TOPDOM: database of domains and motifs with conservative location in transmembrane proteins

Summary: The TOPDOM database is a collection of domains and sequence motifs located consistently on the same side of the membrane in α-helical transmembrane proteins. The database was created by scanning well-annotated transmembrane protein sequences in the UniProt database by specific domain or motif detecting algorithms. The identified domains or motifs were added to the database if they were uniformly annotated on the same side of the membrane of the various proteins in the UniProt database. The information about the location of the collected domains and motifs can be incorporated into constrained topology prediction algorithms, like HMMTOP, increasing the prediction accuracy. Availability: The TOPDOM database and the constrained HMMTOP prediction server are available on the page http://topdom.enzim.hu Contact: tusi@enzim.hu; lkalmar@enzim.hu

• Publication year

  2008

• Venue

  Bioinform.

• Publication date

  2008-04-23

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1093/bioinformatics/btn202PMID 18434342PMCID 2427164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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