"Non-Antibiotics": alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Current Drug Targets

• Publication date

  2006-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2174/138945006777709539PMID 16842219
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria.

  2009cited by this paper
• An International Multicenter Study of Antimicrobial Resistance and Typing of Hospital Staphylococcus aureus Isolates from 21 Laboratories in 19 Countries or States

  2004cited by this paper
• The large-conductance Ca2+-activated K+ channel is essential for innate immunity

  2004cited by this paper
• Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy.

  2004cited by this paper
• Tricyclic antidepressants, QT interval prolongation, and torsade de pointes.

  2004cited by this paper
• Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers.

  2004cited by this paper
• Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.

  2004cited by this paper
• Staphylococcus aureus Bacteremia: Compliance with Standard Treatment, Long-term Outcome and Predictors of Relapse

  2003cited by this paper
• Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.

  2003cited by this paper
• The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus.

  2003cited by this paper
• Utility of Dual Skin Tests to Evaluate Tuberculin Skin Test Reactions of 10 to 14 mm in Healthcare Workers

  2003cited by this paper
• Clinical Concentrations of Thioridazine Kill Intracellular Multidrug-Resistant Mycobacterium tuberculosis

  2003cited by this paper
• Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus.

  2002cited by this paper
• Killing activity of neutrophils is mediated through activation of proteases by K+ flux

  2002cited by this paper
• Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries

  2001cited by this paper
• Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines.

  2001cited by this paper
• Phenothiazines: potential management of Creutzfeldt-Jacob disease and its variants.

  2001cited by this paper
• Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.

  2001cited by this paper
• Low Prevalence of Methicillin-Resistant Strains among Staphylococcus aureus Colonizing Young and Healthy Members of the Community in Portugal

  2001cited by this paper
• Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy.

  2001cited by this paper
• Does size matter? Utility of size of tuberculin reactions for the diagnosis of mycobacterial disease.

  2000cited by this paper
• Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis.

  2000cited by this paper
• Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies.

  2000cited by this paper
• The potential management of resistant infections with non-antibiotics.

  1997cited by this paper
• Plasma levels of the enantiomers of thioridazine, thioridazine 2‐sulfoxide, thioridazine 2‐sulfone, and thioridazine 5‐sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin

  1996cited by this paper
• Inhibition of the respiration of multi-drug resistant clinical isolates of Mycobacterium tuberculosis by thioridazine: potential use for initial therapy of freshly diagnosed tuberculosis.

  1996cited by this paper
• Structure‐antitubercular activity relationship of phenothiazine‐type calmodulin antagonists

  1995cited by this paper
• Synergic effect of chlorpromazine on the activity of some antibiotics.

  1992cited by this paper
• Chlorpromazine: a drug potentially useful for treating mycobacterial infections.

  1992cited by this paper
• Calmodulin-like activity in mycobacteria.

  1991cited by this paper
• Dyes, antipsychotic drugs, and antimicrobial activity. Fragments of a development, with special reference to the influence of Paul Ehrlich.

  1989cited by this paper
• Trimipramine and other antipsychotics inhibit Campylobacter pylori in vitro.

  1989cited by this paper
• [Antimycobacterial properties of phenothiazine type compounds].

  1989cited by this paper
• Membrane stabilizers inhibit potassium efflux from Staphylococcus aureus strain No. U2275.

  1982cited by this paper
• Effect of chlorpromazine on the ultrastructure of Staphylococcus aureus.

  1981cited by this paper
• Experiments to Illustrate The Effect Of Chlorpromazine On The Permeability Of The Bacterial Cell Wall

  1979cited by this paper
• In vitro studies on drug--antibiotic interactions I: analgesics, antipyretics, antimalarials, and tranquilizers.

  1978cited by this paper
• Studies on antituberculotic action of some phenothiazine derivatives in vitro.

  1977cited by this paper
• Penicillin-binding proteins and cell shape in E. coli

  1975cited by this paper
• [Elimination of penicillin resistance determinants in Staphylococcus aureus with acridines and phenothiazines].

  1973cited by this paper

• Inhibitors of Type II NADH Dehydrogenase Enzyme: A Review.

  2025cites this paper
• Cinacalcet exhibits rapid bactericidal and efficient anti-biofilm activities against multidrug-resistant Gram-positive pathogens.

  2023cites this paper
• Antibacterial activity and time kill kinetics of Amlodipine, Thioridazine and Promethazine against pathogenic clinical bacterial isolates

  2021cites this paper
• Polyol mediated synthesis of hexagonal manganese cobaltate nanoparticles for voltammetric determination of thioridazine

  2021cites this paper
• Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review.

  2021cites this paper
• Metformin as a Potential Adjuvant Antimicrobial Agent Against Multidrug Resistant Bacteria

  2021cites this paper
• A Novel Derivative of Thioridazine Shows Low Toxicity and Efficient Activity against Gram-Positive Pathogens

  2020cites this paper
• Dos distúrbios psiquiátricos à antibioticoterapia: reposicionamento da clorpromazina como agente antibacteriano

  2019cites this paper
• Preparation, characterization, and antibacterial activity of diclofenac-loaded chitosan nanoparticles

  2018cites this paper
• Chapter 9 New Approaches for Chagas ’ Disease Chemotherapy

  2018cites this paper
• Repurposing psychiatric drugs as anti-cancer agents.

