The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2007-12-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0707465104PMID 18056636PMCID PMC2148390
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain.

  2007cited by this paper
• The neuroendocrine system of invertebrates: a developmental and evolutionary perspective.

  2006cited by this paper
• Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis.

  2006cited by this paper
• D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm.

  2006cited by this paper
• A critical role of teashirt for patterning the ventral epidermis is masked by ectopic expression of tiptop, a paralog of teashirt in Drosophila.

  2005cited by this paper
• Origin and development of GnRH neurons.

  2005cited by this paper
• Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster

  2005cited by this paper
• The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila.

  2005cited by this paper
• Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs

  2005cited by this paper
• A three‐dimensional atlas of pituitary gland development in the zebrafish

  2005cited by this paper
• Evolutionary origins of vertebrate placodes: insights from developmental studies and from comparisons with other deuterostomes.

  2005cited by this paper
• Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells

  2004cited by this paper
• Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass.

  2004cited by this paper
• A New Model for Olfactory Placode Development

  2004cited by this paper
• Molecular anatomy of placode development in Xenopus laevis.

  2004cited by this paper
• The Endocrine Regulation of Aging by Insulin-like Signals

  2003cited by this paper
• Molecular markers for identified neuroblasts in the developing brain of Drosophila

  2003cited by this paper
• Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis

  2003cited by this paper
• Genetic control of Drosophila nerve cord development.

  2003cited by this paper
• The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila

  2003cited by this paper
• Tissue-Specific Regulation of Retinal and Pituitary Precursor Cell Proliferation

  2002cited by this paper
• Ablation of Insulin-Producing Neurons in Flies: Growth and Diabetic Phenotypes

  2002cited by this paper
• Analysis of the Cre‐mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

  2000cited by this paper
• Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless.

  2000cited by this paper
• Gene expression pattern cSix 4 , a member of the six gene family of transcription factors , is expressed during placode and somite development

  1999cited by this paper
• Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies.

  1999cited by this paper
• Six class homeobox genes in drosophila belong to three distinct families and are involved in head development.

  1999cited by this paper
• GFP-tagged balancer chromosomes for Drosophila melanogaster.

  1999cited by this paper
• Lineage-tracing cells born in different domains along the PD axis of the developing Drosophila leg.

  1999cited by this paper
• Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia.

  1998cited by this paper
• The beta cell transcription factors and development of the pancreas.

  1997cited by this paper
• The β cell transcription factors and development of the pancreas

  1997cited by this paper
• Asymmetric segregation of the homeodomain protein Prospero duringDrosophila development

  1995cited by this paper
• Altered pulsatile gonadotropin signaling in nutritional deficiency in the male.

  1995cited by this paper
• Phylogeny and ontogeny of the neuroendocrine cells of the gastrointestinal tract.

  1993cited by this paper
• Origins of the insect enteric nervous system: differentiation of the enteric ganglia from a neurogenic epithelium.

  1991cited by this paper
• Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila.

  1991cited by this paper

• An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA

  2026cites this paper
• Utility of Drosophila for studying hypoxia-inducible factor (HIF) in neurodegenerative diseases: Advantages versus limitations.

  2025cites this paper
• The Integrative Physiology of Hormone Signaling: Insights from Insect models.

  2025cites this paper
• Understanding diabetes and its complications through the lens of Drosophila.

  2025cites this paper
• Excess dietary sugar impairs Drosophila adult stem cells via elevated ROS-JNK signaling.

  2023cites this paper
• Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells

  2022cites this paper
• Nutrient Sensing via Gut in Drosophila melanogaster

  2022cites this paper
• Inter-organ regulation by the brain in Drosophila development and physiology

  2022cites this paper
• New resources for the Drosophila 4th chromosome: FRT101F enabled mitotic clones and Bloom syndrome helicase enabled meiotic recombination

  2022cites this paper
• Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation of Drosophila Insulin-Producing Cells

  2021cites this paper
• The Glucagon-Like Adipokinetic Hormone in Drosophila melanogaster – Biosynthesis and Secretion

  2021cites this paper
• Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function

  2021cites this paper
• Drosophila melanogaster (Meigen, 1830): A Potential Model for Human Diseases

  2021cites this paper
• The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress

  2021cites this paper
• Sex-biased regulation of body size by nutrient-responsive signaling pathways in Drosophila

  2021cites this paper
• Insects as a New Complex Model in Hormonal Basis of Obesity

  2021influential citation
• The gut hormone Allatostatin C regulates food intake and metabolic homeostasis under nutrient stress

  2020cites this paper
• Control of lifespan and survival by Drosophila NF-κB signaling through neuroendocrine cells and neuroblasts

  2020cites this paper
• Development of the Drosophila melanogaster embryonic CNS

  2020cites this paper
• Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions

  2020cites this paper
• Growth regulation by amino acid transporters in Drosophila larvae

  2020cites this paper
• Endocrine fine-tuning of daily locomotor activity patterns under non-starving conditions in Drosophila

  2020cites this paper
• Metabolism and growth adaptation to environmental conditions in Drosophila

  2020cites this paper
• Diversification of metazoan Kexin-like proprotein convertases: insights from the leech Helobdella

  2019cites this paper
• Regulation of insulin and adipokinetic hormone/glucagon production in flies

  2019cites this paper
• Drosophila as a model to study obesity and metabolic disease

  2018cites this paper
• Adult‐specific insulin‐producing neurons in Drosophila melanogaster

  2018cites this paper
• A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion

  2018cites this paper
• Drosophila FIT is a protein-specific satiety hormone essential for feeding control

  2017cites this paper
• The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling.

