionary insights into alkaline phosphatase superfamily through structure-function studies on Sphingomonas alkaline phosphatase.

  2023cites this paper
• Linking medicinal cannabis to autotaxin- 1 lysophosphatic acid signaling 2

  2022cites this paper
• Linking medicinal cannabis to autotaxin-lysophosphatic acid signaling

  2022cites this paper
• Linking medicinal cannabis to autotaxin- 1 lysophosphatic acid signaling 2

  2022cites this paper
• Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores.

  2021cites this paper
• Boron and covalent inhibition

  2021cites this paper
• Druggable Lysophospholipid Signaling Pathways.

  2020cites this paper
• Discovery of Novel Indole-based Allosteric Highly Potent ATX Inhibitors with Great in vivo Efficacy in Mouse Lung Fibrosis Model.

  2020cites this paper
• Druggable Lipid Signaling Pathways

  2020cites this paper
• OTT_A_223946 10597..10613

  2019cites this paper
• Nucleic Acid Aptamer: A Novel Potential Diagnostic and Therapeutic Tool for Leukemia

  2019cites this paper
• The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions

  2019cites this paper
• Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors.

  2019cites this paper
• Structural basis for nucleotide recognition by the ectoenzyme CD203c

  2018cites this paper
• Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3)

  2018cites this paper
• Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain.

  2018cites this paper
• Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

  2018cites this paper
• Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency

  2018cites this paper