Notch and Ikaros: Not Only Converging Players in T Cell Leukemia

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Cell Cycle

• Publication date

  2007-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.6.22.4894PMID 18032925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation

  2007cited by this paper
• Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing

  2007cited by this paper
• Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

  2006cited by this paper
• Cross talk among Notch3, pre-TCR, and Tal1 in T-cell development and leukemogenesis.

  2006cited by this paper
• A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators.

  2006cited by this paper
• Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.

  2006cited by this paper
• Notch3 and pre‐TCR interaction unveils distinct NF‐κB pathways in T‐cell development and leukemia

  2006cited by this paper
• Target Selectivity of Vertebrate Notch Proteins

  2006cited by this paper
• PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.

  2005cited by this paper
• Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line

  2005cited by this paper
• Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.

  2005cited by this paper
• The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

  2005cited by this paper
• Hes1 Directly Controls Cell Proliferation through the Transcriptional Repression of p27Kip1

  2005cited by this paper
• Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling

  2003cited by this paper
• Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis.

  2003cited by this paper
• Pre‐TCR‐triggered ERK signalling‐dependent downregulation of E2A activity in Notch3‐induced T‐cell lymphoma

  2003cited by this paper
• Hematopoietic progenitors express neural genes

  2003cited by this paper
• Haematopoietic cell-fate decisions, chromatin regulation and ikaros

  2002cited by this paper
• Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

  2002cited by this paper
• ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

  2002cited by this paper
• Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

  2002cited by this paper
• Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway.

  2002cited by this paper
• Characterization of a High-Molecular-Weight Notch Complex in the Nucleus of Notchic-Transformed RKE Cells and in a Human T-Cell Leukemia Cell Line

  2002cited by this paper
• Role of HuD and other RNA‐binding proteins in neural development and plasticity

  2002cited by this paper
• Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.

  2002cited by this paper
• The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA.

  2001cited by this paper
• Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

  2001cited by this paper
• Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

  2001cited by this paper
• Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT

  2001cited by this paper
• Notchless T cell maturation?

  2001cited by this paper
• Induction of Cyclin D1 Transcription and CDK2 Activity by Notchic: Implication for Cell Cycle Disruption in Transformation by Notchic

  2001cited by this paper
• Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.

  2001cited by this paper
• T cell fate specification and alphabeta/gammadelta lineage commitment.

  2001cited by this paper
• Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

  2001cited by this paper
• Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes.

  2000cited by this paper
• NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development.

  2000cited by this paper
• Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

  2000cited by this paper
• Neoplastic Transformation by Notch Requires Nuclear Localization

  2000cited by this paper
• Constitutive activation of NF‐κB and T‐cell leukemia/lymphoma in Notch3 transgenic mice

  2000cited by this paper
• Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Introduction: Notch signalling and choice of cell fates in development.

  1998cited by this paper
• Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment

  1998cited by this paper
• Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4.

  1998cited by this paper
• Notch signaling: direct or what?

  1998cited by this paper
• The role of the Ikaros gene in lymphocyte development and homeostasis.

  1997cited by this paper
• Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage.

  1997cited by this paper
• Notch in vertebrates.

  1997cited by this paper
• Notch activity influences the alphabeta versus gammadelta T cell lineage decision.

  1997cited by this paper
• Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.

  1996cited by this paper
• An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.

  1996cited by this paper
• Zinc finger‐mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

  1996cited by this paper
• Modulated expression of notch1 during thymocyte development.

  1996cited by this paper
• The Ikaros gene is required for the development of all lymphoid lineages.

  1994cited by this paper
• The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

  1994cited by this paper
• Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs.

  1993cited by this paper
• Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues.

  1993cited by this paper
• Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.

  1992cited by this paper
• Notch2: a second mammalian Notch gene.

  1992cited by this paper
• A homolog of Drosophila Notch expressed during mammalian development.

  1991cited by this paper
• TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

  1991cited by this paper

• Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer

  2025cites this paper
• IKAROS: from chromatin organization to transcriptional elongation control

  2023cites this paper
• Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53

  2023cites this paper
• IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling

  2021influential citation
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  2020cites this paper
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• NF-κB1 Regulates Immune Environment and Outcome of Notch-Dependent T-Cell Acute Lymphoblastic Leukemia

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• NOTCH3 Is a Prognostic Factor That Promotes Glioma Cell Proliferation, Migration and Invasion via Activation of CCND1 and EGFR

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• outcome in patients with childhood acute lymphoblastic leukemia DNA methylation for subtype classification and prediction of treatment

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  2012influential citation
• Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease.

  2011cites this paper
• Vasoactive intestinal peptide signaling axis in human leukemia.

  2011cites this paper
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  2010cites this paper
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  2008cites this paper
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  2008cites this paper
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  2008cites this paper