Mouse models and the evolutionary developmental biology of the skull.

Understanding development is relevant to understanding evolution because developmental processes structure the expression of phenotypic variation upon which natural selection acts. Advances in developmental biology are fueling a new synthesis of developmental and evolutionary biology, but it remains unclear how to use developmental information that largely derives from a few model organisms to test hypotheses about the evolutionary developmental biology of taxa such as humans and other primates that have not been or are not amenable to direct study through experimental developmental biology. In this article, we discuss how and when model organisms like mice are useful for studying the evolutionary developmental biology of even rather distantly related and morphologically different groups like primates. A productive approach is to focus on processes that are likely to play key roles in producing evolutionarily significant phenotypic variation across a large phylogenetic range. We illustrate this approach by applying the analysis of craniofacial variation in mouse mutant models to primate and human evolution.

• Publication year

  2008

• Venue

  Integrative and Comparative Biology

• Publication date

  2008-06-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/icb/icn076PMID 21669799
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adaptation and Natural Selection. (Book Reviews: Adaptation and Natural Selection: A Critique of Some Current Evolutionary Thought)

  2018influential reference
• Evolutionary Developmental Biology

  2010cited by this paper
• Evolutionary Developmental Biology

  2009cited by this paper
• Spatial packing, cranial base angulation, and craniofacial shape variation in the mammalian skull: testing a new model using mice

  2008cited by this paper
• A Novel 3-D Image-Based Morphological Method for Phenotypic Analysis

  2008cited by this paper
• Evolution of covariance in the mammalian skull.

  2007cited by this paper
• Phenotypic Variability: Its Components, Measurement and Underlying Developmental Processes

  2007cited by this paper
• The choice of model organisms in evo–devo

  2007influential reference
• Evolvability as the proper focus of evolutionary developmental biology

  2007cited by this paper
• The relationship between development and evolution through heritable variation.

  2007influential reference
• Inactivation of Pten in Osteo‐Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth

  2007cited by this paper
• Epigenetic interactions and the structure of phenotypic variation in the cranium

  2007cited by this paper
• The conceptual and statistical relationship between modularity and morphological integration.

  2007cited by this paper
• The brachymorph mouse and the developmental‐genetic basis for canalization and morphological integration

  2006cited by this paper
• Canalization and developmental stability in the Brachyrrhine mouse

  2006cited by this paper
• Tissue distribution and ontogeny of sulfotransferase enzymes in mice.

  2006influential reference
• The age of model organisms

  2004influential reference
• Testing hypotheses about tinkering in the fossil record: the case of the human skull.

  2004cited by this paper
• The biology and clinical relevance of the PTEN tumor suppressor pathway.

  2004influential reference
• Correlated response in skeletal traits and replicate variation in selected lines of mice

  2004cited by this paper
• Craniofacial variability and modularity in macaques and mice.

  2004cited by this paper
• Truncation of the Shaker‐like voltage‐gated potassium channel, Kv1.1, causes megencephaly

  2003cited by this paper
• MRI and in situ hybridization reveal early disturbances in brain size and gene expression in the megencephalic (mceph/mceph) mouse

  2003cited by this paper
• A gene network model accounting for development and evolution of mammalian teeth

  2002cited by this paper
• Integration, phylogeny, and the hominid cranial base.

  2001influential reference
• Anthropoid cranial base architecture and scaling relationships.

  2001influential reference
• The genetic architecture of divergence between threespine stickleback species

  2001cited by this paper
• Embracing complexity: Organicism for the 21st century

  2000influential reference
• The primate cranial base: ontogeny, function, and integration.

  2000cited by this paper
• Evo-devo: the evolution of a new discipline

  2000influential reference
• Basicranial influence on overall cranial shape.

  2000cited by this paper
• Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse

  1998cited by this paper
• A member of a family of sulfate-activating enzymes causes murine brachymorphism.

  1998cited by this paper
• The functional matrix hypothesis revisited. 4. The epigenetic antithesis and the resolving synthesis.

  1997cited by this paper
• The functional matrix hypothesis revisited. 2. The role of an osseous connected cellular network.

  1997cited by this paper
• The functional matrix hypothesis revisited. 3. The genomic thesis.

