Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cardiovascular Drug Reviews

• Publication date

  2006-06-07

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/J.1527-3466.2004.TB00143.XPMID 15492770
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular Selectivity of Felodipine

  2012cited by this paper
• Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery

  2003cited by this paper
• Time-dependent Cardioprotection With Calcium Antagonism and Experimental Studies With Clevidipine in Ischemic-reperfused Pig Hearts: Part II

  2002cited by this paper
• Time-dependent Cardioprotection With Calcium Antagonism and Experimental Studies With Clevidipine in Ischemic-reperfused Pig Hearts: Part I

  2002cited by this paper
• EFFECTS OF FENOLDOPAM, A DOPAMINE D-1 AGONIST, AND CLEVIDIPINE, A CALCIUM CHANNEL ANTAGONIST, IN ACUTE RENAL FAILURE IN ANESTHETIZED RATS

  2002cited by this paper
• Clevidipine in Adult Cardiac Surgical Patients: A Dose-finding Study

  2002influential reference
• Calcium Antagonist Clevidipine Reduces Myocardial Reperfusion Injury by a Mechanism Related to Bradykinin and Nitric Oxide

  2002cited by this paper
• Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium.

  2001cited by this paper
• Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients.

  2001cited by this paper
• Perioperative blood pressure control: a prospective survey of patient management in cardiac surgery.

  2000cited by this paper
• Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass.

  2000cited by this paper
• Clevidipine blockade of L-type Ca2+ currents: steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes.

  2000cited by this paper
• Pharmacokinetics and Arteriovenous Differences in Clevidipine Concentration following a Short- and a Long-term Intravenous Infusion in Healthy Volunteers

  2000influential reference
• Coronary and systemic hemodynamic effects of clevidipine, an ultra‐short‐acting calcium antagonist, for treatment of hypertension after coronary artery surgery

  2000influential reference
• Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: an experimental study with the ultrashort-acting calcium antagonist clevidipine.

  2000cited by this paper
• TREATMENT OF PERIOPERATIVE HYPERTENSION

  1999cited by this paper
• Circulatory effects and pharmacology of clevidipine, a novel ultra short acting and vascular selective calcium antagonist, in hypertensive humans.

  1999cited by this paper
• Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine.

  1999cited by this paper
• In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man.

  1999cited by this paper
• Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers.

  1999cited by this paper
• Calcium Antagonists for Perioperative Blood Pressure Control

  1998influential reference
• Myocardial protection during ischemia and reperfusion

  1998cited by this paper
• Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs.

  1998cited by this paper
• A fresh look at reperfusion injury.

  1998cited by this paper
• The Vasodilator Effects of Clevidipine on Human Internal Mammary Artery

  1997cited by this paper
• Characterization of endothelium‐derived relaxing factors released by bradykinin in human resistance arteries

  1997cited by this paper
• Reperfusion injury.

  1996cited by this paper
• The ideal agent for perioperative hypertension and potential cytoprotective effects

  1993cited by this paper
• Quantification of effect delay and acute tolerance development to morphine in the rat.

  1993cited by this paper
• Antihypertensive drug treatment in the perioperative period.

  1993influential reference
• Antihypertensive drug treatment in the perioperative period

  1993cited by this paper
• Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs.

  1992cited by this paper
• Reperfusion induced injury: manifestations, mechanisms, and clinical relevance.

  1992cited by this paper
• Evaluation of the effects of felodipine, verapamil and hydralazine on the survival rate of rats subjected to lethal effects of oxygen free radicals

  1992cited by this paper
• Calcium Antagonists in Clinical Medicine

  1992cited by this paper
• Reperfusion injury.

  1991cited by this paper
• Mechanisms of myocardial “stunning”

  1991cited by this paper
• Reperfusion-induced injury manifestations, mechanisms, and clinical relevance.

  1991cited by this paper
• Pharmacokinetics, pharmacodynamics, and minimum effective clinical dose of intravenous nicardipine

  1990cited by this paper
• Mechanism of Myocardial “Stunning”

  1990cited by this paper
• Pharmacokinetics and biotransformation of 1,4-dihydropyridine calcium antagonists

  1990cited by this paper
• Mechanisms of Ca2+ overload in reperfused ischemic myocardium.

