signaling pathway induces magnesium release mediated by mitoKATP channel opening in rat hippocampal neurons

Intracellular Mg concentration (1⁄2Mg i) and NO regulate cell survival and death. To reveal the involvement of NO in intracellular Mg regulation, we visualized intracellular Mg using the fluorescent Mg indicator KMG-104-AM in rat hippocampal neurons. Pharmacological experiments using SNAP, 8-Br-cGMP, diazoxide and several inhibitors revealed that the NO/cGMP/Protein kinsase G (PKG) signaling pathway triggers an increase in 1⁄2Mg i, and that Mg 2+ mobilization is due to Mg release from mitochondria induced by mitoKATP channel opening. In addition, Mg release is potentiated by the positive feedback loop including mitoKATP channel opening, mitochondrial depolarization and PKC activation. 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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