  1997cited by this paper
• Basicranial architecture and relative brain size of Sts 5 (Australopithecus africanus) and other Plio-Pleistocene hominids

  1997cited by this paper
• The functional matrix hypothesis revisited. 1. The role of mechanotransduction.

  1997influential reference
• Developmental Integration and the Evolution of Pleiotropy

  1996cited by this paper
• Basicranial flexion, relative brain size, and facial kyphosis in Homo sapiens and some fossil hominids.

  1995cited by this paper
• Pattern in craniofacial biology: Evidence from the old world monkeys (Cercopithecidae)

  1994cited by this paper
• Cultured circulating mononuclear cells from osteopetrotic infants express the osteoclast‐associated vitronectin receptor and form multinucleated cells in response to 1,25‐dihydroxyvitamin D3

  1993cited by this paper
• The ontogenetic complexity of developmental constraints

  1993cited by this paper
• Basicranial flexion, relative brain size, and facial kyphosis in nonhuman primates.

  1993influential reference
• Wonderful Life: The Burgess Shale and the Nature of History

  1989cited by this paper
• ONTOGENETIC VARIATION IN PATTERNS OF DEVELOPMENTAL AND FUNCTIONAL INTEGRATION IN SKULLS OF SIGMODON FULVIVENTER

  1989cited by this paper
• A zebrafish homeobox-containing gene with embryonic transcription.

  1987cited by this paper
• Ontogeny and Phylogeny

  1980cited by this paper
• Ontogeny and Phylogeny.

  1978cited by this paper
• Functional growth boundaries in the human and mammalian face.

  1975cited by this paper
• Facial growth.

  1971cited by this paper
• Primates: Studies in adaptation and variability. Edited by Phyllis C. Jay. 541 pp. illustrated. Holt, Rinehart & Winston, New York. 1968. $7.95

  1969cited by this paper
• Classification and human evolution

  1963cited by this paper
• A functional approach to craniology.

  1960influential reference

• The interplay of tissue mechanics and gene regulatory networks in the evolution of morphogenesis.

  2025cites this paper
• Craniofacial morphology of TcMAC21 and TcHSA21rat models of Down syndrome: An interspecific comparison.

  2025cites this paper
• Adaptation of the In Situ Hybridization Method for Working with Embryos and Larvae of Modern Representatives of Phylogenetically Ancient Groups of Vertebrates: Lampreys, Cartilaginous Fishes and Sturgeons

  2024cites this paper
• Commensal Microbiota Effects on Craniofacial Skeletal Growth and Morphology

  2023cites this paper
• Embryonic and early postnatal cranial bone volume and tissue mineral density values for C57BL/6J laboratory mice

  2022cites this paper
• Early life malnutrition and fluctuating asymmetry in the rat bony labyrinth

  2021cites this paper
• Different transformations underlie blowhole and nasal passage development in a toothed whale (Odontoceti: Stenella attenuata) and a baleen whale (Mysticeti: Balaenoptera physalus)

  2021cites this paper
• Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape

  2021cites this paper
• Cranial synchondroses of primates at birth

  2020cites this paper
• Differential cellular proliferation underlies heterochronic generation of cranial diversity in phyllostomid bats

  2020cites this paper
• Morphometrics in Evolutionary Developmental Biology

  2020cites this paper
• Shapes and Genescapes: Mapping Multivariate Phenotype-Biological Process Associations for Craniofacial Shape

  2020cites this paper
• Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

  2020cites this paper
• Ontogenetic changes in magnitudes of integration in the macaque skull.

  2020cites this paper
• From Phenotype to Genotype And Back Again

  2019cites this paper
• Craniofacial skeletal response to encephalization: How do we know what we think we know?

  2019influential citation
• Integrating data on bone modeling and morphological ontogenetic changes of the maxilla in modern humans.

  2019cites this paper
• Description and Analysis of Spatial Patterns in Geometric Morphometric Data

  2019cites this paper
• Developmental constraint through negative pleiotropy in the zygomatic arch

  2018cites this paper
• Predicting the bending properties of long bones: Insights from an experimental mouse model.

  2018cites this paper
• A century of development.

