Trans-3′-hydroxycotinine as a main metabolite in urine of smokers

No abstract is available for this paper.

• Publication year

  1987

• Venue

  International Archives of Occupational and Environmental Health

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00378497PMID 3557628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gas chromatographic determination of trans-3'-hydroxycotinine, a major metabolite of nicotine in smokers.

  1987cited by this paper
• High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.

  1984cited by this paper
• Simultaneous determination of nicotine and cotinine in human plasma by nitrogen detection gas-liquid chromatography.

  1981cited by this paper
• The tautomeric structures of 5-hydroxycotinine, a secondary mammalian metabolite of nicotine

  1981cited by this paper
• Rapid gas-liquid chromatographic determination of cotinine in biological fluids.

  1980cited by this paper
• Improved gas‐chromatographic method and micro‐extraction technique for the measurement of nicotine in biological fluids

  1979cited by this paper
• Structure of hydroxycotinine, a nicotine metabolite.

  1972cited by this paper
• The analysis of nicotine‐1‘‐N‐oxide in urine, in the presence of nicotine and cotinine, and its application to the study of in vivo nicotine metabolism in man

  1971cited by this paper
• The Synthesis of Hydroxycotinine and Studies on Its Structure1

  1963cited by this paper
• Studies on the metabolism of (-)-cotinine in the human.

  1962cited by this paper

• Difference in nicotine metabolism as a potential factor causing disparities in tobacco consumption estimates by wastewater-based epidemiology

  2025cites this paper
• The Associations of Trans-3′-Hydroxy Cotinine, Cotinine, and the Nicotine Metabolite Ratio in Pediatric Patients with Tobacco Smoke Exposure

  2023cites this paper
• Comprehensive metabolic study of nicotine in equine plasma and urine using liquid chromatography/high-resolution mass spectrometry for the identification of unique biomarkers for doping control.

  2022cites this paper
• Biochemistry of nicotine metabolism and its relevance to lung cancer

  2021cites this paper
• A review of the analysis of biomarkers of exposure to tobacco and vaping products.

  2020cites this paper
• Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

  2020cites this paper
• A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine

  2018influential citation
• LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine

  2018cites this paper
• LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine

  2018cites this paper
• Investigation of Toxicity of Cigarette Butts Collected in Addis Ababa to Swiss Albino Mice

  2016cites this paper
• Menthol Attenuates Respiratory Irritation and Elevates Blood Cotinine in Cigarette Smoke Exposed Mice

  2015cites this paper
• Biomonitoring and Biomarkers

  2015cites this paper
• The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys

  2014cites this paper
• Fetal and Neonatal Exposure to Nicotine Augments Hepatic Fatty Acid Synthesis in Rat Offspring Long-Term

  2013cites this paper
• The Effect of Menthol on Nicotine Metabolism: a Cross Species Evaluation

  2013cites this paper
• Measurement of nicotine, cotinine and trans-3'-hydroxycotinine in meconium by liquid chromatography-tandem mass spectrometry.

  2011cites this paper
• Nicotine chemistry, metabolism, kinetics and biomarkers.

  2009cites this paper
• Untersuchung der Nikotinkinetik in Abhängigkeit von biologischen und rauchanamnestischen Variablen

  2008cites this paper
• [Pharmacotherapy of smoking cessation with application of nicotine and nicotine free drugs].

  2008cites this paper
• Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.

  2007cites this paper
• Relationship between machine-derived smoke yields and biomarkers in cigarette smokers in Germany.

  2007cites this paper
• Evaluation of urinary trans-3′-hydroxycotinine as a biomarker of children's environmental tobacco smoke exposure

  2006cites this paper
• Usefulness of salivary trans-3'-hydroxycotinine concentration and trans-3'-hydroxycotinine/cotinine ratio as biomarkers of cigarette smoke in pregnant women.

