Role of interleukin‐10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury

No abstract is available for this paper.

• Publication year

  2017

• Venue

  European Journal of Pharmacology

• Publication date

  2017-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ejphar.2017.02.016PMID 28192099PMCID PMC5411859
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke

  2016cited by this paper
• Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration

  2016cited by this paper
• Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

  2016cited by this paper
• The CD4+AT2R+ T cell subpopulation improves post-infarction remodelling and restores cardiac function

  2015cited by this paper
• Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke

  2015cited by this paper
• Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage.

  2014cited by this paper
• The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.

  2014cited by this paper
• Direct Angiotensin AT2 Receptor Stimulation Using a Novel AT2 Receptor Agonist, Compound 21, Evokes Neuroprotection in Conscious Hypertensive Rats

  2014cited by this paper
• Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARγ activation.

  2014cited by this paper
• Abstract T P204: Thioredoxin Interacting Protein: A Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

  2014cited by this paper
• Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production

  2014cited by this paper
• Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

  2014cited by this paper
• Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice

  2013cited by this paper
• IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

  2013cited by this paper
• Up-regulation of the canonical Wnt-3A and Sonic hedgehog signaling underlies melanocortin-induced neurogenesis after cerebral ischemia.

  2013cited by this paper
• AT2-receptor stimulation enhances axonal plasticity after spinal cord injury by upregulating BDNF expression.

  2013cited by this paper
• Proximal Tubule Angiotensin AT2 Receptors Mediate an Anti-Inflammatory Response via Interleukin-10: Role in Renoprotection in Obese Rats

  2013cited by this paper
• Boosting Regulatory T Cells Limits Neuroinflammation in Permanent Cortical Stroke

  2013cited by this paper
• Brain and retinal microglia in health and disease: An unrecognized target of the renin–angiotensin system

  2013cited by this paper
• Anti-inflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: Hypertension blunts the response

  2013cited by this paper
• Remote ischemic preconditioning confers late protection against myocardial ischemia–reperfusion injury in mice by upregulating interleukin-10

  2012cited by this paper
• Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo

  2012cited by this paper
• Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*

  2012cited by this paper
• Vascular Protection by Angiotensin Receptor Antagonism Involves Differential VEGF Expression in Both Hemispheres after Experimental Stroke

  2011cited by this paper
• IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways.

  2011cited by this paper
• Microbore liquid chromatography with UV detection to study the in vivo passage of compound 21, a non-peptidergic AT₂ receptor agonist, to the striatum in rats.

  2011cited by this paper
• Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen–glucose depletion

  2010cited by this paper
• Biology of interleukin-10.

  2010cited by this paper
• Identification of Noncytotoxic and IL-10–Producing CD8+AT2R+ T Cell Population in Response to Ischemic Heart Injury

  2010cited by this paper
• Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

  2009cited by this paper
• Vascular Protection with Candesartan after Experimental Acute Stroke in Hypertensive Rats: A Dose-Response Study

  2008cited by this paper
• Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection

  2006cited by this paper
• The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription.

  2005cited by this paper
• Postischemic Gene Transfer of Interleukin-10 Protects Against Both Focal and Global Brain Ischemia

  2005cited by this paper
• Postischemic Intraventricular Administration of FGF-2 Expressing Adenoviral Vectors Improves Neurologic Outcome and Reduces Infarct Volume after Transient Focal Cerebral Ischemia in Rats

  2004cited by this paper
• Neuroprotective effects of estrogen and tamoxifen in vitro

  2003cited by this paper
• Interleukin-10 Prevents Glutamate-Mediated Cerebellar Granule Cell Death by Blocking Caspase-3-Like Activity

  2001cited by this paper
• Interleukin‐10 modulates neuronal threshold of vulnerability to ischaemic damage

  2000cited by this paper
• IL-10 reduces rat brain injury following focal stroke.

  1998cited by this paper
• Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

  1986cited by this paper

• Immunological Actions of the Renin Angiotensin System

  2026cites this paper
• Neuroprotective effects of candesartan in 3-nitropropionic acid-induced Huntington’s disease: modulation of angiotensin and CREB/BDNF/PGC1-α signaling

  2025cites this paper
• Modulation of Mitochondrial Dynamics by the Angiotensin System in Dopaminergic Neurons and Microglia

  2024cites this paper
• Compound 21 Attenuates Isoflurane-Induced Injury in Neonatal Rat Hippocampal Neurons and Primary Rat Neuronal Cells by Upregulating METTL3

  2024cites this paper
• Post-stroke cognitive impairment and brain hemorrhage are augmented in hypertensive mice

  2024cites this paper
• Unveiling the neuroprotective properties of isoflavones: current evidence, molecular mechanisms and future perspectives

  2024cites this paper
• Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions

  2024cites this paper
• Maternal gut-microbiota impacts the influence of intrauterine environmental stressors on the modulation of human cognitive development and behavior.