  2018cites this paper
• One skull to rule them all? Descriptive and comparative anatomy of the masticatory apparatus in five mouse species

  2018cites this paper
• FoxO6 regulates Hippo signaling and growth of the craniofacial complex

  2018cites this paper
• Developmental variation and morphological integration between chondrocranial- and intramembranous-derived craniofacial skeletal components in a cross-sectional sample of C57BL6/J and C3H/HeJ mice

  2018influential citation
• Mouse models for the study of cranial base growth and anomalies.

  2017cites this paper
• Morphological covariation and growth of the skull in the house mouse (Mus musculus): the role of Robertsonian translocations in a zone of chromosomal polymorphism /

  2017cites this paper
• Impact of Hybridization on Shape, Variation and Covariation of the Mouse Molar

  2017cites this paper
• Morphological interaction between the nasal septum and nasofacial skeleton during human ontogeny

  2017cites this paper
• Characterisation of chiari-like malformation and secondary syringomyelia in selected toy dog breeds using magnetic resonance imaging.

  2017cites this paper
• What affects the predictability of evolutionary constraints using a G‐matrix? The relative effects of modular pleiotropy and mutational correlation

  2017cites this paper
• Postnatal Ontogeny of the Cranial Base and Craniofacial Skeleton in Male C57BL/6J Mice: A Reference Standard for Quantitative Analysis

  2016cites this paper
• New molecular mechanisms controlling dental epithelial stem cell maintenance, growth and craniofacial morphogenesis

  2016cites this paper
• A Phylogenetic Analysis of Shape Covariance Structure in the Anthropoid Skull

  2016cites this paper
• Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses.

  2016cites this paper
• Cranial base topology and basic trends in the facial evolution of Homo.

  2016cites this paper
• A resistant method for landmark-based analysis of individual asymmetry in two dimensions

  2016cites this paper
• Multivariate Analysis of Genotype–Phenotype Association

  2016cites this paper
• The Nervous System Orchestrates and Integrates Craniofacial Development: A Review

  2016cites this paper
• Epistasis and Pleiotropy Affect the Modularity of the Genotype–Phenotype Map of Cross-Resistance in HIV-1

  2016cites this paper
• Desarrollo prenatal del cráneo y el cerebro en un modelo de restricción del crecimiento en ratones / Prenatal development of skull and brain in a mouse model of growth restriction

  2016cites this paper
• Modularity and Morphometrics: Error Rates in Hypothesis Testing

  2015influential citation
• Chondrocranial Growth, Developmental Integration and Evolvability in the Human Skull

  2015cites this paper
• A multivariate approach to assess variation in tooth mineralization using free-lived and captive-raised chimpanzees (P. troglodytes).

  2015cites this paper
• Encephalization and diversification of the cranial base in platyrrhine primates.

  2015cites this paper
• Phylogeny, Ecology, and Morphological Evolution in the Atelid Cranium

  2015cites this paper
• Mind the Gap: Genetic Manipulation of Basicranial Growth within Synchondroses Modulates Calvarial and Facial Shape in Mice through Epigenetic Interactions

  2015cites this paper
• The Role of Evolutionary Integration in the Morphological Evolution of the Skull of Caviomorph Rodents (Rodentia: Hystricomorpha)

  2015cites this paper
• Evo-Devo insights from pathological networks: exploring craniosynostosis as a developmental mechanism for modularity and complexity in the human skull.

  2015cites this paper
• Quantitative Genetics and Modularity in Cranial and Mandibular Morphology of Calomys expulsus

  2014influential citation
• Canalization and developmental instability of the fetal skull in a mouse model of maternal nutritional stress.