  2005cites this paper
• Metabolism and Disposition Kinetics of Nicotine

  2005cites this paper
• The pharmacokinetics of cotinine in plasma and saliva from non-smoking healthy volunteers

  2004cites this paper
• Cotinine determination by immunoassays may be influenced by other nicotine metabolites

  2004cites this paper
• Occupational exposure of non-smoking restaurant personnel to environmental tobacco smoke in Finland.

  2003cites this paper
• Tobacco or Health?

  2002cites this paper
• High-performance liquid chromatographic assay for N-glucuronidation of nicotine and cotinine in human liver microsomes.

  2002cites this paper
• smokeless tobacco, switching to products with greater nicotine delivery may also contribute to nicotine dose escalation (US DHHS

  2001cites this paper
• Assessment of prenatal smoke exposure by determining nicotine and its metabolites in maternal and neonatal urine

  2001cites this paper
• Trans-3'-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking.

  2001cites this paper
• ANALYTICAL IMPROVEMENTS IN BARLOW REACTION COUPLED TO HPLC DETECTION OF NICOTINE AND ITS METABOLITES

  2000cites this paper
• Pharmacotherapy of nicotine dependence.

  2000cites this paper
• A new gas chromatography-mass spectrometry method for simultaneous determination of total and free trans-3'-hydroxycotinine and cotinine in the urine of subjects receiving transdermal nicotine.

  1999cites this paper
• Analysis of nicotine, 3-hydroxycotinine, cotinine, and caffeine in urine of passive smokers by HPLC-tandem mass spectrometry.

  1999cites this paper
• The effect of ascorbic acid supplementation on the nicotine metabolism of smokers.

  1999cites this paper
• Chapter 14 – Determination of nicotine and its metabolites in biological fluids: in vivo studies

  1999cites this paper
• Characterization of multiple products of cytochrome P450 2A6-catalyzed cotinine metabolism.

  1999cites this paper
• Chapter 8 – Use of immunoassay techniques for the determination of nicotine and its metabolites

  1999cites this paper
• Chapter 3 – Biotransformation of nicotine in mammalian systems

  1999cites this paper
• Rapid and sensitive high-performance liquid chromatographic determination of nicotine and cotinine in nonsmoker human and rat urines.

  1998cites this paper
• Clinical pharmacology of nicotine.

  1998cites this paper
• Urinary cotinine as a tobacco-smoke exposure index: a minireview

  1998cites this paper
• The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers.

  1997cites this paper
• Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking.

  1997cites this paper
• Cotinine effects on nicotine metabolism

  1997cites this paper
• Biocatalysts in detoxication of drugs of abuse.

  1997cites this paper
• Immunopharmacology of inflammatory bowel disease : effects of glucocorticoids and nicotine on cytokine production

  1997cites this paper
• Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes.

  1996cites this paper
• Excretion of mutagens, nicotine and its metabolites in urine of cigarette smokers.

  1996cites this paper
• Study of Eighteen Non-Smokers Occasionally or Chronically Exposed to Environmental Tobacco Smoke

  1995cites this paper
• In vitro-in vivo correlations of human (S)-nicotine metabolism.

  1995cites this paper
• Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans.

  1995cites this paper
• Comparison of measured and FTC-predicted nicotine uptake in smokers

  1995cites this paper
• Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry.

  1994cites this paper
• Aspects of the oxidative metabolism of nicotine

  1994cites this paper
• Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine.

  1994cites this paper
• Cardiovascular effects of nicotine: relation to deleterious effects of cigarette smoking.

  1994cites this paper
• N-Oxidation, N-methylation and N-conjugation reactions of nicotine

  1993cites this paper
• Nicotine metabolism beyond cotinine

  1993cites this paper
• Variables affecting nicotine metabolism.

  1993cites this paper
• The metabolic fate of the minor tobacco alkaloids

  1993cites this paper
• Nicotine and Related Alkaloids

  1993influential citation
• Nicotine and metabolites: analysis and levels in body fluids

  1993cites this paper
• Pharmacokinetics of (S)-nicotine and metabolites in humans

  1993cites this paper
• Stereoselective metabolism of (S)-(-)-nicotine in humans: formation of trans-(S)-(-)-nicotine N-1'-oxide.