  2024cites this paper
• Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

  2023cites this paper
• The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury

  2023cites this paper
• Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury.

  2023cites this paper
• Investigating the renoprotective effect of C21 in male mice with sepsis via modulation of p-AKT/PI3K expression

  2023cites this paper
• Pathogenesis of Chronic Kidney Disease Is Closely Bound up with Alzheimer’s Disease, Especially via the Renin-Angiotensin System

  2023cites this paper
• Endothelial Cells and the Cerebral Circulation.

  2022cites this paper
• Microglial angiotensin type 2 receptors mediate sex‐specific expression of inflammatory cytokines independently of circulating estrogen

  2022cites this paper
• Conditioned Medium of Human Pluripotent Stem Cell-Derived Neural Precursor Cells Exerts Neurorestorative Effects against Ischemic Stroke Model

  2022cites this paper
• The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target

  2022cites this paper
• Cerebrospinal fluid inflammatory markers in Alzheimer's disease: influence of comorbidities.

  2021cites this paper
• Effect of EGCG on inflammatory reaction in rats suffered cerebral ischemia/reperfusion injury.

  2021cites this paper
• Angiotensin type 2 receptor activation limits kidney injury during early phase and induces Treg cells during late phase of renal ischemia.

  2021cites this paper
• Trichosanthis Semen Suppresses Lipopolysaccharide-Induced Neuroinflammation by Regulating the NF-κB Signaling Pathway and HO-1 Expression in Microglia

  2021cites this paper
• Crosstalk between gut microbiome and immunology in the management of ischemic brain injury.

  2021cites this paper
• Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury.

  2021cites this paper
• Compound 21, a Direct AT2R Agonist, Induces IL-10 and Inhibits Inflammation in Mice Following Traumatic Brain Injury

  2021cites this paper
• The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential

  2020cites this paper
• The Other Angiotensin II Receptor: AT2R as a Therapeutic Target.

  2020cites this paper
• Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease

  2020cites this paper
• miR-217-regulated MEF2D-HDAC5/ND6 signaling pathway participates in the oxidative stress and inflammatory response after cerebral ischemia.

  2020cites this paper
• Brain Renin–Angiotensin System at the Intersect of Physical and Cognitive Frailty

  2020cites this paper
• Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists.

  2020cites this paper
• Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization

  2019cites this paper
• Dose–response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke

  2019cites this paper
• Recent advances in the development of neuroprotective agents and therapeutic targets in the treatment of cerebral ischemia.

  2019cites this paper
• Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

  2019cites this paper
• Angiotensin AT2 receptor–induced interleukin-10 attenuates neuromyelitis optica spectrum disorder–like pathology

  2019cites this paper
• AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.

  2019cites this paper
• Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular–Subventricular Zone

  2019cites this paper
• Evidence of AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts and its Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

  2019cites this paper
• Advance in neuroprotective therapy for ischemic stroke

  2018cites this paper
• Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage

  2018cites this paper
• Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons.

  2018cites this paper
• Neuroprotection via AT2 receptor agonists in ischemic stroke.

  2018cites this paper
• S‐nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis

  2018cites this paper
• Within the Brain: The Renin Angiotensin System

  2018cites this paper
• Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury.

  2018cites this paper
• Cellular Inflammatory Responses

  2018cites this paper
• Damage-Associated Molecular Patterns in Human Diseases

  2018cites this paper
• Hypothermia and brain inflammation after cardiac arrest

  2018cites this paper
• Activation of PD-1 Protects Intestinal Immune Defense Through IL-10/miR-155 Pathway After Intestinal Ischemia Reperfusion

  2018cites this paper
• Cell-Specific Protective Signaling Induced by the Novel AT2R-Agonist NP-6A4 on Human Endothelial and Smooth Muscle Cells

  2018cites this paper
• Validation of Brain Angiotensin System Blockade as a Novel Drug Target in Pharmacological Treatment of Neuropsychiatric Disorders

  2017cites this paper
• The renin–angiotensin system: a possible new target for depression

  2017cites this paper
• Losartan protects against cerebral ischemia/reperfusion‐induced apoptosis through &bgr;‐arrestin1‐mediated phosphorylation of Akt

  2017cites this paper
• Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium

  2017cites this paper
• Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli

  2017cites this paper