Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Pharmacy and Science

• Publication date

  2015-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/jps.24637PMID 26372815PMCID PMC4706797
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells

  2014cited by this paper
• Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation

  2014cited by this paper
• Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer.

  2014cited by this paper
• Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: preparation, characterization and antitumor activity.

  2014cited by this paper
• Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid

  2014cited by this paper
• Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

  2014cited by this paper
• Medium chain triglyceride (MCT) rich, paclitaxel loaded self nanoemulsifying preconcentrate (PSNP): a safe and efficacious alternative to Taxol.

  2013cited by this paper
• P‐glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

  2013cited by this paper
• Taxanes: old drugs, new oral formulations.

  2013cited by this paper
• Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats.

  2012cited by this paper
• Triple-negative breast cancer: epidemiological considerations and recommendations.

  2012cited by this paper
• Selective killing of cancer cells with a small molecule targeting stress response to ROS

  2011cited by this paper
• Attenuation of Intestinal Absorption by Major Efflux Transporters: Quantitative Tools and Strategies Using a Caco-2 Model

  2011cited by this paper
• Triple-negative breast cancer: an unmet medical need.

  2011cited by this paper
• Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer.

  2011cited by this paper
• Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

  2011cited by this paper
• Enhanced Anticancer Activity of Gemcitabine in Combination with Noscapine via Antiangiogenic and Apoptotic Pathway against Non-Small Cell Lung Cancer

  2011cited by this paper
• Antitumor Activity of Noscapine in Combination with Doxorubicin in Triple Negative Breast Cancer

  2011cited by this paper
• Effect of Regular Organic Solvents on cytochrome P450 Mediated Metabolic Activities in Rat Liver Microsomes

  2010cited by this paper
• Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P‐glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats

  2010cited by this paper
• Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.

  2010cited by this paper
• Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1*

  2010cited by this paper
• MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells

  2010cited by this paper
• Effect of Regular Organic Solvents on Cytochrome P450-Mediated Metabolic Activities in Rat Liver Microsomes

  2010cited by this paper
• Current treatment options in triple negative breast cancer.

  2010cited by this paper
• Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer.

  2010cited by this paper
• Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer.

  2009cited by this paper
• Alternative drug formulations of docetaxel: a review.

  2007cited by this paper
• In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

  2007cited by this paper
• 15-Deoxy-Delta12,14-prostaglandin J2 enhances docetaxel anti-tumor activity against A549 and H460 non-small-cell lung cancer cell lines and xenograft tumors.

  2007cited by this paper
• Ganciclovir augments the lytic induction and apoptosis induced by chemotherapeutic agents in an Epstein–Barr virus-infected gastric carcinoma cell line

  2007cited by this paper
• Altered pharmacokinetics of paclitaxel by the concomitant use of morin in rats.

  2006cited by this paper
• Inhalation Delivery and Anti-tumor Activity of Celecoxib in Human Orthotopic Non-Small Cell Lung Cancer Xenograft Model

  2006cited by this paper
• Role of P-Glycoprotein in Pharmacokinetics

  2003cited by this paper
• Evaluation of An Aerosolized Selective COX-2 Inhibitor as a Potentiator of Doxorubicin in a Non-Small-Cell Lung Cancer Cell Line

  2003cited by this paper
• Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.

  2001cited by this paper
• Targeting of methotrexate-containing liposomes with a monoclonal antibody against human renal cancer.

  1989cited by this paper

• Natural bioactive molecules and chemotherapeutics synergism for enhanced cancer therapy.

  2026cites this paper
• A patent review of CYP3A4 inhibitors (2018 – present)

  2025cites this paper
• Antitumor activity of celecoxib with docetaxel on human triple-negative breast cancer cells

  2025cites this paper
• Piperlongumine and its derivatives against cancer: A recent update and future prospective

  2024cites this paper
• Green Extraction of Plant Materials Using Supercritical CO2: Insights into Methods, Analysis, and Bioactivity

  2024cites this paper
• Piperlongumine: the amazing amide alkaloid from Piper in the treatment of breast cancer

  2023influential citation
• Development of core–shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer

  2023cites this paper
• A Pharmacological Insight of Piperlongumine, Bioactive Validating Its Therapeutic Efficacy as a Drug to Treat Inflammatory Diseases

  2023cites this paper
• Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: involvement of glucose import, ROS, NF-κB and lncRNAs

  2022cites this paper
• Development of a safe Pediatric liquisolid Self-Nanoemulsifying System of Triclabendazole for the treatment of fascioliasis.

  2022cites this paper
• The Potential of Plant-Derived Extracts and Compounds to Augment Anticancer Effects of Chemotherapeutic Drugs

  2022cites this paper
• Synergistic effects of natural compounds and conventional chemotherapeutic agents: recent insights for the development of cancer treatment strategies

  2022cites this paper
• Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway

  2022influential citation
• Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells.

  2022cites this paper
• Role of In Vitro Models for Development of Ophthalmic Delivery Systems.

  2021cites this paper
• Cannabidiol Inhibits In Vitro Human Liver Microsomal Metabolism of Remdesivir

  2021cites this paper
• Advances of Exosomal miRNAs in Breast Cancer Progression and Diagnosis

  2021cites this paper
• Stromal disruption facilitating invasion of a 'nano-arsenal' into the solid tumor.

