Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Digestive Diseases and Sciences

• Publication date

  2018-01-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s10620-018-4943-5PMID 29383608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gene expression analysis of biopsy samples reveals critical limitations of transcriptome‐based molecular classifications of hepatocellular carcinoma

  2016cited by this paper
• Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

  2016cited by this paper
• Tumor Heterogeneity in Hepatocellular Carcinoma: Facing the Challenges

  2016cited by this paper
• AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways

  2016cited by this paper
• Prognostic significance of AKR1B10 gene expression in hepatocellular carcinoma and surrounding non-tumorous liver tissue.

  2016cited by this paper
• Metabolomics reveals that aldose reductase activity due to AKR1B10 is upregulated in hepatitis C virus infection

  2015cited by this paper
• Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats.

  2014cited by this paper
• Laser capture microdissection after γ-glutamyl transferase histochemistry: an optimization for gene expression analysis.

  2014cited by this paper
• Intratumor Heterogeneity in Hepatocellular Carcinoma

  2014cited by this paper
• High Expression of Aldo-Keto Reductase 1B10 Is an Independent Predictor of Favorable Prognosis in Patients with Hepatocellular Carcinoma

  2014cited by this paper
• Aldoketoreductase family 1B10 (AKR1B10) as a biomarker to distinguish hepatocellular carcinoma from benign liver lesions.

  2014cited by this paper
• Identification of proteomic signatures associated with lung cancer and COPD.

  2013cited by this paper
• Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines

  2013cited by this paper
• The fibrotic microenvironment as a heterogeneity facet of hepatocellular carcinoma

  2013cited by this paper
• Quantitative Evaluation of Aldo–keto Reductase Expression in Hepatocellular Carcinoma (HCC) Cell Lines

  2013cited by this paper
• Activation of Nrf2 is required for up-regulation of the π class of glutathione S-transferase in rat primary hepatocytes with L-methionine starvation.

  2012cited by this paper
• Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

  2012cited by this paper
• Gel-based proteomics of liver cancer progression in rat.

  2011cited by this paper
• Molecular Pathology of Hepatic Neoplasms: Classification and Clinical Significance

  2011cited by this paper
• Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.

  2011cited by this paper
• Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

  2011cited by this paper
• Regulation of aldo-keto reductase AKR1B10 gene expression: involvement of transcription factor Nrf2.

  2011cited by this paper
• Aldo‐keto reductase‐7A protects liver cells and tissues from acetaminophen‐induced oxidative stress and hepatotoxicity

  2011cited by this paper
• AKR1B10 expression is associated with less aggressive hepatocellular carcinoma: a clinicopathological study of 168 cases

  2011cited by this paper
• Molecular events in hepatic preneoplasia: a review.

  2010cited by this paper
• Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid.

  2010cited by this paper
• Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours.

  2010cited by this paper
• Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10

  2010cited by this paper
• Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

  2010cited by this paper
• Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor.

  2010cited by this paper
• Steroid Hormone Transforming Aldo‐Keto Reductases and Cancer

  2009cited by this paper
• Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.

  2009cited by this paper
• Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.

  2009cited by this paper
• The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*

  2009cited by this paper
• Aldo-keto reductase family 1 member B1 inhibitors: old drugs with new perspectives.

  2009cited by this paper
• RSAT: regulatory sequence analysis tools

  2008cited by this paper
• Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum

  2008cited by this paper
• gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.

  2006cited by this paper
• γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells

  2006cited by this paper
• Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis

  2005cited by this paper
• Mechanisms of cancer drug resistance.

  2002cited by this paper
• A new nomenclature for the aldo-keto reductase superfamily.

  1997cited by this paper
• Follow-up of GST-P during hepatocarcinogenesis with DEN-2AAF in F344 rats.

  1995cited by this paper
• Interaction of cadmium with actin microfilaments in vitro.

  1989cited by this paper
• New principle for the analysis of chemical carcinogenesis

  1976cited by this paper

• Insights into tumor-derived exosome inhibition in cancer therapy.

  2025cites this paper
• AKR1B1 is Required for Maintaining Acute Leukemia Cell Survival by Epigenetic Silencing of Tumor Suppressor Genes

  2024cites this paper
• Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs

  2024cites this paper
• Serum Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) as a Potential Biomarker for Diagnosis of Hepatocellular Carcinoma

  2024cites this paper
• Assessment of Serum Aldo-Keto Reductase Family 1 Member B10 for Early Diagnosis of Hepatocellular Carcinoma Patients in Suez Canal University Hospital, Egypt ‎

  2023cites this paper
• Analysis of differentially expressed genes in bile acid-treated liver cancer cells

  2023cites this paper
• Development and validation of an individualized gene expression-based signature to predict overall survival of patients with high-grade serous ovarian carcinoma

  2023cites this paper
• Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5

  2023cites this paper
• Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway

  2023cites this paper
• Analysis of Differential Expression Profiles of Liver Cancer Cell Proteins After Treatment with Bile Acid

  2022cites this paper
• AKR1B1 as a Prognostic Biomarker of High-Grade Serous Ovarian Cancer

  2022cites this paper
• Clinical and Experimental Evaluation of Diagnostic Significance of Alpha-Fetoprotein and Osteopontin at the Early Stage of Hepatocellular Cancer

  2021cites this paper
• Enrichment of progenitor cells by 2‐acetylaminofluorene accelerates liver carcinogenesis induced by diethylnitrosamine in vivo

  2021cites this paper
• AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas

  2021cites this paper
• Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway

  2021cites this paper
• Retinoic Acids in the Treatment of Most Lethal Solid Cancers

  2020influential citation
• Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers.

  2020cites this paper
• The AKR1B1 inhibitor epalrestat suppresses the progression of cervical cancer

  2020cites this paper
• Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential

  2020cites this paper
• Use of AKR1C1 and TKTL1 in the Diagnosis of Low-grade Squamous Intraepithelial Lesions from Mexican Women

  2020cites this paper
• Development of aldose reductase inhibitors for the treatment of inflammatory disorders and cancer: current drug design strategies and future directions.

  2020cites this paper
• Identification of Time-Invariant Biomarkers for Non-Genotoxic Hepatocarcinogen Assessment

  2020cites this paper
• Biomarkers in Diagnosis and Prediction of Hepatocellular Carcinoma Recurrence (Review)

  2019cites this paper
• Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.

  2019cites this paper
• A Large‐Scale Multicenter Study Validates Aldo‐Keto Reductase Family 1 Member B10 as a Prevalent Serum Marker for Detection of Hepatocellular Carcinoma

  2019cites this paper
• Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma

  2019cites this paper
• MicroRNAs in Animal Models of HCC

  2019cites this paper
• Contribution of Aldose Reductase-Mediated Oxidative Stress Signaling in Inflammatory Lung Diseases

  2019cites this paper
• β2-AR regulates the expression of AKR1B1 in human pancreatic cancer cells and promotes their proliferation via the ERK1/2 pathway

  2018cites this paper