  2018cites this paper
• The challenge of drug resistant tuberculosis

  2018cites this paper
• A Study on Antibacterial Activity of Daehwanggeonwoo-san(Dahwangqianniu-san) Ethanol Extract against Methicillin-Resistant Staphylococcus Aureus

  2018cites this paper
• New Approaches for Chagas’ Disease Chemotherapy

  2018cites this paper
• Dibasic Derivatives of Phenylcarbamic Acid against Mycobacterial Strains: Old Drugs and New Tricks?

  2018cites this paper
• Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action

  2017cites this paper
• Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis.

  2017cites this paper
• Treatment with high-dose antidepressants severely exacerbates the pathological outcome of experimental Escherichia coli infections in poultry

  2017cites this paper
• New Antimicrobial Approaches: Reuse of Old Drugs.

  2016cites this paper
• Modulation of Antibiotic Efficacy against Klebsiella pneumoniae byAntihistaminic Drugs

  2016cites this paper
• The inhibition effect of Chlorpromazine against the β-lactam resistance of MRSA.

  2016cites this paper
• Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease.

  2015cites this paper
• Abnormal immune system development and function in schizophrenia helps reconcile diverse findings and suggests new treatment and prevention strategies.

  2015cites this paper
• Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae.

  2014cites this paper
• Thioridazine for treatment of tuberculosis: promises and pitfalls.

  2014cites this paper
• Energetics of pathogenic bacteria and opportunities for drug development.

  2014cites this paper
• Antituberculosis Drug Research: A Critical Overview

  2013cites this paper
• Is repositioning of drugs a viable alternative in the treatment of tuberculosis?

  2013cites this paper
• Reuse of Old, Existing, Marketed Non-antibiotic Drugs as Antimicrobial Agents: a New Emerging Therapeutic Approach

  2013cites this paper
• Exposure of Chlorpromazine to 266 nm Laser Beam Generates New Species with Antibacterial Properties: Contributions to Development of a New Process for Drug Discovery

  2013cites this paper
• Correction: Exposure of Chlorpromazine to 266 nm Laser Beam Generates New Species with Antibacterial Properties: Contributions to Development of a New Process for Drug Discovery

  2013cites this paper
• Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs

  2012cites this paper
• The added effect of thioridazine in the treatment of drug-resistant tuberculosis.

  2012cites this paper
• Evaluation of in vivo and in vitro Antimicrobial activities of a selective serotonin reuptake inhibitor

  2012cites this paper
• Role of the Mmr Efflux Pump in Drug Resistance in Mycobacterium tuberculosis

  2012cites this paper
• Is adjuvant therapy a potential road for fighting Mycobacterium tuberculosis resistance?

  2012cites this paper
• A Cheap and Effective Anti-Mdr/Xdr/Tdr Tb Drug is Already Available

  2012cites this paper
• 1 Role of the Mmr efflux pump in drug resistance in M. tuberculosis

  2012cites this paper
• Thioridazine: alternative and potentially effective therapy of the XDRTB patient

  2011cites this paper
• A unifying hypothesis of schizophrenia: abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction.

  2010cites this paper
• Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB.

  2010cites this paper
• Molecular tools for rapid identification and novel effective therapy against MDRTB/XDRTB infections

  2010cites this paper
• Targeting human macrophages for enhanced killing of intracellular XDR-TB and MDR-TB.

  2009cites this paper
• Antibacterial Activity of Artificial Phenothiazines and Isoflavones from Plants

  2008cites this paper
• Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps.

  2008cites this paper
• The TB laboratory of the future: macrophage-based selection of XDR-TB therapeutics.

  2008influential citation
• Reversal of methicillin resistance in Staphylococcus aureus by thioridazine.

  2008cites this paper
• In vitro efficacy of diclofenac against Listeria monocytogenes

  2008cites this paper
• Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis.

  2008cites this paper
• Inhibitors of Ca2+ and K+ transport enhance intracellular killing of M. tuberculosis by non-killing macrophages.

  2008cites this paper
• Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities.

  2008cites this paper
• In vitro and ex vivo activity of thioridazine derivatives against Mycobacterium tuberculosis.

  2007cites this paper
• Reversal of resistance in microorganisms by help of non-antibiotics.

  2007cites this paper
• The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis.

  2007cites this paper
• Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice.

  2007cites this paper
• Review. Comparison of multidrug resistant efflux pumps of cancer and bacterial cells with respect to the same inhibitory agents.

  2007cites this paper
• Management of multidrug‐resistant tuberculosis: Update 2007

  2007cites this paper
• Thioridazine: resurrection as an antimicrobial agent?

  2007cites this paper
• Send Orders of Reprints at Reprints@benthamscience.net Multidrug Efflux Pumps in Staphylococcus Aureus: an Update

  year unknowncites this paper