Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Toxicology and Applied Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.taap.2009.09.018PMID 19800904PMCID PMC3221650
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.

  2009cited by this paper
• Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.

  2009cited by this paper
• l-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction

  2009cited by this paper
• Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration1

  2008cited by this paper
• Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.

  2008cited by this paper
• Treatment with the arginase inhibitor Nω-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat

  2008cited by this paper
• Arginase blockade protects against hepatic damage in warm ischemia-reperfusion.

  2008cited by this paper
• Developmental changes in arginase expression and activity in the lung.

  2008cited by this paper
• Alterations of the arginine metabolome in asthma.

  2008cited by this paper
• Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

  2008cited by this paper
• Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease.

  2008cited by this paper
• Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism.

  2007cited by this paper
• Arginase Modulates NF-κB Activity via a Nitric Oxide–Dependent Mechanism

  2007cited by this paper
• Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.

  2007cited by this paper
• Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).

  2007cited by this paper
• Liver I/R injury is improved by the arginase inhibitor, Nω-hydroxy-nor-l-arginine (nor-NOHA)

  2007cited by this paper
• Nitric Oxide Signaling via Nuclearized Endothelial Nitric-oxide Synthase Modulates Expression of the Immediate Early Genes iNOS and mPGES-1*

  2006cited by this paper
• Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

  2006cited by this paper
• Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.

  2006cited by this paper
• Mitochondrial Arginase II Modulates Nitric-Oxide Synthesis through Nonfreely Exchangeable l-Arginine Pools in Human Endothelial Cells

  2006cited by this paper
• Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice

  2006cited by this paper
• Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway.

  2005cited by this paper
• Arginine in asthma and lung inflammation.

  2004cited by this paper
• Decreased arginine bioavailability and increased serum arginase activity in asthma.

  2004cited by this paper
• cNOS-iNOS paradigm and arginase in asthma.

  2003cited by this paper
• Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

  2003cited by this paper
• Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

  2003cited by this paper
• Airway fibrosis in a mouse model of airway inflammation.

  2003cited by this paper
• Translational Control of Inducible Nitric Oxide Synthase by IL-13 and Arginine Availability in Inflammatory Macrophages 1

  2003cited by this paper
• Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.

  2003cited by this paper
• Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox

  2003cited by this paper
• Arginase I induction in macrophages, triggered by Th2‐type cytokines, supports the growth of intracellular Leishmania parasites

  2002cited by this paper
• Increased arginase activity underlies allergen‐induced deficiency of cNOS‐derived nitric oxide and airway hyperresponsiveness

  2002cited by this paper
• Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness.

  2002cited by this paper
• Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice.

  2002cited by this paper
• The Inhibition of Arginase by N ω-Hydroxy-l-Arginine Controls the Growth of Leishmania Inside Macrophages

  2001cited by this paper
• Sustained Nitric Oxide Production in Macrophages Requires the Arginine Transporter CAT2*

  2001cited by this paper
• Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity

  2000cited by this paper
• Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells

  2000cited by this paper
• Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters.

  2000cited by this paper
• Distinct Roles of Thioredoxin in the Cytoplasm and in the Nucleus

  1999cited by this paper
• Arginine metabolism: nitric oxide and beyond.

  1998cited by this paper
• An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen

  1998influential reference
• Nitric oxide synthesis inhibitors induce airway hyperresponsiveness in the guinea pig in vivo and in vitro. Role of the epithelium.

  1993cited by this paper
• Rapid analysis of nutritionally important free amino acids in serum and organs (liver, brain, and heart) by liquid chromatography of precolumn phenylisothiocyanate derivatives.

  1990cited by this paper

• Arginine as host directed therapy in tuberculosis: insights from modulating arginine metabolism by supplementation and arginase inhibition

  2025cites this paper
• Oral L-Arginine treatment attenuates Cryptococcus neoformans extrapulmonary dissemination and disease progression

  2025cites this paper
• Sugar and arginine facilitate oral tolerance by ensuring the functionality of tolerogenic immune cell subsets in the intestine.

  2024cites this paper
• Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity.

  2024cites this paper
• Effectiveness of Trigger Point Dry Needling on Lumbosacral Radiculopathy among Indian Homemakers: A Randomized Controlled Trial

  2021cites this paper
• L-arginine supplementation in severe asthma.

  2020cites this paper
• Pharmacological Screening Identifies SHK242 and SHK277 as Novel Arginase Inhibitors with Efficacy against Allergen-Induced Airway Narrowing In Vitro and In Vivo

  2020cites this paper
• Efficacy of Trigger Point Injections in Patients with Lumbar Disc Hernia without Indication for Surgery

  2018cites this paper
• Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization in vitro and in vivo

  2018cites this paper
• The Regulation of IL-33 and Arginase-1 by Oncostatin M in Mouse Lung Systems

  2017cites this paper
• Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen

  2017cites this paper
• Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice

  2017cites this paper
• Common and differential roles of inducible NO synthase and poly (ADP-ribose)polymerase in allergen-induced inflammation and airway hyperresponsiveness: a potential connection to NO levels (HYP5P.320)

  2015cites this paper
• Label-free Quantitative Urinary Proteomics Identifies the Arginase Pathway as a New Player in Congenital Obstructive Nephropathy*

  2014cites this paper
• Effect of Trigger Point Injection on Lumbosacral Radiculopathy Source

  2014influential citation
• Exposure of cardiac microvascular endothelial cells to harmful stimuli : a study of the cellular responses and mechanisms

  2014cites this paper
• Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats.

  2014cites this paper
• Beneficial effects of arginase inhibition and inhaled L-arginine administration on airway histology in a murine model of chronic asthma.

  2014cites this paper
• Airway arginase expression and Nω-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains.

  2014cites this paper
• Novel therapeutic strategies for adult obese asthmatics.

  2014cites this paper
• Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.

  2013cites this paper
• Self-Assembling Nanoparticles Containing Dexamethasone as a Novel Therapy in Allergic Airways Inflammation

  2013cites this paper
• Self-assembling containing as a novel therapy in allergic airways inflammation.

  2013cites this paper
• Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.

  2013cites this paper
• Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

  2013cites this paper
• A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.

  2013cites this paper
• Efficacy of Different Nitric Oxide-Based Strategies in Preventing Experimental Cerebral Malaria by Plasmodium berghei ANKA

  2012cites this paper
• Competition of NO synthases and arginase in the airways hyperreactivity.

  2011cites this paper
• Role of Arginase in Impairing Relaxation of Lung Parenchyma of Hyperoxia-Exposed Neonatal Rats

  2011cites this paper
• Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma

  2011cites this paper
• Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma

  2011cites this paper
• Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?

  2010cites this paper
• Not Inflammation Exposure-Induced Pulmonary Fibrosis but Synthase in Chronic Allergen Requirement for Inducible Nitric Oxide

  2010cites this paper
• Nitric oxide--the endothelium-derived relaxing factor and its role in endothelial functions.

  2010cites this paper
• Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.

  2010cites this paper
• Requirement for Inducible Nitric Oxide Synthase in Chronic Allergen Exposure-Induced Pulmonary Fibrosis but Not Inflammation

  2010cites this paper