Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17beta-estradiol: involvement of PKC, PI3K/Akt, and MAPKs.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Physiology - Cell Physiology

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpcell.00415.2008PMID 18987249
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human mesenchymal stem cells isolated from the umbilical cord

  2008cited by this paper
• The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK

  2008cited by this paper
• Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway.

  2007cited by this paper
• Effect of Hypoxia on 2-Deoxyglucose Uptake and Cell Cycle Regulatory Protein Expression of Mouse Embryonic Stem Cells: Involvement of Ca2+ /PKC, MAPKs and HIF-1α

  2007influential reference
• Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen.

  2007cited by this paper
• EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs.

  2006cited by this paper
• Androgenic and antiandrogenic effects and expression of androgen receptor in mouse embryonic stem cells.

  2006cited by this paper
• Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action.

  2006cited by this paper
• c‐Jun and JunB Are Essential for Hypoglycemia‐Mediated VEGF Induction

  2006cited by this paper
• Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.

  2006cited by this paper
• Estradiol-17beta stimulates proliferation of mouse embryonic stem cells: involvement of MAPKs and CDKs as well as protooncogenes.

  2006cited by this paper
• Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter.

  2005cited by this paper
• Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.

  2005cited by this paper
• Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts

  2005cited by this paper
• Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways.

  2004cited by this paper
• 4-Hydroxy estradiol but not 2-hydroxy estradiol induces expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor A through phosphatidylinositol 3-kinase/Akt/FRAP pathway in OVCAR-3 and A2780-CP70 human ovarian carcinoma cells.

  2004cited by this paper
• Expression of estrogen receptor-alpha and -beta, glucocorticoid receptor, and progesterone receptor genes in human embryonic stem cells and embryoid bodies.

  2004cited by this paper
• In Vivo and In Vitro Regulation of Akt Activation in Human Endometrial Cells Is Estrogen Dependent

  2004cited by this paper
• Does Palmitoylation Target Estrogen Receptors to Plasma Membrane Caveolae?

  2003cited by this paper
• Soluble Vascular Endothelial Growth Factor Receptor 1 Inhibits Edema and Epithelial Proliferation Induced by 17β-Estradiol in the Mouse Uterus

  2003cited by this paper
• Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterus.

  2003cited by this paper
• Estrogen-receptor-dependent regulation of neural stem cell proliferation and differentiation.

  2002cited by this paper
• Effect of prolonged hydroxytamoxifen treatment of MCF‐7 cells on mitogen activated kinase cascade

  2002cited by this paper
• ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions.

  2002cited by this paper
• Inhibition of Vascular Endothelial Growth Factor/Vascular Permeability Factor Action Blocks Estrogen-Induced Uterine Edema and Implantation in Rodents1

  2002cited by this paper
• ERβ Has Nongenomic Action in Caveolae

  2002cited by this paper
• Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon.

  2002influential reference
• Stimulation of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) Protein in the Adult Rat Testis Following Ischemic Injury Occurs Without an Increase in HIF-1α Messenger RNA Expression1

  2002cited by this paper
• Synthetic estrogens-mediated activation of JNK intracellular signaling molecule

  2001cited by this paper
• PKC, p42/p44 MAPK, and p38 MAPK are required for HGF-induced proliferation of H441 cells.

  2000cited by this paper
• Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

  2000influential reference
• Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling.

  2000cited by this paper
• Estrogen Signals to the Preservation of Endothelial Cell Form and Function*

  2000cited by this paper
• p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1*

  1999cited by this paper
• Complex role of protein phosphorylation in gene activation by hypoxia.

  1997cited by this paper
• Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element.

  1997cited by this paper
• Antiestrogens: Mechanisms of action and resistance in breast cancer

  1997cited by this paper
• Structure and function of estrogen receptors.

  1995cited by this paper
• Interaction of Nucleoside Analogues with the Sodium–Nucleoside Transport System in Brush Border Membrane Vesicles from Human Kidney

  1993cited by this paper
• The human estrogen receptor has two independent nonacidic transcriptional activation functions.

  1989cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Exercise-Intervened Circulating Extracellular Vesicles Alleviate Oxidative Stress in Cerebral Microvascular Endothelial Cells Under Hypertensive Plus Hypoxic Conditions

  2025cites this paper
• Hyperostosis Frontalis Interna and Its Clinical Significance

  2025cites this paper
• 17β-estradiol promotes osteogenic differentiation of BMSCs by regulating mitophagy through ARC

  2025cites this paper
• Estrogenic actions of alkaloids: Structural characteristics and molecular mechanisms.

