Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Regulates Quality of Processed Peptides Presented by MHC Class I Molecules1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.181.9.6275PMID 18941218
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Coping with loss of perfection in the MHC class I peptide repertoire.

  2008cited by this paper
• The Role of Endoplasmic Reticulum-Associated Aminopeptidase 1 in Immunity to Infection and in Cross-Presentation1

  2007cited by this paper
• The final touches make perfect the peptide-MHC class I repertoire.

  2007cited by this paper
• Faculty Opinions recommendation of The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation.

  2007cited by this paper
• In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides

  2007cited by this paper
• Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.

  2006cited by this paper
• ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.

  2006cited by this paper
• In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules

  2006influential reference
• The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules

  2006influential reference
• Mechanisms of MHC class I‐restricted antigen processing and cross‐presentation

  2005cited by this paper
• Induction of Obliterative Airway Disease in Murine Tracheal Allografts by CD8+ CTLs Recognizing a Single Minor Histocompatibility Antigen1

  2005cited by this paper
• All the peptides that fit: the beginning, the middle, and the end of the MHC class I antigen‐processing pathway

  2005cited by this paper
• Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum

  2005cited by this paper
• The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.

  2005cited by this paper
• CHRONIC REJECTION OF MURINE CARDIAC ALLOGRAFTS DISCORDANT AT THE H13 MINOR HISTOCOMPATIBILITY ANTIGEN CORRELATES WITH THE GENERATION OF THE H13‐SPECIFIC CD8+ CYTOTOXIC T CELLS1

  2003cited by this paper
• Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules.

  2002cited by this paper
• The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues

  2002influential reference
• An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

  2002cited by this paper
• ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

  2002influential reference
• How H13 Histocompatibility Peptides Differing by a Single Methyl Group and Lacking Conventional MHC Binding Anchor Motifs Determine Self-Nonself Discrimination1

  2002influential reference
• ER aminopeptidases generate a unique pool of peptides for MHC class I molecules

  2001influential reference
• MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum.

  2001cited by this paper
• Distinguishing Self from Nonself: Immunogenicity of the Murine H47 Locus Is Determined by a Single Amino Acid Substitution in an Unusual Peptide1

  2001cited by this paper
• Degradation of cell proteins and the generation of MHC class I-presented peptides.

  1999cited by this paper
• Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER.

  1999cited by this paper
• The molecular and functional characterization of a dominant minor H antigen, H60.

  1998cited by this paper
• Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex.

  1997influential reference
• An H–YDb epitope is encoded by a novel mouse Y chromosome gene

  1996cited by this paper
• The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

  1995cited by this paper
• LacZ inducible, antigen/MHC-specific T cell hybrids.

  1994cited by this paper
• TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.

  1992influential reference
• Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

  1992cited by this paper
• Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I- restricted cell-mediated lysis

  1991cited by this paper
• Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

  1991cited by this paper
• Cellular peptide composition governed by major histocompatibility complex class I molecules

  1990cited by this paper
• Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes.

  1989cited by this paper
• A procedure for culture of cells from mouse tail biopsies: brief communication.

  1978cited by this paper

• Joint together: The etiology and pathogenesis of ankylosing spondylitis

  2022cites this paper
• Generation of SARS-CoV-2 S1 Spike Glycoprotein Putative Antigenic Epitopes in Vitro by Intracellular Aminopeptidases

  2020cites this paper
• ENDOPLASMIC RETICULUM AMINO PEPTIDASE 1 (ERAP1) IN ANKYLOSING SPONDYLITIS

  2015cites this paper
• HLA-B27-specific Immune Response to Influenza is Critically Dependent on ERAP-1 and on MHC-I Allelic Co-dominant Expression

  2014cites this paper
• HLA-B27, but Not HLA-B7, Immunodominance to Influenza Is ERAP Dependent

  2014cites this paper
• Dependentto Influenza Is ERAP HLA-B27, but Not HLA-B7,

  2014cites this paper
• Fine Substrate Specificity Encode Functionally Distinct Alleles with Haplotypes ERAP1 Naturally Occurring

  2013cites this paper
• This information is current as Fine Substrate Specificity Encode Functionally Distinct Alleles with Haplotypes ERAP 1 Naturally Occurring

  2013cites this paper
• through Attenuation of ERAAP Function Induction of Protective Antitumor Immunity

  2013cites this paper
• Induction of Protective Antitumor Immunity through Attenuation of ERAAP Function

  2013cites this paper
• Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity

  2013cites this paper
• Co‐expression of HLA‐B7 and HLA‐B27 alleles is associated with B7‐restricted immunodominant responses following influenza infection

  2013cites this paper
• The Role of Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) in the Pathogenesis of Ankylosing Spondylitis

  2012cites this paper
• Immunodominance: a pivotal principle in host response to viral infections.

  2012cites this paper
• Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

  2011cites this paper
• Endoplasmic reticulum aminopeptidases: biology and pathogenic potential

  2010cites this paper
• Differential Suppression of Tumor-Specific CD8+ T Cells by Regulatory T Cells

  2010cites this paper
• Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.

  2010cites this paper
• Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

  2010cites this paper
• Regulatory T Cells + CD 8 Differential Suppression of Tumor-Specific

  2010cites this paper
• Endoplasmic Reticulum Aminopeptidase Associated with Antigen Processing Defines the Composition and Structure of MHC Class I Peptide Repertoire in Normal and Virus-Infected Cells

  2010cites this paper
• A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.

  2009cites this paper
• Dependent Immunodominance to Influenza Is Erap Hla-b27, but Not Hla-b7

  year unknowncites this paper
• Virus-infected Cells I Peptide Repertoire in Normal and the Composition and Structure of Mhc Class Associated with Antigen Processing Defines Endoplasmic Reticulum Aminopeptidase

  year unknowncites this paper