Determination of 7 alpha-hydroxy-4-cholesten-3-one level in plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in human as an index of bile acid biosynthesis.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of chromatography. B, Biomedical applications

• Publication date

  1994-05-13

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0378-4347(94)00107-3PMID 8081463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Simultaneous determination of mevalonate and 7 alpha-hydroxycholesterol in human plasma by gas chromatography-mass spectrometry as indices of cholesterol and bile acid biosynthesis.

  1993cited by this paper
• The plasma level of 7 alpha-hydroxy-4-cholesten-3-one reflects the activity of hepatic cholesterol 7 alpha-hydroxylase in man.

  1991cited by this paper
• Simultaneous assay of the activities of two key enzymes in cholesterol metabolism by gas chromatography-mass spectrometry.

  1991cited by this paper
• The plasma level of 7α‐hydroxy‐4‐cholesten‐3‐one reflects the activity of hepatic cholesterol 7α‐hydroxylase in man

  1991cited by this paper
• Simultaneous determination of keto and non-keto bile acids in human serum by gas chromatography with selected ion monitoring.

  1990cited by this paper
• Esterified and total 7 alpha-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis.

  1990cited by this paper
• Effects of bile acid administration on bile acid synthesis and its circadian rhythm in man

  1988cited by this paper
• Levels of 7α‐hydroxy‐4‐cholesten‐3‐one in plasma reflect rates of bile acid synthesis in man

  1988cited by this paper
• Levels of 7 alpha-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man.

  1988cited by this paper
• Accumulation of 7α‐hydroxy‐4‐cholesten‐3‐one and cholesta‐4,6‐dien‐3‐one in patients with cerebrotendinous xanthomatosis: Effect of treatment with chenodeoxycholic acid

  1987cited by this paper
• On the possible use of the serum level of 7 alpha-hydroxycholesterol as a marker for increased activity of the cholesterol 7 alpha-hydroxylase in humans.

  1987cited by this paper
• Regulation of bile acid synthesis in man. Presence of a diurnal rhythm.

  1983cited by this paper
• Methods for cosinor-rhythmometry.

  1979cited by this paper
• Cholesterol 7 alpha-hydroxylase.

  1977cited by this paper
• The action of cholesterol:oxygen oxidoreductase on cholest-5-ene-3beta, 7alpha-diol and the enzymatic preparation of the labeled cholest-4-en-7alpha-ol-3-one.

  1974cited by this paper
• A New Procedure for the Extraction of Unconjugated Steroids from Plasma and Urine

  1973cited by this paper
• Relationship between diurnal variations in biosynthesis of cholesterol and bile acids.

  1972cited by this paper
• Effect of Biliary Drainage on Individual Reactions in the Conversion of Cholesterol to Taurocholic Acid

  1967cited by this paper
• Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.

  1967cited by this paper

• A simple surrogate approach for the quantitation of C4 (7α-hydroxy-4-cholesten-3-one) in human serum via LC-MS/MS and its application in a clinical study.

  2025cites this paper
• Development and validation of a novel 7α-hydroxy-4-cholesten-3-one (C4) liquid chromatography tandem mass spectrometry method and its utility to assess pre-analytical stability

  2024cites this paper
• From Dietary Cholesterol to Blood Cholesterol, Physiological Lipid Fluxes, and Cholesterol Homeostasis

  2022cites this paper
• Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations

  2019cites this paper
• Cholesterol Metabolism Is Enhanced in the Liver and Brain of Children With Citrin Deficiency

  2018cites this paper
• A simple, fast, sensitive and robust LC-MS/MS bioanalytical assay for evaluating 7α-hydroxy-4-cholesten-3-one biomarker in a clinical program.

  2016cites this paper
• Oxysterols: From cholesterol metabolites to key mediators.

  2016cites this paper
• Determination of Key Intermediates in Cholesterol and Bile Acid Biosynthesis by Stable Isotope Dilution Mass Spectrometry

  2008cites this paper
• Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS.

  2007cites this paper
• Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption

  2005cites this paper
• Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment.

  2005cites this paper
• Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis.

  2005cites this paper
• Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies.

  2005cites this paper
• Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.

  2004cites this paper
• Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography--mass spectrometry.

  2004cites this paper
• Pituitary control of lipoprotein and bile acid metabolism in male rats: growth hormone effects are not mediated by prolactin.

  2004cites this paper
• Significance of plasma 7α-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits☆

  2004cites this paper
• Origin of oxysterols in hepatic bile of patients with biliary infection

  2003cites this paper
• Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one.

  2002cites this paper
• The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function.

  2001cites this paper
• The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

  2001cites this paper
• Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

  2001cites this paper
• Oxysterols: modulators of cholesterol metabolism and other processes.

  2000cites this paper
• Studies on Drug Metabolism by Gas Chromatography-Mass Spectrometry and it's Related Technique

  2000cites this paper
• Plasma levels of mevalonate and 7α‐hydroxy‐4‐cholesten‐3‐one in chronic liver disease

  1999cites this paper
• Determination of 7alpha-hydroxycholesterol in dog plasma by high-performance liquid chromatography with fluorescence detection.

  1998cites this paper
• Simultaneous determination of plasma mevalonate and 7 α‐hydroxy‐4‐cholesten‐3‐one levels in hyperlipoproteinemia: Convenient indices for estimating hepatic defects of cholesterol and bile acid syntheses and biliary cholesterol supersaturation

  1997cites this paper
• Short-term effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor on cholesterol and bile acid synthesis in humans

  1997cites this paper
• Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans.

  1996cites this paper
• The inhibitory effects of dai-chai-hu-tang (dai-saiko-to) extract on supersaturated bile formation in cholesterol gallstone disease.

  1996cites this paper
• Serum concentrations of 7α‐hydroxy‐4‐cholesten‐3‐one reflect bile acid synthesis in humans

  1996cites this paper
• Review of progress in sterol oxidations: 1987–1995

  1996cites this paper
• Accumulation of 7α-hydroxycholesterol in liver tissue of patients with cholesterol gallstones

  1995cites this paper
• Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit

  1995cites this paper
• Primary dual defect of cholesterol and bile acid metabolism in liver of patients with intrahepatic calculi.

  1995cites this paper
• Accumulation of 7 alpha-hydroxycholesterol in liver tissue of patients with cholesterol gallstones.

  1995cites this paper