  2024cites this paper
• Ginsenoside Re promotes proliferation of murine bone marrow mesenchymal stem cells in vitro through estrogen-like action

  2024cites this paper
• Proliferative and Osteogenic Supportive Effect of VEGF-Loaded Collagen-Chitosan Hydrogel System in Bone Marrow Derived Mesenchymal Stem Cells

  2023cites this paper
• The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells

  2023cites this paper
• Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma

  2022cites this paper
• Looking at Mountains: Role of Sustained Hypoxia in Regulating Bone Mineral Homeostasis in Relation to Wnt Pathway and Estrogen

  2022cites this paper
• Microfluidic 3D Platform to Evaluate Endothelial Progenitor Cell Recruitment by Bioactive Materials.

  2022cites this paper
• Modulatory Effects of Estradiol and Its Mixtures with Ligands of GPER and PPAR on MAPK and PI3K/Akt Signaling Pathways and Tumorigenic Factors in Mouse Testis Explants and Mouse Tumor Leydig Cells

  2022cites this paper
• In search of elixir: Pharmacological agents against stem cell senescence

  2021cites this paper
• Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis

  2020cites this paper
• Looking for immortality: Review of phytotherapy for stem cell senescence

  2020cites this paper
• Huaier shows anti‐cancer activities by inhibition of cell growth, migration and energy metabolism in lung cancer through PI3K/AKT/HIF‐1α pathway

  2020cites this paper
• Nanospheres loaded with curcumin promote gut epithelial motility through F-actin-related migration signaling events.

  2020cites this paper
• Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing.

  2020cites this paper
• Mapping human serum-induced gene networks as a basis for the creation of biomimetic periosteum for bone repair.

  2020cites this paper
• Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation

  2020cites this paper
• Hypoxia-inducible factor-1α: A promising therapeutic target for vasculopathy in diabetic retinopathy.

  2020cites this paper
• Perfusion bioreactor culture of adipose-derived stromal cells on decellularized adipose tissue scaffolds enhances in vivo regeneration

  2020cites this paper
• Perfusion bioreactor culture of adipose-derived stromal cells on decellularized adipose tissue scaffolds enhances in vivo regeneration

  2020cites this paper
• The Impact of Patient Sex on the Response to Intramyocardial Mesenchymal Stem Cell Administration in Patients with Non-Ischemic Dilated Cardiomyopathy.

  2020cites this paper
• Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis.

  2020cites this paper
• The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy

  2019cites this paper
• Role of HIF1α Regulatory Factors in Stem Cells

  2019cites this paper
• Estradiol induces cell proliferation in MCF‑7 mammospheres through HER2/COX‑2.

  2019cites this paper
• Secretion, migration and adhesion as key processes in the therapeutic activity of mesenchymal stem cells.

  2019cites this paper
• Effects of Physical, Chemical, and Biological Stimulus on h-MSC Expansion and Their Functional Characteristics

  2019cites this paper
• The effects of transplanted mesenchymal stem cells treated with 17-b estradiol on experimental autoimmune encephalomyelitis

  2019cites this paper
• Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat

  2019cites this paper
• FGF-17 from Hypoxic Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Is Responsible for Maintenance of Cell Proliferation at Late Passages

  2019cites this paper
• Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

  2019cites this paper
• The effect of estrogen on diabetic wound healing is mediated through increasing the function of various bone marrow‐derived progenitor cells

  2018cites this paper
• Bu-Shen-Tong-Luo decoction prevents bone loss via inhibition of bone resorption and enhancement of angiogenesis in ovariectomy-induced osteoporosis of rats.

  2018cites this paper
• Reproductive stage and sex steroid hormone levels influence the expression of mesenchymal stromal cell (MSC) markers in the equine endometrium.

  2018cites this paper
• Effects of estradiol on HIF-1α expression and trophoblast differentiation in first trimester villous explant cultures

  2017cites this paper
• Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy

  2017cites this paper
• Inhibitory effects of 17β-estradiol or a resveratrol dimer on hypoxia-inducible factor-1α in genioglossus myoblasts: Involvement of ERα and its downstream p38 MAPK pathways

  2017cites this paper
• Hypoxia increases Nrf2-induced HO-1 expression via the PI3K/Akt pathway.

  2016cites this paper
• The cilia-regulated proteasome and its role in the development of ciliopathies and cancer

  2016cites this paper
• Radiological and immunohistochemical analyses of hyperostosis frontalis interna: multi-level approach to understanding the development of this phenomenon

  2016cites this paper
• 3D‐Microarchitectural patterns of Hyperostosis frontalis interna: a micro‐computed tomography study in aged women

  2016cites this paper
• Stem Cell Death and Survival in the Regenerating Heart

  2016cites this paper
• Stem cell death and survival in heart regeneration and repair

  2016cites this paper
• The effect of progesterone and 17-β estradiol on membrane-bound HLA-G in adipose derived stem cells

  2016cites this paper
• Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model.