  1990cited by this paper
• Reperfusion injury and its pharmacologic modification.

  1989cited by this paper
• Postcardiac surgical hypertension.

  1988influential reference
• Pharmacokinetics and Blood Pressure Effects of Felodipine in Elderly Hypertensive Patients

  1988cited by this paper
• Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans

  1987cited by this paper
• Myocardial consequences of reperfusion.

  1987cited by this paper
• Myocardial reperfusion: a double-edged sword?

  1985cited by this paper
• Baroreceptor Reflex Control of Heart Rate during Isoflurane Anesthesia in Humans

  1984cited by this paper
• Progress in Drug Metabolism

  1976cited by this paper
• Systemic hypertension following myocardial revascularization.

  1973cited by this paper
• Diminished Baroreflex Sensitivity in High Blood Pressure

  1969cited by this paper

• Analytical Quality by Design Assisted Spectroscopic Method Development for Estimation of Clevidipine Butyrate in Synthetic Mixture in Application to Greenness Study

  2026cites this paper
• Comparative Bioequivalence Study of 2 Clevidipine Formulations in Healthy Chinese participants: A Single‐Dose, 2‐Period Crossover Trial

  2025cites this paper
• Crystal structure of chloromethyl 2-[2-(2,6-dichlorophenylamino)phenyl]acetate

  2025cites this paper
• Effect of glyceryl trinitrate and clevidipine administration on CT angiogram findings in dogs undergoing prostatic artery embolization for prostatic carcinoma

  2024cites this paper
• Mitral Regurgitation Complicated by Cardiogenic Shock: Reassessing Risk Stratification and Therapeutic Strategies.

  2024cites this paper
• Comparison of clevidipine vs nicardipine in the treatment of hypertensive urgency and emergency in critically ill patients.

  2024cites this paper
• Catalytic Access to Chiral Lactams via Nucleophilic Dearomatisations of Pyridine Derivatives.

  2022cites this paper
• Ca2+ Channel Inhibitors

  2021cites this paper
• Catalytic enantioselective synthesis of 1,4-dihydropyridines via the addition of C(1)-ammonium enolates to pyridinium salts

  2021cites this paper
• The Current Role of Clevidipine in the Management of Hypertension

  2021cites this paper
• Development and validation of samples stabilization strategy and LC-MS/MS method for simultaneous determination of clevidipine and its primary metabolite in human plasma: Application to clinical pharmacokinetic study in Chinese healthy volunteers.

  2020cites this paper
• Management of Challenging Cardiopulmonary Bypass Separation.

  2020cites this paper
• Intraoperative and Early Postoperative Management of Patients Undergoing Minimally Invasive Left Ventricular Assist Device Implantation.

  2020cites this paper
• Severe Hypertension After Cardiac Transplantation

  2019cites this paper
• Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries

  2019cites this paper
• Postoperative Management in Patients with Pheochromocytoma and Paraganglioma

  2019cites this paper
• Difficult Decisions in Cardiothoracic Critical Care Surgery: An Evidence-Based Approach

  2019cites this paper
• Controlled hypotensive anesthesia for endoscopic endonasal repair of cerebrospinal fluid rhinorrhea: A comparison between clevidipine and esmolol: Randomized controlled study

  2018cites this paper
• Therapeutic Approach to Hypertension Urgencies and Emergencies in the Emergency Room

  2018cites this paper
• Revisiting Clevidipine Experience in the Pediatric Population: a Perioperative Perspective

  2016cites this paper
• The effect of erythropoietin on calcium levels during hypoxia reoxygenation injury in rats

  2016cites this paper
• Nouveaux médicaments dans l’insuffisance cardiaque aiguë

  2016cites this paper
• Evaluation and treatment of hypertensive crises in children

  2016cites this paper
• Evaluation and treatment of hypertensive crises in children Please share how this access benefits you. Your story matters

  2016cites this paper
• Therapeutic Interchange of Clevidipine For Sodium Nitroprusside in Cardiac Surgery.

