Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity

Graphical abstract

• Publication year

  2018

• Venue

  International Journal of Parasitology

• Publication date

  2018-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ijpara.2018.01.005PMID 29530646PMCID 6018611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel Bioengineered Three-Dimensional Human Intestinal Model for Long-Term Infection of Cryptosporidium parvum

  2017cited by this paper
• Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum

  2017cited by this paper
• Continuous culture of Cryptosporidium parvum using hollow fiber technology.

  2016cited by this paper
• Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics

  2016cited by this paper
• Genetic modification of the diarrheal pathogen Cryptosporidium parvum

  2015cited by this paper
• Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics

  2015cited by this paper
• Inhibition of Calcium-Dependent Protein Kinase 1 (CDPK1) In Vitro by Pyrazolopyrimidine Derivatives Does Not Correlate with Sensitivity of Cryptosporidium parvum Growth in Cell Culture

  2015cited by this paper
• A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

  2015cited by this paper
• Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study.

  2013cited by this paper
• Vivo-Morpholinos Induced Transient Knockdown of Physical Activity Related Proteins

  2013cited by this paper
• Sporozoite proteome analysis of Cryptosporidium parvum by one-dimensional SDS-PAGE and liquid chromatography tandem mass spectrometry

  2013cited by this paper
• Targeted Skipping of Human Dystrophin Exons in Transgenic Mouse Model Systemically for Antisense Drug Development

  2011cited by this paper
• Genetic richness and diversity in Cryptosporidium hominis and C. parvum reveals major knowledge gaps and a need for the application of "next generation" technologies--research review.

  2010cited by this paper
• Antiviral and Neuroprotective Role of Octaguanidinium Dendrimer-Conjugated Morpholino Oligomers in Japanese Encephalitis

  2010cited by this paper
• First description of Cryptosporidium bovis in Japan and diagnosis and genotyping of Cryptosporidium spp. in diarrheic pre-weaned calves in Hokkaido.

  2010cited by this paper
• Octa-guanidine morpholino restores dystrophin expression in cardiac and skeletal muscles and ameliorates pathology in dystrophic mdx mice.

  2009cited by this paper
• Design and synthesis of dendritic molecular transporter that achieves efficient in vivo delivery of morpholino antisense oligo.

  2008cited by this paper
• Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues.

  2008cited by this paper
• High-yield amplification of Cryptosporidium parvum in interferon γ receptor knockout mice

  2008cited by this paper
• Detection and quantification of Cryptosporidium in HCT-8 cells and human fecal specimens using real-time polymerase chain reaction.

  2007cited by this paper
• Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos.

  2007cited by this paper
• The genome of Cryptosporidium hominis

  2004cited by this paper
• Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

  2004cited by this paper
• Ultrastructure of Cryptosporidium muris (strain RN 66) parasitizing the murine stomach

  2004cited by this paper
• Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

  2004cited by this paper
• Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplication.

  2003cited by this paper
• A review of the importance of cryptosporidiosis in farm animals

  1999cited by this paper
• The Gamma Interferon Gene Knockout Mouse: a Highly Sensitive Model for Evaluation of Therapeutic Agents againstCryptosporidium parvum

  1998cited by this paper
• Glycolytic enzyme activities in Cryptosporidium parvum oocysts.

  1997cited by this paper
• Comparative development of Cryptosporidium parvum (Apicomplexa) in 11 continuous host cell lines.

  1994cited by this paper
• Techniques and laboratory maintenance of Cryptosporidium.

  1990cited by this paper
• Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients.

  1987cited by this paper
• A comparison of endogenous development of three isolates of Cryptosporidium in suckling mice.

  1986cited by this paper

• Establishing TurboID Proximity Labeling and mAID Conditional Knockdown System in Cryptosporidium parvum.

  2026cites this paper
• Treating cryptosporidiosis: A review on drug discovery strategies

  2024cites this paper
• Emerging therapeutic avenues against Cryptosporidium: A comprehensive review.

  2024cites this paper
• The intersection of host in vivo metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites

  2024cites this paper
• Molecular insights into anti-Protozoal action of natural compounds against Cryptosporidium parvum: a molecular simulation study

  2023cites this paper
• Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

  2023cites this paper
• Cryptosporidium parvum Pyruvate Kinase Inhibitors With in vivo Anti-cryptosporidial Efficacy

  2022cites this paper
• Cryptosporidium

  2022cites this paper
• Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis

  2021cites this paper
• Insulinase-like Protease 1 Contributes to Macrogamont Formation in <named-content content-type='genus-species'>Cryptosporidium parvum</named-content>

  2021cites this paper
• Gut metabolites influence susceptibility of neonatal mice to cryptosporidiosis

  2020cites this paper
• Defining Stage-Specific Activity of Potent New Inhibitors of Cryptosporidium parvum Growth In Vitro

  2020cites this paper
• Cryptosporidium: host and parasite transcriptome in infection.

  2020cites this paper
• Viruses of protozoan parasites and viral therapy: Is the time now right?

  2020cites this paper
• Development of an in vitro Culture System for Cryptosporidium parvum

  2020cites this paper
• Insulinase-like Protease 1 Contributes to Macrogamont Formation in Cryptosporidium parvum

  2020cites this paper
• Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells

  2020cites this paper
• Forward Genetics in Cryptosporidium Enabled by Complete in Vitro Development in Stem Cell-Derived Intestinal Epithelium

  2019cites this paper
• A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability

  2019cites this paper
• Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum

  2019cites this paper
• Recent Breakthroughs and Ongoing Limitations in Cryptosporidium Research

  2018cites this paper