IL-32α suppresses colorectal cancer development via TNFR1-mediated death signaling

Inflammation is associated with cancer-prone microenvironment, leading to cancer. IL-32 is expressed in chronic inflammation-linked human cancers. To investigate IL-32α in inflammation-linked colorectal carcinogenesis, we generated a strain of mice, expressing IL-32 (IL-32α-Tg). In IL-32α-Tg mice, azoxymethane (AOM)-induced colon cancer incidence was decreased, whereas expression of TNFR1 and TNFR1-medicated apoptosis was increased. Also, IL-32α increased ROS production to induce prolonged JNK activation. In colon cancer patients, IL-32α and TNFR1 were increased. These findings indicate that IL-32α suppressed colon cancer development by promoting the death signaling of TNFR1.

• Publication year

  2015

• Venue

  OncoTarget

• Publication date

  2015-04-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.18632/ONCOTARGET.3197PMID 25909160PMCID 4496202
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• IL-32α suppresses colon cancer development by promoting TNFR1 death signaling.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• Colon cancer patients showed increased IL-32α and TNFR1 expression.

  Confidence 0.93

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• IL-32α increased ROS production, which was associated with prolonged JNK activation.

  Confidence 0.95

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• IL-32α-Tg mice showed reduced azoxymethane-induced colon cancer incidence, alongside increased TNFR1 expression and TNFR1-mediated apoptosis.

  Confidence 0.97

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

• azoxymethane-induced colon cancer

  animal model, disease model

  A chemically induced mouse model of colon carcinogenesis generated by azoxymethane exposure.

  Aliases: AOM-induced colon cancer, AOM-induced colon carcinogenesis

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• il-32α

  protein, cytokine

  An isoform of the interleukin-32 cytokine studied in transgenic mice and colon cancer tissues.

  Aliases: interleukin-32 alpha

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• jnk activation

  signaling pathway, molecular process

  Activation of the c-Jun N-terminal kinase signaling pathway in cells.

  Aliases: c-Jun N-terminal kinase activation

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• reactive oxygen species production

  molecular process, measurement outcome

  Generation of oxidant molecules inside cells, used here as a measured signaling-related outcome.

  Aliases: ROS production, ROS

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• tnfr1

  receptor, protein

  Tumor necrosis factor receptor 1, a cell-surface receptor involved in death-signaling pathways.

  Aliases: tumor necrosis factor receptor 1

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review
• tnfr1-mediated apoptosis

  cell death process, signaling outcome

  Programmed cell death triggered through TNFR1-dependent signaling.

  Aliases: TNFR1-mediated cell death

  박진우 (dztg5apj7m) extractionB (s683577b42) reviewAK (4715169a40) review

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