Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

• Publication date

  2005-11-05

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.JCHROMB.2005.09.007PMID 16183337
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Automated on-line SPE LC-MS/MS method to quantitate 6beta-hydroxycortisol and cortisol in human urine: use of the 6beta-hydroxycortisol to cortisol ratio as an indicator of CYP3A4 activity.

  2005cited by this paper
• Simultaneous determination of 6beta-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6beta-hydroxylation clearance.

  2004cited by this paper
• Simultaneous determination of 6β-hydroxycortisol and cortisol in human urine by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity determined by the cortisol 6β-hydroxylation clearance

  2004cited by this paper
• Simple and sensitive high-performance liquid chromatography method for simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol in routine practice. For CYP 3A4 activity evaluation in basal conditions and after grapefruit juice intake.

  2003cited by this paper
• Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals.

  2003cited by this paper
• Urinary 6β-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals

  2003cited by this paper
• Evidence for the validity of cortisol 6 beta-hydroxylation clearance as a new index for in vivo cytochrome P450 3A phenotyping in humans.

  2003cited by this paper
• Plasma 6beta-hydroxycortisol measurements for assessing altered hepatic drug metabolizing enzyme activity.

  2003cited by this paper
• Simple and sensitive high-performance liquid chromatography method for simultaneous determination of urinary free cortisol and 6β-hydroxycortisol in routine practice For CYP 3A4 activity evaluation in basal conditions and after grapefruit juice intake

  2003cited by this paper
• No correlations between the urinary ratio of 6β-hydroxycortisol to free cortisol and pharmacokinetics of alprazolam

  2001cited by this paper
• Circadian variation of the urinary 6β-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity

  2000cited by this paper
• Simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry and its application for estimating hepatic CYP3A induction.

  2000cited by this paper
• Specific determination of urinary 6beta-hydroxycortisol and cortisol by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.

  2000cited by this paper
• Simultaneous determination of endogenous and 13C-labelled cortisols and cortisones in human plasma by stable isotope dilution mass spectrometry.

  2000cited by this paper
• Interference of 6β-Hydroxycortisol in the Quantitation of Urinary Free Cortisol by Immunoassay and Its Elimination by Solid Phase Extraction

  1998cited by this paper
• Interference of 6 beta-hydroxycortisol in the quantitation of urinary free cortisol by immunoassay and its elimination by solid phase extraction.

  1998cited by this paper
• Development of a monoclonal antibody to 6 beta-hydroxycortisol and its application in an enzyme-linked immunosorbent assay (ELISA) for 6 beta-hydroxycortisol in urine.

  1997cited by this paper
• Development of a monoclonal antibody to 6β-hydroxycortisol and its application in an enzyme-linked immunosorbent assay (ELISA) for 6β-hydroxycortisol in urine

  1997cited by this paper
• Simultaneous high-performance liquid chromatographic determination of 6 beta-hydroxycortisol and cortisol in urine with fluorescence detection and its application for estimating hepatic drug-metabolizing enzyme induction.

  1994cited by this paper
• Simultaneous determination of urinary free cortisol and 6 beta-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity.

  1994cited by this paper
• The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

  1989cited by this paper
• Identification of a polymorphically expressed member of the human cytochrome P-450III family.

  1989cited by this paper
• 6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine.

  1961cited by this paper

• Simultaneous Determination of Cortisol and 6β-Hydroxycortisol in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry.

  2022cites this paper
• A background subtraction approach for determination of endogenous cortisol and 6β-hydroxycortisol in urine by UPLC-MS/MS with application in a within-day variability study in HIV-infected pregnant women.

  2020cites this paper
• Glucocorticoids dosing in obese subjects: A systematic review.

  2019cites this paper
• Sensitive and simultaneous quantitation of 6β-hydroxycortisol and cortisol in human plasma by LC-MS/MS coupled with stable isotope dilution method.

  2018cites this paper
• Endocrine stress response in Oreochromis sp. from exposure to waterborne cadmium: the plasma cortisol analysis

  2017influential citation
• 肺Mycobacterium avium complex症治療薬の薬物相互作用と適正使用

  2016cites this paper
• Development and Validation of Sensitive Liquid Chromatography / Tandem Mass Spectrometry Method for Rapid Quantification o f U rinary Cortisol and 6 β-Hydroxycortisol and Evaluation of Metabolic Ratio as Biomarker of CYP 3 A Activity in Clinical Trial

  2015cites this paper
• Quantification of natural and synthetic glucocorticoids in calf urine following different growth-promoting prednisolone treatments.

  2015cites this paper
• Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes

  2015cites this paper
• Simultaneous determination of cortisol, cortisone, 6β-hydroxycortisol and 6β-hydroxycortisone by HPLC.

  2015cites this paper
• Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism.

  2015cites this paper
• Chemometric Evaluation of Urinary Steroid Hormone Levels as Potential Biomarkers of Neuroendocrine Tumors

  2013cites this paper
• Optimization of a Pre-MEKC Separation SPE Procedure for Steroid Molecules in Human Urine Samples

  2013cites this paper
• Quantitative analysis of cortisol and 6β-hydroxycortisol in urine by fully automated SPE and ultra-performance LC coupled with electrospray and atmospheric pressure chemical ionization (ESCi)-TOF-MS.

  2013cites this paper
• Simultaneous Determination of Cortisol, Cortisone, and 6β-Hydroxycortisol in Human Urine by UPLC with UV Detector and Application to Determine Diurnal Variations

  2012cites this paper
• Quantitation of Urinary 6ß-Hydroxycortisol and Free Cortisol by Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry

  2012cites this paper
• Detection of cortisol at a gold nanoparticle|Protein G-DTBP-scaffold modified electrochemical immunosensor.

  2011cites this paper
• Simultaneous determination of urinary cortisol, cortisone and corticosterone in parachutists, depressed patients and healthy controls in view of biomedical and pharmacokinetic studies.

  2011cites this paper
• Katedra i Zakład Farmacji Fizycznej i Farmakokinetyki

  2011cites this paper
• General Methods for the Extraction, Purification, and Measurement of Steroids by Chromatography and Mass Spectrometry

  2010influential citation
• HPLC method for determination of fluorescence derivatives of cortisol, cortisone and their tetrahydro- and allo-tetrahydro-metabolites in biological fluids.

  2010cites this paper
• Analysis of Corticosteroids

  2010cites this paper
• A highly sensitive SPE- liquid/liquid extraction – RPLC analytical method for the determination of 6β-hydroxycortisol and cortisol in cancer patients' urine

  2010cites this paper
• Endogenous cortisol 6 beta-hydroxylation clearance is not an accurate probe for overall cytochrome P450 3A phenotyping in humans.

  2009cites this paper
• Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism

  2009cites this paper
• Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats

  2009cites this paper
• Simultaneous Determination of 6β-Hydroxycortisol and 6β-Hydroxycortisone in Human Urine by LC with UV Absorbance Detection

  2009cites this paper
• Emprego da cromatografia líquida de alta eficiência na determinação de cortisol sérico em substituição à técnica de radioimunoensaio

  2008cites this paper
• Assessment of 4-nitro-1,8-naphthalic anhydride reductase activity in homogenates of bakers' yeast by reversed-phase high-performance liquid chromatography.

  2007cites this paper