Optimizing Insulin Absorption and Insulin Injection Technique in Older Adults

The objective of our study was to determine the impact of anatomic site and injection technique on insulin absorption in the elderly. Twenty elderly insulin-naive subjects (age 80 ± 1 years; sex 7 female, 13 male; BMI 29 ± 1 kg/m2; diabetes duration 11 ± 2 years; A1C 7.1 ± 0.2% [54 ± 2 mmol/mol]) were studied (clinicaltrials.gov NCT01213901). All subjects provided informed written consent (Declaration of Helsinki). Subjects underwent three 360-min euglycemic glucose clamp studies in random order. In each, 0.1 units/kg of insulin lispro (Humalog; Eli Lilly, Indianapolis, IN) was administered subcutaneously using a 5-mm needle. The investigator conducting the clamp and the technician collecting samples were blind to treatment. In two studies, insulin was given 6.0 cm from the umbilicus using either a skin lift or no skin lift …

• Publication year

  2013

• Venue

  Diabetes Care

• Publication date

  2013-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2337/dc14-0086PMID 24855165
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Injection Site Effects on the Pharmacokinetics and Glucodynamics of Insulin Lispro and Regular Insulin

  1996cited by this paper
• Effects of the Anatomical Region Used for Insulin Injections on Glycemia in Type I Diabetes Subjects

  1993cited by this paper
• Relationship Between Absorption of Radiolabeled Soluble Insulin, Subcutaneous Blood Flow, and Anthropometry

  1992cited by this paper
• Absorption Kinetics and Biologic Effects of Subcutaneously Injected Insulin Preparations

  1982cited by this paper
• Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise: Blood glucose, plasma insulin, growth hormone, adrenaline and noradrenaline levels

  1982cited by this paper
• Alterations in Insulin Absorption and in Blood Glucose Control associated with Varying Insulin Injection Sites in Diabetic Patients

  1981cited by this paper
• Alterations in Insulin Absorption and in Blood Glucose Control Associated with Varying Insulin Injection Sites in Diabetic Patients

  1980cited by this paper

• Le diabète chez les personnes âgées Comité d’experts des Lignes directrices de pratique clinique de Diabète Canada

  2019cites this paper
• Diabetes in Older People.

  2018cites this paper
• In-Hospital Administration of Insulin by Nurses in Northern Greece: An Observational Study

  2017cites this paper