  2016cites this paper
• Perioperative Use of Clevidipine: A Systematic Review and Meta-Analysis

  2016cites this paper
• High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

  2016cites this paper
• Novel Use of Clevidipine for Intraoperative Blood Pressure Management in Patients With Pheochromocytoma.

  2016cites this paper
• Downregulated StAR gene and male reproductive dysfunction caused by nifedipine and ethosuximide

  2016cites this paper
• Highly Enantioselective Nucleophilic Dearomatization of Pyridines by Anion-Binding Catalysis.

  2015cites this paper
• Structural Analysis and Quantitative Determination of Clevidipine Butyrate Impurities Using an Advanced RP-HPLC Method.

  2015cites this paper
• The Effect of Erythropoietin on Sodium During Ischemia Reperfusion Injury in Rats Ratlarda İskemi Reperfüzyon Hasari Sirasinda Eritropoietinin Sodyum Üzerine Etkisi

  2015cites this paper
• Hoch enantioselektive nukleophile Dearomatisierung von Pyridinen durch Anionenbindungskatalyse

  2015cites this paper
• Determination of clevidipine and its primary metabolite in rat plasma by a dispersive liquid-liquid microextraction method.

  2015cites this paper
• Estimating The Budget Impact Of Clevidipine For The Management Of Perioperative Blood Pressure In Cardiac Surgery: A Us Perspective

  2015cites this paper
• Clevidipine for perioperative pressure control in a child with aortic coarctation

  2015cites this paper
• Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood.

  2015cites this paper
• Clevidipine: A Review of Its Use for Managing Blood Pressure in Perioperative and Intensive Care Settings

  2014cites this paper
• Perioperative acute hypertension—role of Clevidipine butyrate

  2014cites this paper
• Pharmacokinetics and tissue distribution of clevidipine and its metabolite in dogs and rats

  2014cites this paper
• Quantitation of clevidipine in dog blood by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

  2014cites this paper
• Clevidipine in acute heart failure: Results of the A Study of Blood Pressure Control in Acute Heart Failure-A Pilot Study (PRONTO).

  2014cites this paper
• Clevidipine compared with nitroglycerin for blood pressure control in coronary artery bypass grafting: a randomized double-blind study

  2014cites this paper
• Pharmacokinetics and tissue distribution of clevidipine and its metabolite in dogs and rats

  2014cites this paper
• Simultaneous determination of clevidipine and its primary metabolite in dog plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study.

  2014cites this paper
• Innovative Approaches To The Management of Acute Arterial Hypertension - Clevidipine Butyrate

  2013cites this paper
• Clevidipine for Perioperative Blood Pressure Control in Infants and Children

  2013cites this paper
• Clevidipine Rapidly and Safely Reduces Blood Pressure in Acute Intracerebral Hemorrhage: The ACCELERATE Trial

  2013cites this paper
• 5. Soft Drugs

  2012cites this paper
• Perioperative management of pheochromocytoma: focus on magnesium, clevidipine, and vasopressin.

  2012cites this paper
• Pharmacokinetics, pharmacodynamics, and safety of clevidipine after prolonged continuous infusion in subjects with mild to moderate essential hypertension

  2012cites this paper
• Clevidipine: a state-of-the-art antihypertensive drug under the scope

  2012influential citation
• Optimizing drug therapy in the surgical intensive care unit.

  2012cites this paper
• Drugs for the Perioperative Control of Hypertension

  2012cites this paper
• Safety and Efficacy of Intravenous Clevidipine for the Perioperative Control of Acute Hypertension

  2011cites this paper
• Acute Kidney Injury following Cardiac Surgery: Role of Perioperative Blood Pressure Control

  2011cites this paper
• Hypertensive Emergencies in Children

  2011cites this paper
• The management of hypertensive emergencies in children after stem cell transplantation

  2011cites this paper
• Clevidipine in Acute Hypertension: The Evidence of its Therapeutic Value

  2010cites this paper
• Management of hypertensive emergencies: a drug therapy perspective for nurses.

