Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients

L. Franssen,I. Nijhof,S. Couto,M. Levin,G. Bos,A. Broijl,S. Klein,Yan J Ren,Maria Wang,H. Koene,A. Bloem,A. Beeker,L. Faber,E. van der Spek,R. Raymakers,R. Leguit,P. Sonneveld,S. Zweegman,H. Lokhorst,T. Mutis,A. Thakurta,Xiaozhong Qian,N. V. D. van de Donk

Published 2018 in Haematologica

ABSTRACT

Multiple myeloma (MM) patients who become refractory to anti-MM drugs have a very poor prognosis. Therefore, it is important to gain insight into the mechanisms of resistance to these drugs. Immunomodulatory drugs (IMiDs) have immune-stimulatory and anti-angiogenic properties as well as direct anti-

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