  2014cites this paper
• Convergencia en las proporciones craneanas entre primates del nuevo y el viejo mundo: un análisis craneofuncional / Convergence in cranial proportions in New and Old World primates: a craniofunctional analysis

  2014cites this paper
• FGFR1 signaling is associated with the magnitude of morphological integration in human head shape

  2014cites this paper
• Inestabilidad del desarrollo en estructuras cráneo-faciales de poblaciones humanas sudamericanas

  2014cites this paper
• Studying Developmental Variation with Geometric Morphometric Image Analysis (GMIA)

  2014cites this paper
• A Comparative Radiographic Investigation of Variation in Facial Projection in Anthropoid Primates

  2014cites this paper
• The influence of angiogenesis on craniofacial development and evolution

  2013cites this paper
• Nasal-Emission and Nose leaves

  2013cites this paper
• An Integrated Approach for Landmark-Based Resistant Shape Analysis in 3D

  2013cites this paper
• The morphology of the mouse masticatory musculature

  2013cites this paper
• Evolvability of the Primate Pelvic Girdle

  2012cites this paper
• How to Explore Morphological Integration in Human Evolution and Development?

  2012cites this paper
• If the skull fits: magnetic resonance imaging and microcomputed tomography for combined analysis of brain and skull phenotypes in the mouse.

  2012cites this paper
• Wiley‐Blackwell Encyclopedia of Human Evolution

  2012cites this paper
• brain and skull phenotypes in the mouse microcomputed tomography for combined analysis of If the skull fits: magnetic resonance imaging and

  2012cites this paper
• Interspecies difference in placement of developing teeth and its relationship with cross-sectional geometry of the mandibular symphysis in four primate species including modern humans.

  2012cites this paper
• The Developmental Basis of Quantitative Craniofacial Variation in Humans and Mice

  2012cites this paper
• The integrated phenotype.

  2012cites this paper
• ROLES FOR MODULARITY AND CONSTRAINT IN THE EVOLUTION OF CRANIAL DIVERSITY AMONG ANOLIS LIZARDS

  2012cites this paper
• Human EvoDevo

  2012cites this paper
• Effects of environmental perturbations during postnatal development on the phenotypic integration of the skull.

  2011cites this paper
• FGF/FGFR Signaling Coordinates Skull Development by Modulating Magnitude of Morphological Integration: Evidence from Apert Syndrome Mouse Models

  2011cites this paper
• Reviewing the Morphology of the Jaw‐Closing Musculature in Squirrels, Rats, and Guinea Pigs with Contrast‐Enhanced MicroCt

  2011cites this paper
• Integrating Different Biological Evidence Around Some Microevolutionary Processes: Bottlenecks and Asian-American Arctic Gene Flow in the New World Settlement

  2011cites this paper
• Epigenetics: Linking Genotype and Phenotype in Development and Evolution

  2011cites this paper
• Muscle-bone interactions and the development of skeletal phenotype

  2011cites this paper
• Ontogenetic Allometry and Cranial Shape Diversification Among Human Populations From South America

  2011cites this paper
• Heterochrony and developmental modularity of cranial osteogenesis in lipotyphlan mammals

  2011cites this paper
• Epigenetic integration of the developing brain and face

  2011cites this paper
• Mechanisms that underlie co‐variation of the brain and face

  2011cites this paper
• Genetic and environmental contributions to variation in baboon cranial morphology.

  2010cites this paper
• Endocranial shape changes during growth in chimpanzees and humans: a morphometric analysis of unique and shared aspects.

  2010cites this paper
• Cranial shape varies along an elevation gradient in Gambel's white‐footed mouse (Peromyscus maniculatus gambelii) in the Grinnell Resurvey Yosemite transect

  2010cites this paper
• Effects of brain and facial size on basicranial form in human and primate evolution.

  2010influential citation
• Developmental plasticity in covariance structure of the skull: effects of prenatal stress

  2010cites this paper
• The Developmental Basis of Variational Modularity: Insights from Quantitative Genetics, Morphometrics, and Developmental Biology

  2009cites this paper
• Developmental and Genetic Constraints on Neurocranial Globularity: Insights from Analyses of Deformed Skulls and Quantitative Genetics

  2009influential citation
• Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic Covariation

  2009cites this paper
• Phenotypic Integration Without Modularity: Testing Hypotheses About the Distribution of Pleiotropic Quantitative Trait Loci in a Continuous Space

  2009influential citation
• The Ontogenetic Trajectory of the Phenotypic Covariance Matrix, with Examples from Craniofacial Shape in Rats and Humans

  2009cites this paper
• Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice.

  2008cites this paper
• Building a better organismal model: The role of the mouse--Introduction to the symposium.

  2008influential citation