Structure of the cobalamin-binding protein of a putative O-demethylase from Desulfitobacterium hafniense DCB-2

H. Sjuts,M. Dunstan,K. Fisher,D. Leys

Published 2013 in Acta Crystallographica Section D: Biological Crystallography

ABSTRACT

The first crystal structure of the vitamin B12-binding protein from a three-component O-demethylase enzyme system is reported. During O-demethylation methyl groups are transferred from phenyl methyl ethers to tetrahydrofolate via methyl-B12 intermediates.

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