The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Inorganic Biochemistry

• Publication date

  2012-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jinorgbio.2012.02.016PMID 22459168PMCID PMC3586266
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probing the interaction of cisplatin with the human copper chaperone Atox1 by solution and in-cell NMR spectroscopy.

  2011cited by this paper
• Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

  2011cited by this paper
• The Role of the Methionines and Histidines in the Transmembrane Domain of Mammalian Copper Transporter 1 in the Cellular Accumulation of Cisplatin

  2010cited by this paper
• The Role of the Mammalian Copper Transporter 1 in the Cellular Accumulation of Platinum-Based Drugs

  2009cited by this paper
• Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B.

  2009cited by this paper
• The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin.

  2009cited by this paper
• Transport of Cisplatin by the Copper Efflux Transporter ATP7B

  2008cited by this paper
• Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1.

  2008cited by this paper
• Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin

  2006cited by this paper
• CDD: a conserved domain database for interactive domain family analysis

  2006cited by this paper
• Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.

  2006cited by this paper
• Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model--effects on cellular redox metabolism.

  2006cited by this paper
• Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake.

  2006cited by this paper
• The thioredoxin reductase/thioredoxin system: Novel redox targets for cancer therapy

  2005cited by this paper
• Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.

  2005cited by this paper
• Study of the reactions between platinum(II) complexes and L-methionine in the presence and absence of 5'-GMP.

  2005cited by this paper
• Cisplatin interaction with cysteine and methionine, a theoretical DFT study.

  2005cited by this paper
• Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.

  2004cited by this paper
• Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

  2004cited by this paper
• Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.

  2004cited by this paper
• The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells

  2004cited by this paper
• Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B.

  2004cited by this paper
• The role of copper transporters in the development of resistance to Pt drugs.

  2004cited by this paper
• The Distinct Roles of the N-terminal Copper-binding Sites in Regulation of Catalytic Activity of the Wilson's Disease Protein*

  2003cited by this paper
• The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells.

  2003cited by this paper
• HSAB principle applied to the time evolution of chemical reactions.

  2003cited by this paper
• Mass spectrometric studies of cisplatin-induced changes of hemoglobin.

  2003cited by this paper
• Selectivity in heavy metal- binding to peptides and proteins.

  2002cited by this paper
• Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures.

  2002cited by this paper
• Solution structure of the Cu(I) and apo forms of the yeast metallochaperone, Atx1.

  2001cited by this paper
• Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the Apo and Cu(I)-loaded States*

  2001cited by this paper
• Cisplatin-protein adducts are efficiently removed by glutathione but not by 5'-guanosine monophosphate.

  2001cited by this paper
• Role of antioxidant systems in human androgen‐independent prostate cancer cells

  2000cited by this paper
• Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).

  1999cited by this paper
• Mechanisms of reaction of L‐methionine with carboplatin and oxaliplatin in different media: a comparison with cisplatin

  1999cited by this paper
• Reactions of cisplatin hydrolytes with methionine, cysteine, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniques.

  1999cited by this paper
• Role of the Copper-binding Domain in the Copper Transport Function of ATP7B, the P-type ATPase Defective in Wilson Disease*

  1999cited by this paper
• Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution.

  1999cited by this paper
• Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

  1998cited by this paper
• Further delineation of the molecular pathology of Wilson disease in the Mediterranean population

  1998cited by this paper
• Analysis of functional domains of Wilson disease protein (ATP7B) in Saccharomyces cerevisiae

  1998cited by this paper
• Metal ion chaperone function of the soluble Cu(I) receptor Atx1.

  1997cited by this paper
• CPx-type ATPases: a class of P-type ATPases that pump heavy metals.

  1996cited by this paper
• Copper and Silver Transport by CopB-ATPase in Membrane Vesicles of Enterococcus hirae(*)

  1995cited by this paper
• Two trans-Acting Metalloregulatory Proteins Controlling Expression of the Copper-ATPases of Enterococcus hirae*

  1995cited by this paper
• Thiol-related mechanisms of resistance in a murine tumor model.

  1994cited by this paper
• Reaction of cis- and trans-[PtCl2(NH3)2] with reduced glutathione inside human red blood cells, studied by 1H and 15N-[1H] DEPT NMR.

  1990cited by this paper
• Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug.

  1989cited by this paper
• Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles.

