Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  European journal of medicinal chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ejmech.2017.10.041PMID 29126726
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.

  2017cited by this paper
• Hybrid Compounds as Multitarget Directed Anticancer Agents.

  2017cited by this paper
• The reversal of multidrug resistance in ovarian carcinoma cells by co-application of tariquidar and paclitaxel in transferrin-targeted polymeric micelles

  2017cited by this paper
• Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.

  2017cited by this paper
• Tyrosine kinase inhibitors in chronic myeloid leukaemia: which, when, for whom?

  2017cited by this paper
• N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy.

  2017cited by this paper
• Design, synthesis, biological evaluation, molecular docking and QSAR studies of 2,4-dimethylacridones as anticancer agents.

  2017cited by this paper
• GSK1904529A, a Potent IGF‐IR Inhibitor, Reverses MRP1‐Mediated Multidrug Resistance

  2017cited by this paper
• Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.

  2016cited by this paper
• Understanding the role of tariquidar, a potent Pgp inhibitor, in combination trials with cytotoxic drugs: What is missing?

  2016cited by this paper
• Whole-Body Distribution and Radiation Dosimetry of 11C-Elacridar and 11C-Tariquidar in Humans

  2016cited by this paper
• Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of paclitaxel as a novel P-glycoprotein inhibitor.

  2016cited by this paper
• The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.

  2015cited by this paper
• Discovery of Novel P‐Glycoprotein‐Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry

  2014cited by this paper
• Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents.

  2014cited by this paper
• Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents.

  2014cited by this paper
• CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.

  2014cited by this paper
• The cellular thermal shift assay for evaluating drug target interactions in cells

  2014cited by this paper
• Towards understanding promiscuity in multidrug efflux pumps.

  2014cited by this paper
• Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

  2013cited by this paper
• P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives.

  2013cited by this paper
• Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

  2012cited by this paper
• Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

  2009cited by this paper
• Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs.

  2007cited by this paper
• Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.

  2007cited by this paper
• Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.

  2006cited by this paper
• Targeting multidrug resistance in cancer

  2006cited by this paper
• Structure of multidrug-resistance proteins of the ATP-binding cassette (ABC) superfamily.

  2004cited by this paper
• Multidrug resistance reversal agents.

  2003cited by this paper
• Mechanisms of cancer drug resistance.

  2002cited by this paper
• Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

  1992cited by this paper
• Expression of a multidrug-resistance gene in human tumors and tissues.

  1987cited by this paper

• Novel 1,2,3-triazole-based compound triggers apoptosis through DNA damage response involving ATM/ATR signaling in liver cancer cells.

  2026cites this paper
• Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell.

  2025cites this paper
• A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential

  2025cites this paper
• Cell-Based Screen Identifies a Highly Potent and Orally Available ABCB1 Modulator for Treatment of Multidrug Resistance.

  2024cites this paper
• Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance.

  2024cites this paper
• Structural modification strategies of triazoles in anticancer drug development.

  2024cites this paper
• Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell.

  2024cites this paper
• Metabolic vulnerability of cancer stem cells and their niche

  2024cites this paper
• Acquired resistance to tyrosine kinase targeted therapy: mechanism and tackling strategies.

  2024cites this paper
• CIGB-300 reverses chemo-resistance in MDR1-transfected lung squamous cancer cells

  2024cites this paper
• Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.

  2023cites this paper
• Discovery of (quinazolin-6-yl)benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

  2023cites this paper
• Pyrrolizine/indolizine-bearing (un)substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and in silico studies

  2023cites this paper
• Design and synthesis of cabotegravir derivatives bearing 1,2,3-triazole and evaluation of anti-liver cancer activity

  2023cites this paper
• Photocatalytic generation of 1,4-disubstituted 1,2,3-triazoles under metal, oxidant and azide-free conditions

  2023cites this paper
• Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell.

  2023cites this paper
• Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

  2022cites this paper
• Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discovery

  2022cites this paper
• Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.

  2021cites this paper
• Dihydro-β-agarofuran-Type Sesquiterpenoids from the Seeds of Celastrus virens and Their Multidrug Resistance Reversal Activity against the KB/VCR Cell Line.

  2021cites this paper
• A New Pyrimidine Schiff Base with Selective Activities against Enterococcus faecalis and Gastric Adenocarcinoma

  2021cites this paper
• New Methods for Synthesis of 1,2,3-Triazoles: A Review

  2021cites this paper
• CMP25, a synthetic new agent, targets multidrug resistance-associated protein 7 (MRP7/ABCC10).

  2021cites this paper
• Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives.

  2021cites this paper
• Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.

  2021cites this paper
• Discovery of the Triazolo[1,5-a]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance.

  2021cites this paper
• Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)

  2020cites this paper
• The study on the interactions of two 1,2,3-triazoles with several biological macromolecules by multiple spectroscopic methodologies and molecular docking.

  2020cites this paper
• Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions.

  2020cites this paper
• Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters.

  2020cites this paper
• Computationally Designed Synthetic Peptides for Transporter Proteins Imparts Allostericity in Miltefosine Resistant Leishmania major.

  2020cites this paper
• Synthesis of 1,2,3 triazole‐linked pyrimidines catalyzed by mg‐Al‐LDH‐immobilized‐CuI as a heterogeneous catalyst

  2020cites this paper
• Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators.

  2020cites this paper
• 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

  2019cites this paper
• Jatrophane Diterpenoids from Euphorbia glomerulans.

  2019cites this paper
• An Easy Access to 4‐Trifluoromethylated 7‐(4‐Substitued‐1 H ‐1,2,3‐Triazol‐1‐yl)Pyrimido[1,2‐ b ]Pyridazin‐2‐One Systems

  2019cites this paper
• Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

  2019cites this paper
• 1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.

  2019cites this paper
• Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.

  2019cites this paper
• Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance.

  2019cites this paper
• Reusable Pd@PEG Catalyst for Aerobic Dehydrogenative C-H/C-H Arylations of 1,2,3-Triazoles.

  2019cites this paper
• Natural phosphate-supported Cu(ii), an efficient and recyclable catalyst for the synthesis of xanthene and 1,4-disubstituted-1,2,3-triazole derivatives

  2018cites this paper
• Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance.

  2018cites this paper
• Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore.

  2018cites this paper
• Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.

  2018cites this paper
• Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

  2018cites this paper
• A continuous flow approach for the C–H functionalization of 1,2,3-triazoles in γ-valerolactone as a biomass-derived medium

  2018cites this paper
• Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.

  2018cites this paper
• Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR).

  2018cites this paper