Multiple myeloma (MM) patients who become refractory to anti-MM drugs have a very poor prognosis. Therefore, it is important to gain insight into the mechanisms of resistance to these drugs. Immunomodulatory drugs (IMiDs) have immune-stimulatory and anti-angiogenic properties as well as direct anti-
Cereblon loss and up-regulation of c-Myc are associated with lenalidomide resistance in multiple myeloma patients
L. Franssen,I. Nijhof,S. Couto,M. Levin,G. Bos,A. Broijl,S. Klein,Yan J Ren,Maria Wang,H. Koene,A. Bloem,A. Beeker,L. Faber,E. van der Spek,R. Raymakers,R. Leguit,P. Sonneveld,S. Zweegman,H. Lokhorst,T. Mutis,A. Thakurta,Xiaozhong Qian,N. V. D. van de Donk
Published 2018 in Haematologica
ABSTRACT
PUBLICATION RECORD
- Publication year
2018
- Venue
Haematologica
- Publication date
2018-07-31
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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