Functional IL-18 Is Produced by Primary Pancreatic Mouse Islets and NIT-1 Beta Cells and Participates in the Progression towards Destructive Insulitis

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Hormone Research in Paediatrics

• Publication date

  2002-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000057959PMID 12006705
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma.

  2000cited by this paper
• IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

  2000cited by this paper
• Combined Effects of IL-12 and IL-18 on the Induction of Collagen-Induced Arthritis1

  2000cited by this paper
• IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells

  2000cited by this paper
• Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism.

  2000cited by this paper
• Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage.

  2000cited by this paper
• Cellular and molecular roles of β cell autoantigens, macrophages and T cells in the pathogenesis of autoimmune diabetes

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• IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.

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• Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response.

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• Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells.

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• Regulation of interferon-γ production by IL-12 and IL-18

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• Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

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• Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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• Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

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• A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

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• Systemic production of interferon-gamma inducing factor (IGIF) versus local IFN-gamma expression involved in the development of Th1 insulitis in NOD mice.

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• Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

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• Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

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• Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

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• Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

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• T-cell regulation in murine and human autoimmune diabetes: the role of TH1 and TH2 cells.

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• Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

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• Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells

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• Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production.

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• IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones.

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• Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

  1996cited by this paper
• Cloning of a new cytokine that induces IFN-gamma production by T cells.

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• IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

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• T helper cell subsets in insulin-dependent diabetes.

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• Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4

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• Adoptive Transfer of Diabetes Into Immunodeficient NOD-scid/scid Mice: Relative Contributions of CD4+ and CD8+ T-Cells From Diabetic Versus Prediabetic NOD.NON-Thy-1a Donors

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• Altered cytokine activity in adjuvant inhibition of autoimmune diabetes.

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• NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse.

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• Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.

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• Insulin dependent diabetes mellitus as an autoimmune disease.

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• Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans

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• Adoptive transfer.

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• Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.

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• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

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