Mediators of Weight Loss Maintenance in the Keep It Off Trial

BackgroundAn important step toward enhancing the efficacy of weight loss maintenance interventions is identifying the pathways through which successful interventions such as the Keep It Off trial have worked.PurposeThis study aimed to assess the viability of mediated relationships between the Keep It Off Guided intervention, conceptually and empirically grounded potential mediators, and weight. Repeated measurement of mediators and weight enabled documentation of the temporal ordering of intervention delivery and changes in mediators and in weight among participants randomized to the Guided intervention or Self-Directed comparison group.MethodsTotal, direct, and indirect effects of the Guided intervention on weight change were calculated and tested for significance. Indirect effects were comprised of the influence of the intervention on three change scores for each mediator and the relationship between mediator changes and weight changes 6 months later.ResultsGuided intervention participants regained about 2% less weight over 24 months than Self-Directed participants. Starting daily self-weighing accounted for the largest share of this difference, followed by not stopping self-weighing.ConclusionsDaily self-weighing mediated 24-month weight loss maintenance.Trial Registration NumberThe trial is registered with ClinicalTrials.gov (Identifier: NCT00702455 www.clinicaltrials.gov/ct2/show/NCT00702455).

• Publication year

  2017

• Venue

  Annals of Behavioral Medicine

• Publication date

  2017-12-12

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s12160-017-9917-xPMID 28508330PMCID 5685932
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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