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Different body mass index grade on the risk of developing glioma: a meta-analysis

Zi-Feng Dai,Qi-lin Huang,Hai-peng Liu

Published 2015 in Chinese Neurosurgical Journal

ABSTRACT

BackgroundPrevious studies reported conflicting results about the risk of developing glioma and different body mass index. So we decided to execute a meta-analysis to solve the dispute.MethodsComprehensive literature retrieval was carried in PubMed, MEDLINE, and EMBASE up to September 15, 2014. Hand literature information retrieval was not carried. Six studies were fit for this meta-analysis. Pooled hazard ratio (HR) and 95 % confidence interval (CI) of different body mass index grade were performed by fixed/random-effects models, except for normal weight which was referent.ResultsData of 3726 cases were included. Compared with normal weight (20 kg.m−2 < body mass index (BMI) ≤ 24.9 kg.m−2), the underweight (BMI ≤ 20 kg.m−2) might have lower incidence on the risk of developing glioma (HR = 1.08, 95 % CI ranged 0.74 to 1.58, P = 0.678). While the overweight (25 kg.m−2 < BMI ≤ 29.9 kg.m−2) and obesity (BMI ≥ 30 kg.m−2) were performed as a risk factor of developing glioma. The pooled HR of overweight group was 1.12 (95 % CI ranged 1.02 to 1.22, P = 0.013); the pooled HR of obesity was 1.14 (95 % CI ranged 1.02 to 1.27, P = 0.017). Sensitivity analysis approved that our results were stable. There was no publication bias of these studies.ConclusionsUnderweight could decrease the risk of developing glioma. Excess BMI was considered as a risk factor to develop glioma.

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