  2021cites this paper
• The promising potential of piperlongumine as an emerging therapeutics for cancer

  2021cites this paper
• Galactose-decorated liver tumor-specific nanoliposomes incorporating selective BRD4-targeted PROTAC for hepatocellular carcinoma therapy

  2021cites this paper
• Role of Exosomes for Delivery of Chemotherapeutic Drugs.

  2021cites this paper
• Cannabidiol Loaded Extracellular Vesicles Sensitize Triple-Negative Breast Cancer to Doxorubicin in both in-vitro and in vivo Models Running Title: Formulation and anti-cancer potential of CBD loaded hUCMSC-derived Extracellular Vesicles in TNBC.

  2021cites this paper
• Drug metabolism and pharmacokinetic diversity of Taxus medicinal compounds

  2021cites this paper
• Oncology Therapeutics Targeting the Metabolism of Amino Acids

  2020cites this paper
• Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent.

  2020cites this paper
• Nanoformulation of PROteolysis TArgeting Chimera targeting 'undruggable' c-Myc for the treatment of pancreatic cancer.

  2020cites this paper
• Sustained release dosage form of noscapine HCl using hot melt extrusion (HME) technique: formulation and pharmacokinetics

  2020cites this paper
• The Natural Alkaloid Piperlongumine Inhibits Metastatic Activity and Epithelial-to-Mesenchymal Transition of Triple-Negative Mammary Carcinoma Cells

  2020cites this paper
• Role of Nano-lipid Formulation of CARP-1 mimetic, CFM-4.17 to Improve Systemic Exposure and Response in Osimertinib Resistant Non-Small Cell Lung Cancer.

  2020cites this paper
• Harmine and Piperlongumine Revert TRIB2-Mediated Drug Resistance

  2020cites this paper
• Piperlongumine Inhibits Akt Phosphorylation to Reverse Resistance to Cisplatin in Human Non-Small Cell Lung Cancer Cells via ROS Regulation

  2019cites this paper
• Design of diffusion‐controlled drug delivery devices for controlled release of Paclitaxel

  2019cites this paper
• Erlotinib-Valproic Acid Liquisolid Formulation: Evaluating Oral Bioavailability and Cytotoxicity in Erlotinib-Resistant Non-small Cell Lung Cancer Cells

  2019cites this paper
• Synergistic anticancer activity of doxorubicin and piperlongumine on DU-145 prostate cancer cells - The involvement of carbonyl reductase 1 inhibition.

  2019cites this paper
• BRD4 PROTAC as a novel therapeutic approach for the treatment of vemurafenib resistant melanoma: Preformulation studies, formulation development and in vitro evaluation.

  2019cites this paper
• A Systematic Review of Drug Metabolism Studies of Plants With Anticancer Properties: Approaches Applied and Limitations

  2019cites this paper
• Development of Arginine Anchored Nano-Globule with Retrograde Trafficking Inhibitor (Retro-2) for the Treatment of Enterohemorrhagic Escherichia coli outbreak.

  2019cites this paper
• Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

  2019cites this paper
• Nanoparticles from Gantrez® AN-poly(ethylene glycol) conjugates as carriers for oral delivery of docetaxel.

  2019cites this paper
• Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes.

  2018cites this paper
• Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

  2018cites this paper
• First report on the pharmacokinetic profile of nimbolide, a novel anticancer agent in oral and intravenous administrated rats by LC/MS method.

  2018cites this paper
• Piperlongumine and p53-Reactivator APR-246 Selectively Induce Cell Death in HNSCC by Targeting GSTP1

  2018cites this paper
• An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

  2018cites this paper
• Development of Hot Melt Extruded Solid Dispersion of Tamoxifen Citrate and Resveratrol for Synergistic Effects on Breast Cancer Cells

  2018cites this paper
• “Yogvahi (Bioenhancer)”: An Ayurvedic Concept Used in Modern Medicines

  2018cites this paper
• Cholecalciferol-PEG Conjugate Based Nanomicelles of Doxorubicin for Treatment of Triple-Negative Breast Cancer

  2017cites this paper
• Enhanced oral bioavailability of docetaxel in rats combined with myricetin: In situ and in vivo evidences

  2017cites this paper
• Preformulation and Topical Penetration Studies

  2017cites this paper
• Liposomes co-Loaded with 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3 (PFKFB3) shRNA Plasmid and Docetaxel for the Treatment of non-small Cell Lung Cancer

  2017cites this paper
• Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC).

  2017cites this paper
• Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer

  2017cites this paper
• Noscapine chemosensitization enhances docetaxel anticancer activity and nanocarrier uptake in triple negative breast cancer.

  2016cites this paper
• Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

  2016cites this paper
• Tumor stromal disrupting agent enhances the anticancer efficacy of docetaxel loaded PEGylated liposomes in lung cancer.

  2016cites this paper
• Multifunctional Mixed Micelles for Efficient Docetaxol Delivery for Cancer Therapy.

  2016cites this paper
• Putative Status of Actively Operative Performance Attributes as Determinants of Minimal Platform Oncogenesis in C-Myc Amplification

  2016cites this paper
• Preformulation Studies on Piperlongumine

  2016cites this paper
• Combination Approach of YSA Peptide Anchored Docetaxel Stealth Liposomes with Oral Antifibrotic Agent for the Treatment of Lung Cancer.

  2016cites this paper
• Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine*

  2016cites this paper