  2015cites this paper
• Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen

  2015cites this paper
• Effect of 17β-estradiol on mediators involved in mesenchymal stromal cell trafficking in cell therapy of diabetes.

  2015cites this paper
• A novel synthetic oleanane triterpenoid suppresses adhesion, migration, and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis

  2015cites this paper
• Reactive oxygen species induce MMP12‐dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord‐derived mesenchymal stem cells

  2014cites this paper
• Dimethyloxalylglycine Prevents Bone Loss in Ovariectomized C57BL/6J Mice through Enhanced Angiogenesis and Osteogenesis

  2014cites this paper
• Hypoxia-inducible factor-1: a possible link between inhalational anesthetics and tumor progression?

  2014cites this paper
• Post-stroke estradiol treatment enhances neurogenesis in the subventricular zone of rats after permanent focal cerebral ischemia.

  2013cites this paper
• The role of hypoxia in stem cell potency and differentiation.

  2013cites this paper
• Cell therapy with autologous mesenchymal stem cells-how the disease process impacts clinical considerations.

  2013cites this paper
• The Ciliary Protein Ftm Is Required for Ventricular Wall and Septal Development

  2013cites this paper
• A Computational Model Predicting Disruption of Blood Vessel Development

  2013cites this paper
• Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells

  2013cites this paper
• Rapid actions of plasma membrane estrogen receptors regulate motility of mouse embryonic stem cells through a profilin-1/cofilin-1-directed kinase signaling pathway.

  2012cites this paper
• Induction of inducible nitric oxide synthase by isoflurane post-conditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury.

  2012cites this paper
• Hypoxia-Mediated Regulation of Stem Cell Fate

  2012cites this paper
• Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E2‐induced proliferation of human umbilical cord blood derived mesenchymal stem cells: Involvement of c‐Myc and VEGF expression

  2012cites this paper
• Treatment with a Novel Hypoxia-Inducible Factor Hydroxylase Inhibitor (TRC160334) Ameliorates Ischemic Acute Kidney Injury

  2012cites this paper
• RhoA Activation and Effect of Rho-kinase Inhibitor in the Development of Retinal Neovascularization in a Mouse Model of Oxygen-induced Retinopathy

  2011cites this paper
• Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed?

  2011cites this paper
• Phosphatidylinositol 3 = -kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1 (cid:1) and vascular endothelial growth factor expression

  2011influential citation
• Phosphatidylinositol 3 =-kinase signaling pathway is essential for Rac 1-induced hypoxia-inducible factor-1 and vascular endothelial growth factor expression

  2011influential citation
• Supraphysiological estrogen levels adversely impact proliferation and histone modification in human embryonic stem cells: possible implications for controlled ovarian hyperstimulation assisted pregnancy.

  2011cites this paper
• Intracoronary mesenchymal stem cells promote postischemic myocardial functional recovery, decrease inflammation, and reduce apoptosis via a signal transducer and activator of transcription 3 mechanism.

  2011cites this paper
• Phosphatidylinositol 3'-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression.

  2011cites this paper
• High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF‐β1 expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways

  2010cites this paper
• Mesenchymal Stem Cell Therapy for Treatment of Cardiovascular Disease: Helping People Sooner or Later

  2010cites this paper
• Characteristics of the transcription factor HIF-1α expression in the rat brain during the development of a depressive state and the antidepressive effects of hypoxic preconditioning

  2010cites this paper
• Role of FAK phosphorylation in hypoxia-induced hMSCS migration: involvement of VEGF as well as MAPKS and eNOS pathways.

  2010cites this paper
• Hypoxia inducible factor-1α expression in areca quid chewing-associated oral squamous cell carcinomas.

  2010cites this paper
• Gender Dimorphisms in Progenitor and Stem Cell Function in Cardiovascular Disease

  2010cites this paper
• Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.

  2009cites this paper
• The Role of Hypoxia in Bone Marrow–Derived Mesenchymal Stem Cells: Considerations for Regenerative Medicine Approaches

  2009cites this paper
• A THESIS FOR THE DEGREE OF MASTER Protective effect of netrin-1 on hypoxia-induced mitochondrial apoptosis through HSP27 expression in human umbilical cord blood derived mesenchymal stem cells

  2008cites this paper