  1987cited by this paper

• A key heavy metal-binding protein orchestrates plant resistance against a geminivirus

  2024cites this paper
• Copper homeostasis and cuproptosis in gynecological disorders: Pathogenic insights and therapeutic implications.

  2024cites this paper
• Structures of the human Wilson disease copper transporter ATP7B.

  2023cites this paper
• Sensitization of cancer cells towards Cisplatin and Carboplatin by protein kinase D inhibitors through modulation of ATP7A/B (copper transport ATPases).

  2022cites this paper
• Interference between copper transport systems and platinum drugs.

  2021cites this paper
• The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

  2020cites this paper
• Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

  2019cites this paper
• Activity and Trafficking of Copper-Transporting ATPases in Tumor Development and Defense against Platinum-Based Drugs

  2019cites this paper
• ATP7B Binds Ruthenium(II) p-Cymene Half-Sandwich Complexes: Role of Steric Hindrance and Ru-I Coordination in Rescuing the Sequestration.

  2019cites this paper
• Synthetic lethality screening identifies FDA-approved drugs that overcome ATP7B-mediated tolerance of tumor cells to cisplatin

  2019cites this paper
• Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death

  2018cites this paper
• ATP7B rs9535826 is associated with gastrointestinal toxicity of platinum-based chemotherapy in nonsmall cell lung cancer patients

  2018cites this paper
• Enhancer of zeste homolog 2 promotes cisplatin resistance by reducing cellular platinum accumulation

  2018cites this paper
• Differential Reactivity of Metal Binding Domains of Copper ATPases towards Cisplatin and Colocalization of Copper and Platinum.

  2018cites this paper
• Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy

  2018cites this paper
• Tetrathiomolybdate inhibits the reaction of cisplatin with human copper chaperone Atox1.

  2018cites this paper
• Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

  2018cites this paper
• Facilitating the Cellular Accumulation of Pt-Based Chemotherapeutic Drugs

  2018cites this paper
• A Role for The ATP7A Copper Transporter in Tumorigenesis and Cisplatin Resistance

  2017cites this paper
• Lysosomes as mediators of drug resistance in cancer.

  2016cites this paper
• Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.

  2016cites this paper
• miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

  2016cites this paper
• An investigation of the pharmacogenetic basis of toxicity to platinum chemotherapy agents

  2016cites this paper
• ATP7B expression confers multidrug resistance through drug sequestration

  2016cites this paper
• Metal toxicity and the p53 protein: an intimate relationship

  2015cites this paper
• Thiosemicarbazone-Pt(II) Complex Causes a Growth Inhibitory Effect on Human Mesenchymal Stem Cells.

  2015cites this paper
• Cisplatin inhibits MEK1/2

  2015cites this paper
• Recording of Pump and Transporter Activity Using Solid‐Supported Membranes (SSM‐Based Electrophysiology)

  2015cites this paper
• Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

  2015cites this paper
• Role of transporters in the distribution of platinum-based drugs

  2015cites this paper
• Translocation of platinum anticancer drugs by human copper ATPases ATP7A and ATP7B.

  2014cites this paper
• Platination of the copper transporter ATP7A involved in anticancer drug resistance.

  2014cites this paper
• Biochemical characterization of P-type copper ATPases

  2014cites this paper
• The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

  2014cites this paper
• Transporting platinum drugs from a copper chaperone to ATPase: the mechanistic implication of drug efflux mediated cisplatin resistance

  2014cites this paper
• Cisplatin inhibits the formation of a reactive intermediate during copper-catalyzed oxidation of amyloid β peptide.

  2014cites this paper
• The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients

  2014cites this paper
• Cisplatin handover between copper transporters: the effect of reducing agents

  2014cites this paper
• Copper Transporting ATPases in Mammalian Cells

  2013cites this paper
• Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.

  2013cites this paper
• Determinants for Simultaneous Binding of Copper and Platinum to Human Chaperone Atox1: Hitchhiking not Hijacking

  2013influential citation
• The role of metal binding and phosphorylation domains in the regulation of cisplatin-induced trafficking of ATP7B.

  2013cites this paper
• Copper-transporting proteins and their interactions with platinum-based anticancer substances

  2013cites this paper
• Molecular Genetics of Wilson Disease

  2013cites this paper
• Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

  2012cites this paper