  1993cites this paper
• Gas chromatographic-mass spectrometric method for determination of anabasine, anatabine and other tobacco alkaloids in urine of smokers and smokeless tobacco users.

  1993cites this paper
• Determination of the nicotine metabolite trans-3'-hydroxycotinine in urine of smokers using gas chromatography with nitrogen-selective detection or selected ion monitoring.

  1992cites this paper
• Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3'-hydroxycotinine in smokers.

  1992cites this paper
• Characterization of the glucuronide conjugate of cotinine: a previously unidentified major metabolite of nicotine in smokers' urine.

  1992cites this paper
• Simultaneous determination of cotinine and trans-3'-hydroxycotinine in human serum by high-performance liquid chromatography.

  1992cites this paper
• [Markers for smoking].

  1992cites this paper
• Synthesis of a hapten to be used in development of immunoassays for trans-3'-hydroxycotinine, a major metabolite of cotinine.

  1991cites this paper
• Detection of Nornicotine in Human Urine after Infusion of Nicotine

  1991cites this paper
• Metabolism of nicotine.

  1991cites this paper
• Nicotine metabolism in humans

  1991cites this paper
• Effects of smoking on caffeine urinary metabolites

  1991cites this paper
• High-performance liquid-chromatographic method compared with a modified radioimmunoassay of cotinine in plasma.

  1991cites this paper
• Nicotine metabolism in stumptailed macaques, Macaca arctoides.

  1991cites this paper
• Reply

  1991cites this paper
• Nicotine metabolites in the urine of smokers.

  1990cites this paper
• Synthesis of (3'R,5'S)-trans-3'-hydroxycotinine, a major metabolite of nicotine. Metabolic formation of 3'-hydroxycotinine in humans is highly stereoselective.

  1990cites this paper
• Metabolism of nicotine by hepatocytes.

  1990cites this paper
• A convenient synthesis of trans-3'-hydroxycotinine, a major nicotine metabolite found in the urine of tobacco users.

  1990cites this paper
• Disposition of nicotine and eight metabolites in smokers and nonsmokers: Identification in smokers of two metabolites that are longer lived than cotinine

  1990cites this paper
• Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite.

  1990cites this paper
• ~ETA~~LIS~ OF NICOTINE BY HEPATOCYTES

  1990cites this paper
• Determination of nornicotine in smokers' urine by gas chromatography following reductive alkylation to N'-propylnornicotine.

  1990cites this paper
• A new quantitative thermospray LC-MS method for nicotine and its metabolites in biological fluids.

  1990cites this paper
• Exposure to Environmental Tobacco Smoke and Urinary Excretion of Cotinine and Nicotine in Children

  1989cites this paper
• Physical, Chemical, and Biologic Properties of Tobacco, Cigarette Smoke, and Other Tobacco Products

  1989cites this paper
• Capillary gas chromatographic determination of trans-3'-hydroxycotinine simultaneously with nicotine and cotinine in urine and blood samples.

  1989cites this paper
• Pharmacokinetics of nicotine, cotinine, and 3'-hydroxycotinine in cigarette smokers.

  1988cites this paper
• Trans-3'-hydroxycotinine--a main metabolite in smokers.

  1988cites this paper
• Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addiction.

  1988cites this paper
• Assessment of exposure to environmental tobacco smoke using a high-performance liquid chromatographic method for the simultaneous determination of nicotine and two of its metabolites in urine.

  1988cites this paper
• Eightfold induction of nicotine elimination in perfused rat liver by pretreatment with phenobarbital.

  1987cites this paper
• Clinical pharmacology of nicotine.

  1986cites this paper
• Tobacco Smoke : Properties , Measurement Techniques and Applications

  year unknowncites this paper