Analysis of the defect in DNA end joining in the murine scid mutation

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Molecular and Cellular Biology

• Publication date

  1992-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.12.10.4758-4768.1992PMID 1406659PMCID PMC360403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Site‐specific recombination in the immune system 1

  1991cited by this paper
• Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P‐nucleotide additions in VJ‐coding joints

  1991cited by this paper
• A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

  1991cited by this paper
• V(D)J recombination: evidence that a replicative mechanism is not required

  1991cited by this paper
• scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

  1991cited by this paper
• Strand breaks without DNA rearrangement in V (D)J recombination

  1991cited by this paper
• T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.

  1990cited by this paper
• The scid mutation in mice causes a general defect in DNA repair

  1990cited by this paper
• Wild-type V(D)J recombination in scid pre-B cells.

  1990cited by this paper
• A novel pathway of DNA end-to-end joining.

  1990cited by this paper
• Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

  1989cited by this paper
• Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.

  1989cited by this paper
• Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments.

  1989cited by this paper
• The mechanism of antigen receptor gene assembly.

  1989cited by this paper
• Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin.

  1989cited by this paper
• Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

  1988cited by this paper
• The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

  1988cited by this paper
• The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism.

  1988cited by this paper
• Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

  1988cited by this paper
• Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

  1988cited by this paper
• Novel strand exchanges in V(D)J recombination.

  1988cited by this paper
• Developmental stage specificity of the lymphoid V(D)J recombination activity.

  1987cited by this paper
• Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.

  1987cited by this paper
• Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

  1986cited by this paper
• Mechanisms of nonhomologous recombination in mammalian cells

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• A severe combined immunodeficiency mutation in the mouse

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• QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

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• The Association between Inefficient Repair of DNA Double-Strand Breaks and Common Polymorphisms of the HRR and NHEJ Repair Genes in Patients with Rheumatoid Arthritis

  2024cites this paper
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• Deciphering phenotypic variance in different models of DNA-PKcs deficiency.

  2019influential citation
• The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove.

  2016cites this paper
• Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

  2015cites this paper
• Ku70 and non-homologous end joining protect testicular cells from DNA damage

  2013cites this paper
• The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.

  2010influential citation
• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞

  2009cites this paper
• DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ

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• Histone H1 functions as a stimulatory factor in backup pathways of NHEJ

  2008influential citation
• APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.

  2008cites this paper
• Characterization of APLF in the Nonhomologous End-joining Pathway

  2008cites this paper
• The catalytic subunit of DNA–protein kinase (DNA-PKcs) is not required for Ig class-switch recombination

  2007cites this paper
• Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.

  2006cites this paper
• Complementation of the Radiosensitive Phenotype in Severe Combined Inimunodeliden t Mice by Human Chromosome 81

  2006cites this paper
• The seid Factor on Human Chromosome 8 Restores V ( D ) J Recombination in Addition to Double-Strand Break Repair 1

  2006cites this paper
• Advances in Brief p53-dependent Cell Cycle Arrests Are Preserved in DNA-activated Protein Kinase- deficient Mouse Fibroblasts1

  2006cites this paper
• DNA ligase III as a candidate component of backup pathways of nonhomologous end joining.

  2005influential citation
• Mechanisms of DNA double strand break repair and chromosome aberration formation

  2004cites this paper
• MDC1 Regulates DNA-PK Autophosphorylation in Response to DNA Damage*

  2004cites this paper
• Efficient nonhomologous and homologous recombination in scid cells

  2004cites this paper
• DNA Repair Defects in Cancer

  2004cites this paper
• Cancer Diagnostics

  2004cites this paper
• Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

  2004cites this paper
• Backup pathways of NHEJ are suppressed by DNA‐PK

  2004cites this paper
• Biochemical evidence for Ku-independent backup pathways of NHEJ.

  2003cites this paper
• Biased T-Cell Receptor 8 Element Recombination in scid Thymocytes

  2003cites this paper
• Chk 2 Phosphorylation of BRCA 1 Regulates DNA Double-Strand Break Repair

  2003cites this paper
• DNA-PK and ATM are Required for Radiation-Enhanced Integration

  2002cites this paper
• Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis

  2002cites this paper
• DNA-dependent Protein Kinase Activity Is Not Required for Immunoglobulin Class Switching

  2002cites this paper
• SCID and Wild-Type Mice Nonhairpin Coding Ends in Thymocytes of Variable Diversity Joining Recombination:

  2002cites this paper
• Variable Diversity Joining Recombination: Nonhairpin Coding Ends in Thymocytes of SCID and Wild-Type Mice1

  2002cites this paper
• Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.

  2002cites this paper
• Gamma-irradiation directly affects the formation of coding joints in SCID cell lines.

  1999cites this paper
• DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity.

  1999cites this paper
• Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells.

  1999cites this paper
• DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.

  1998cites this paper
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  1998cites this paper
• DNA-Dependent Protein Kinase Phosphorylation of I k B a and I k B b Regulates NFk B DNA Binding Properties

  1998influential citation
• Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining.

  1998cites this paper
• DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

  1998influential citation
• The fidelity of double strand breaks processing is impaired in complementation groups B and D of fanconi anemia, a genetic instability syndrome

  1997cites this paper
• Increased sensitivity of scid heterozygous mice to ionizing radiation.

  1997cites this paper
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  1997cites this paper
• Inactivation of p53 results in high rates of homologous recombination

  1997cites this paper
• The scid defect results in much slower repair of DNA double-strand breaks but not high levels of residual breaks.

  1997cites this paper
• p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts.

  1996cites this paper
• Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA*

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• Double-strand breaks, DNA hairpins, and the mechanism of V(D)J recombination.

  1996cites this paper
• Analysis of the CDR3 region of the rearranged IgH chain genes in patients with severe combined immunodeficiency and severe lymphopenia.

  1996cites this paper
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  1995cites this paper
• Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination.

  1995cites this paper
• Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8.

  1995cites this paper
• V(D)J recombination and double-strand break repair.

  1995cites this paper
• Human immunodeficiency virus infection of xenografted SCID‐beige mice

  1995cites this paper
• The variable region gene assembly mechanism

  1995cites this paper
• The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair.

  1995cites this paper
• Stimulation of Defective DNA Transfer Activity in Recombination Deficient SCID Cell Extracts by a 72-kDa Protein from Wild-type Thymocytes (*)

  1995cites this paper
• Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells.

  1994cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses.

  1994cites this paper
• scid cells efficiently integrate hairpin and linear DNA substrates

  1994cites this paper
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  1994cites this paper
• Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point.

  1993cites this paper
• Biased T-cell receptor delta element recombination in scid thymocytes

  1993cites this paper
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  1993cites this paper
• Characterization of the DNA double strand break repair defect in scid mice.

  1993cites this paper
• Primary T-cell immunodeficiencies.

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• Unequal signal and coding joint formation in human V(D)J recombination

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  1993cites this paper
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  1993influential citation
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  1993cites this paper
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  1993cites this paper
• V(D)J recombination in peritoneal B cells of leaky scid mice

  1993cites this paper
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  1993cites this paper
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  1993cites this paper
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  1992cites this paper
• A V(D)J site-specific recombination model involving no compulsory double-stranded break formation at the coding segments.

  1992cites this paper