Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Seizure

• Publication date

  2018-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.seizure.2018.03.009PMID 29547827
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

  2017cited by this paper
• In vitro and in silico evaluation of chromene based aroyl hydrazones as anticonvulsant agents

  2017cited by this paper
• Anticonvulsant effect of cannabinoid receptor agonists in models of seizures in developing rats

  2017cited by this paper
• The cannabinoid receptor agonist WIN55.212 reduces consequences of status epilepticus in rats.

  2016cited by this paper
• The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats.

  2016cited by this paper
• Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus.

  2016cited by this paper
• Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.

  2016cited by this paper
• Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

  2015cited by this paper
• CB2 Cannabinoid Receptors as a Therapeutic Target—What Does the Future Hold?

  2014cited by this paper
• β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice.

  2014cited by this paper
• β-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway

  2014cited by this paper
• The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice.

  2014cited by this paper
• Involvement of peripheral cannabinoid and opioid receptors in β‐caryophyllene‐induced antinociception

  2013cited by this paper
• Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.

  2013cited by this paper
• Protective effects of curcumin against lithium-pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats.

  2013cited by this paper
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic‐like actions associated with alterations in GABAA receptors

  2012cited by this paper
• The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice.

  2012cited by this paper
• Capsaicin prevents kainic acid-induced epileptogenesis in mice.

  2011cited by this paper
• Epilepsy and neuropsychiatric comorbidities

  2011cited by this paper
• Depression‐resistant endophenotype in mice overexpressing cannabinoid CB2 receptors

  2010cited by this paper
• The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets

  2008cited by this paper
• Beta-caryophyllene is a dietary cannabinoid

  2008cited by this paper
• Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats.

  2006cited by this paper
• Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.

  2005cited by this paper
• Protective effect of trans-resveratrol against kainic acid-induced seizures and oxidative stress in rats.

  2002cited by this paper
• Afterdischarge Thresholds and Kindling Rates in Dorsal and Ventral Hippocampus and Dentate Gyrus

  1977cited by this paper

• Combined and Separate Pretreatments with L-Theanine and Aerobic Exercise Modulate Cognitive Decline Following Chronic Neuroinflammation in Rats Exposed to Lipopolysaccharide

  2026cites this paper
• Antiseizure Effects of Mirtazapine in a Rat Model of Status Epilepticus Via Cannabinoid Receptor Modulation

  2025cites this paper
• GC-MS METABOLITE PROFILING, TOTAL PHENOLIC, ANTIOXIDANT ACTIVITY, AND IN SILICO APPROACH IN CHRONIC ANTI-INFLAMMATORY ETHANOL EXTRACTS OF POLYSCIAS SCUTELLARIA (BURM. F.) FOSBERG LEAVES

  2025cites this paper
• Endocannabinoid signaling in epilepsy.

  2025cites this paper
• Cannabinoid receptor 2 agonist AM1241 alleviates epileptic seizures and epilepsy-associated depression via inhibiting neuroinflammation in a pilocarpine-induced chronic epilepsy mouse model.

  2024cites this paper
• Decoding epilepsy treatment: A comparative evaluation contrasting cannabidiol pharmacokinetics in adult and paediatric populations.

  2024cites this paper
• Beta-caryophyllene in psychiatric and neurological diseases: Role of blood-brain barrier.

  2024cites this paper
• Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation

  2024cites this paper
• Discovery of New 3-(Benzo[b]Thiophen-2-yl)Pyrrolidine-2,5-Dione Derivatives as Potent Antiseizure and Antinociceptive Agents—In Vitro and In Vivo Evaluation

  2024cites this paper
• The Modulatory Effect of Exercise on the Endocannabinoid Signaling Pathway in the Epileptic Rats

  2024cites this paper
• CB2 receptor in the CNS: from immune and neuronal modulation to behavior.

  2023cites this paper
• Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABAA Receptors

  2023cites this paper
• Cannabinoid treatments in epilepsy and seizure disorders.

  2023cites this paper
• Treating Epilepsy with Natural Products: Nonsense or Possibility?

  2023cites this paper
• Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1aWT/A1783V mice, a preclinical model of Dravet syndrome.

  2023cites this paper
• β-caryophyllene cationic nanoemulsion for intranasal delivery and treatment of epilepsy: development and in vivo evaluation of anticonvulsant activity

  2023cites this paper
• A review on ethnobotany, phytochemistry, and pharmacology of the genus Didymocarpus wall. (Gesneriaceae).

  2022cites this paper
• Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures

  2022influential citation
• Chemical profiling of Cannabis varieties cultivated for medical purposes in southeastern Brazil.

  2022cites this paper
• Influence of methadone on the anticonvulsant efficacy of valproate sodium gabapentin against maximal electroshock seizure in mice by regulation of brain MDA TNF-α

  2022cites this paper
• Comparison of intranasal and intraperitoneal administration of Eugenia caryophyllata (clove) essential oil on spatial memory, anxiety-like behavior and locomotor activity in a pilocarpine-induced status epilepticus rat model

  2022cites this paper
• III. IKERGAZTE

  2022cites this paper
• Anticonvulsant activity of β-caryophyllene in association with pregabalin in a seizure model in rats.

  2021cites this paper
• Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome.

  2021cites this paper
• Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.

  2021cites this paper
• Targeting endocannabinoid system in epilepsy: for good or for bad.

  2021cites this paper
• Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model.

  2020cites this paper
• Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

  2020cites this paper
• A Systematic Review of Essential Oils and the Endocannabinoid System: A Connection Worthy of Further Exploration

  2020cites this paper
• Constituents of Cannabis Sativa.

  2020cites this paper
• Progress in brain cannabinoid CB2 receptor research: From genes to behavior

  2019cites this paper
• Nature brings new avenues to the therapy of central nervous system diseases—An overview of possible treatments derived from natural products

  2019cites this paper
• Drug-drug interactions between antiepileptics and cannabinoids

  2019cites this paper
• CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus

  2019cites this paper
• β‐Caryophyllene, a dietary terpenoid, inhibits nicotine taking and nicotine seeking in rodents

  2019cites this paper
• β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

  2019cites this paper
• Exploiting cannabinoid and vanilloid mechanisms for epilepsy treatment.

  2019cites this paper
• Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

  2019influential citation
• Reduced cannabinoid 2 receptor activity increases susceptibility to induced seizures in mice

  2019cites this paper
• The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus.

  2018cites this paper