Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Advances in Experimental Medicine and Biology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1007/978-3-319-63245-2_13PMID 29047089PMCID PMC5766272
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thiol-Based Redox Modulation of Soluble Guanylyl Cyclase, the Nitric Oxide Receptor

  2017cited by this paper
• Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives

  2017cited by this paper
• Pulmonary Arteries Show Differences in the Effects of Angiotensin II Stimulation of Mitochondrial Superoxide on Regulation of Heme Biosynthesis and Soluble Guanylate Cyclase Expression

  2016cited by this paper
• Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II.

  2016cited by this paper
• Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.

  2016cited by this paper
• Soluble Guanylate Cyclase: A New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension

  2015cited by this paper
• Aminolevulinic Acid Treatment of Pulmonary Arteries Attenuates Endothelin‐1 and Angiotensin II Elicited Increases in Mitochondrial, but not Extra‐Mitochondrial Superoxide

  2015cited by this paper
• Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension.

  2015cited by this paper
• Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide.

  2014cited by this paper
• Structural insights into the role of iron–histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins

  2014cited by this paper
• Dehydroepiandrosterone promotes pulmonary artery relaxation by NADPH oxidation‐elicited subunit dimerization of protein kinase G1α (1175.9)

  2014cited by this paper
• Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1α.

  2013cited by this paper
• Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.

  2012cited by this paper
• Serum from Calorie-Restricted Rats Activates Vascular Cell eNOS through Enhanced Insulin Signaling Mediated by Adiponectin

  2012cited by this paper
• Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure.

  2012cited by this paper
• Glc-6-PD and PKG contribute to hypoxia-induced decrease in smooth muscle cell contractile phenotype proteins in pulmonary artery.

  2012cited by this paper
• Dehydroepiandrosterone (DHEA) improves pulmonary hypertension in chronic obstructive pulmonary disease (COPD): a pilot study.

  2012cited by this paper
• Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation*

  2011cited by this paper
• Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia.

  2011cited by this paper
• Assessment of oxidative stress in patients with sickle cell disease: The glutathione system and the oxidant-antioxidant status.

  2011cited by this paper
• Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.

  2011cited by this paper
• Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury

  2011cited by this paper
• Redox regulation of guanylate cyclase and protein kinase G in vascular responses to hypoxia.

  2010cited by this paper
• Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn.

  2010cited by this paper
• Activation of Glucose-6-phosphate Dehydrogenase Promotes Acute Hypoxic Pulmonary Artery Contraction*

  2010cited by this paper
• Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteosomal degradation

  2009cited by this paper
• Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy

  2009cited by this paper
• Reactive oxygen species and the control of vascular function.

  2009cited by this paper
• The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

  2008cited by this paper
• Fibroblast Growth Factor-2 Expression Is Altered in Lambs With Increased Pulmonary Blood Flow and Pulmonary Hypertension

  2007cited by this paper
• NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts.

  2007cited by this paper
• Cysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation

  2007cited by this paper
• Nitric Oxide in the Pulmonary Vasculature

  2007influential reference
• The regulation and pharmacology of endothelial nitric oxide synthase.

  2006cited by this paper
• Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.

  2006cited by this paper
• Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep.

  2005cited by this paper
• Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus.

  2005cited by this paper
• Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH.

  2005cited by this paper
• Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries.

  2005cited by this paper
• Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor.

  2004cited by this paper
• Alterations in TGF-β1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension

  2003cited by this paper
• Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension.

  2003cited by this paper
• Alterations in TGF-beta1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension.

  2003cited by this paper
• Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: The simple NO-binding model is incorrect

  2002cited by this paper
• Decreased Endothelial Nitric-oxide Synthase (eNOS) Activity Resulting from Abnormal Interaction between eNOS and Its Regulatory Proteins in Hypoxia-induced Pulmonary Hypertension*

  2002cited by this paper
• Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells.

  2002cited by this paper
• Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling

  2002cited by this paper
• Molecular Regulation of the Endothelin-1 Gene by Hypoxia

  2001cited by this paper
• Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium.

  2001cited by this paper
• Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance

  2001cited by this paper
• Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferation.

  2000cited by this paper
• Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: species variation.

  1999cited by this paper
• Role of Nitric Oxide in Regulating Neonatal Porcine Pulmonary Artery Smooth Muscle Cell Proliferation

  1999cited by this paper
• Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.

  1998cited by this paper
• ANG II stimulates endothelial nitric oxide synthase expression in bovine pulmonary artery endothelium.

  1997cited by this paper
• Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.

  1996cited by this paper
• Regulation of pulmonary vascular tone in the perinatal period.

  1995cited by this paper
• Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells.

  1995cited by this paper
• Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

  1993cited by this paper
• Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.

  1993cited by this paper
• Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

  1989cited by this paper
• Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

  1987cited by this paper
• Cyclic GMP synthesis and function.

  1987cited by this paper
• Association between cyclic GMP accumulation and acetylcholine-elicited relaxation of bovine intrapulmonary artery.

  1984cited by this paper
• Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

  1981cited by this paper
• Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

  1978cited by this paper
• Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds.

  1976cited by this paper
• highlighted topics Signal Transduction in Smooth Muscle Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression

  year unknowncited by this paper

• Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis

  2020cites this paper
• Pulmonary Embolism in Patients with COVID-19: A Systematic review and Meta-analysis

  2020cites this paper
• Soluble Guanylate Cyclase Stimulators and Activators.

  2019cites this paper
• Nitrogen Monoxide (Nitric Oxide): Bioinorganic Chemistry

  2019cites this paper
• Biochemistry, Cyclic GMP

  2019cites this paper
• Estrogen Contributions to Microvascular Dysfunction Evolving to Heart Failure With Preserved Ejection Fraction

  2019cites this paper
• Metabolism and Redox in Pulmonary Vascular Physiology and Pathophysiology

  2019cites this paper
• Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase

  2018cites this paper
• The A-Site In The Pkg Iα Regulatory Domain Controls Both Cgmp- And Oxidative-Dependent Activation

  2018cites this paper
• Pulmonary vascular pathophysiology.

  2018cites this paper