  2010cites this paper
• Clevidipine for severe hypertension in patients with renal dysfunction: A VELOCITY trial analysis

  2010cites this paper
• Intravenous clevidipine for management of hypertension

  2010cites this paper
• [Hypertensive emergency and urgency: clinical update].

  2010cites this paper
• Efficacy of Clevidipine in Controlling Perioperative Hypertension in Neurosurgical Patients: Initial Single-center Experience

  2010cites this paper
• Clevidipine for severe hypertension in acute heart failure: a VELOCITY trial analysis.

  2010cites this paper
• Clevidipine butyrate: a promising new drug for the management of acute hypertension

  2010cites this paper
• Clevidipine for the treatment of severe hypertension in adults.

  2010cites this paper
• Role of clevidipine butyrate in the treatment of acute hypertension in the critical care setting: a review

  2010cites this paper
• O uso de clevidipina em emergência hipertensiva

  2010cites this paper
• Retrometabolism‐Based Drug Design and Targeting

  2010cites this paper
• Emergenze e urgenze ipertensive: update clinico

  2010cites this paper
• Clevidipine controls intraoperative blood pressure in an adolescent with renal failure.

  2009cites this paper
• Perioperative blood pressure management with clevidipine during coiling of cerebral artery aneurysms

  2009cites this paper
• Intravenous therapy for hypertensive emergencies, part 1.

  2009cites this paper
• Clevidipine in the treatment of perioperative hypertension: assessing safety events in the ECLIPSE trials

  2009cites this paper
• Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm—A Review of Management

  2009cites this paper
• Pharmacokinetics of 22 new molecular entity drugs approved in 2008

  2009cites this paper
• Asian Journal of Pharmacodynamics and Pharmacokinetics

  2009cites this paper
• Clevidipine: A Novel Ultra-Short-Acting Calcium Antagonist

  2009cites this paper
• New Drug Approvals: Clevidipine: An Ultra Short-Acting Calcium Channel Antagonist for Acute Hypertension

  2009cites this paper
• Porcine myocardial ischemia-reperfusion studies on cardioprotection, ventricular arrhythmia and electrophysiology

  2009cites this paper
• Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension.

  2009cites this paper
• A New Intravenous Calcium Channel Blocker Option to Treat Acute Elevations in Blood Pressure

  2009cites this paper
• Severe hypertension in children and adolescents: pathophysiology and treatment

  2009cites this paper
• Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review

  2009cites this paper
• Treatment of Acute Postoperative Hypertension in Cardiac Surgery Patients: An Efficacy Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery-2 (ESCAPE-2), a Randomized, Double-Blind, Placebo-Controlled Trial

  2008cites this paper
• The ECLIPSE Trials: Comparative Studies of Clevidipine to Nitroglycerin, Sodium Nitroprusside, and Nicardipine for Acute Hypertension Treatment in Cardiac Surgery Patients

  2008cites this paper
• The role of intravenous dihydropyridine calcium channel blockers in the perioperative management of patients undergoing coronary artery bypass surgery.

  2008cites this paper
• Clevidipine and the management of acute hypertension

  2008cites this paper
• Drug evaluation of clevidipine for acute hypertension

  2008cites this paper
• Drugs for the perioperative control of hypertension: current issues and future directions.

  2007cites this paper
• Clevidipine Effectively and Rapidly Controls Blood Pressure Preoperatively in Cardiac Surgery Patients: The Results of the Randomized, Placebo-Controlled Efficacy Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery-1

  2007influential citation
• New therapeutic perspectives with clevidipine: an ultra-short-acting intravenous Ca2+ channel blocker

  2007cites this paper
• Computer-aided retrometabolic drug design: soft drugs

  2007cites this paper
• HUMAN CYTOCHROME P 450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE

  2006influential citation
• Calcium-channel modulators for cardiovascular disease

  2006cites this paper
• HUMAN CYTOCHROME P450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE H152/81

  2006influential citation
• New insights in the pharmacological therapy of arterial hypertension

  2005cites this paper