  2016cites this paper
• Extracellular CADM1 interactions influence insulin secretion by rat and human islet β-cells and promote clustering of syntaxin-1.

  2016cites this paper
• Lineage Reprogramming: A Promising Road for Pancreatic β Cell Regeneration.

  2016cites this paper
• The Systemic Control of Growth.

  2015cites this paper
• Hexapoda: A Drosophila’s View of Development

  2015cites this paper
• Regulation of Sleep by Insulin-like Peptide System in Drosophila melanogaster.

  2015cites this paper
• Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth.

  2015cites this paper
• Origin and specification of the brain leucokinergic neurons of Drosophila: Similarities to and differences from abdominal leucokinergic neurons

  2014cites this paper
• Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila

  2014influential citation
• Effect of Insulin‐Induced Hypoglycaemia on the Central Nervous System: Evidence from Experimental Studies

  2014cites this paper
• Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

  2014influential citation
• The Drosophila Kctd‐family homologue Kctd12‐like modulates male aggression and mating behaviour

  2014influential citation
• Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain

  2014cites this paper
• Insulin-Like Peptides

  2013cites this paper
• Dilp2 neurosecretory cells regulate behaviour and metabolism through a CREB dependent pathway in Drosophila

  2013cites this paper
• Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster★

  2013cites this paper
• Control of cell identity in pancreas development and regeneration.

  2013cites this paper
• The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon Secretion

  2013cites this paper
• Of flies and men: insights on organismal metabolism from fruit flies

  2013cites this paper
• Regulation of Aggression by Obesity-Linked Genes TfAP-2 and Twz Through Octopamine Signaling in Drosophila

  2013cites this paper
• Neuronal Cbl Controls Biosynthesis of Insulin-Like Peptides in Drosophila melanogaster

  2012cites this paper
• Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression

  2012influential citation
• Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation

  2012cites this paper
• Homology of insect corpora allata and vertebrate adenohypophysis?

  2012cites this paper
• The Small GTPase Rheb Affects Central Brain Neuronal Morphology and Memory Formation in Drosophila

  2012cites this paper
• Insulin-Like Peptides: Structure, Signaling, and Function

  2012cites this paper
• Comparative Endocrinology of Aging and Longevity Regulation

  2011cites this paper
• Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis

  2011cites this paper
• Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

  2011cites this paper
• Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling

  2011influential citation
• Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain.

  2011cites this paper
• Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling

  2011influential citation
• Insect Tc-six4 marks a unit with similarity to vertebrate placodes.

  2011cites this paper
• Role of Central Insulin-Like Growth Factor-1 Receptor Signalling in Ageing and Endocrine Regulation

  2011cites this paper
• DILP‐producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

  2010cites this paper
• Nutrition, hormones, transcriptional regulatory networks and division of labor in honey bee colonies

  2010cites this paper
• The Systemic Control of Growth, Physiology, and Behavior by TOR Signaling in Drosophila

  2010cites this paper
• The Functions of Insulin-like Peptides in Insects

  2010cites this paper
• Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe.

  2010cites this paper
• An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.

  2010cites this paper
• Drosophila neuropeptides in regulation of physiology and behavior.

  2010cites this paper
• Adult Drosophila melanogaster as a model for the study of glucose homeostasis

  2010cites this paper
• Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

  2010cites this paper
• Dachshund homologues play a conserved role in islet cell development.

  2010influential citation
• Drosophila as a lipotoxicity model organism--more than a promise?

  2010cites this paper
• The Proprotein Convertase Encoded by amontillado (amon) Is Required in Drosophila Corpora Cardiaca Endocrine Cells Producing the Glucose Regulatory Hormone AKH

  2010cites this paper
• The role of synaptogenic synaptic adhesion molecules in insulin secretion

  2010cites this paper
• A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.

  2009cites this paper
• The Epicurean Fly: Using Drosophila Melanogaster to Study Metabolism

  2009cites this paper
• Regulation of tissue growth through nutrient sensing.

  2009cites this paper
• Insulin/IGF-like signalling, the central nervous system and aging.

  2009cites this paper
• Making metabolic decisions in Drosophila

  2009cites this paper
• Remote control of insulin secretion by fat cells in Drosophila.

  2009cites this paper
• Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain.

  2009cites this paper
• Endocrine regulation of aging and reproduction in Drosophila.

  2009cites this paper
• Postmitotic Specification of Drosophila Insulinergic Neurons from Pioneer Neurons

  2008cites this paper
• Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling

  2008cites this paper
• Fly-let biology and the high protein/low carb diet.

  2008cites this paper
• TORCing up metabolic control in the brain.

  2008cites this paper
• Proteins of Flies and Men: Insights on Organismal Metabolism from Fruit Flies O P I N I O N Open Access

  year unknowncites this paper