Spinal Cord Injury Research in Mice: 2008 Review

Spinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber tracts that carry sensation and motor signals to and from the brain. SCI is also associated with gray matter damage and often life-threatening secondary complications. This mini-review aims to provide the nonspecialist reader with a comprehensive description of recent advances made in 2008 using murine models of SCI. A variety of approaches, including advanced genetics and molecular techniques, have allowed a number of key findings in the field of secondary degeneration, repair, regeneration (including insights from peripheral nerve lesion models), metabolic dysfunctions, and pharmacological neuromodulation.

• Publication year

  2009

• Venue

  TheScientificWorldJournal

• Publication date

  2009-06-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1100/tsw.2009.63PMID 19526188PMCID 5823121
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NG2 cell response in the CNP‐EGFP mouse after contusive spinal cord injury

  2009cited by this paper
• Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death.

  2009cited by this paper
• BENEFICIAL EFFECTS OF ETHYL PYRUVATE IN A MOUSE MODEL OF SPINAL CORD INJURY

  2009cited by this paper
• CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model

  2009cited by this paper
• Vaccination with dendritic cells pulsed with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in mice

  2009cited by this paper
• Expression of Semaphorin3C in axotomized rodent facial and rubrospinal neurons.

  2008cited by this paper
• Histomorphometric and Densitometric Changes in the Femora of Spinal Cord Transected Mice

  2008cited by this paper
• The Yellow Fluorescent Protein (YFP-H) Mouse Reveals Neuroprotection as a Novel Mechanism Underlying Chondroitinase ABC-Mediated Repair after Spinal Cord Injury

  2008cited by this paper
• Antiallodynic and Antihyperalgesic Effect of Milnacipran in Mice with Spinal Nerve Ligation

  2008cited by this paper
• Deficiency in Complement C1q Improves Histological and Functional Locomotor Outcome after Spinal Cord Injury

  2008cited by this paper
• Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

  2008cited by this paper
• Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

  2008cited by this paper
• [Establishment and assessment of the mouse model for spinal cord injury].

  2008cited by this paper
• Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse

  2008cited by this paper
• In Vitro and In Vivo Characterization of Neurally Modified Mesenchymal Stem Cells Induced by Epigenetic Modifiers and Neural Stem Cell Environment

  2008cited by this paper
• Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection.

  2008cited by this paper
• Role of spinal 5‐HT2 receptor subtypes in quipazine‐induced hindlimb movements after a low‐thoracic spinal cord transection

  2008cited by this paper
• A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice.

  2008cited by this paper
• A Graded Forceps Crush Spinal Cord Injury Model in Mice

  2008cited by this paper
• Effects of Spinal α2-Adrenoceptor and I1-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice

  2008cited by this paper
• Undesired effects of a combinatorial treatment for spinal cord injury – transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus

  2008cited by this paper
• Local Inhibition of Rho Signaling by Cell-Permeable Recombinant Protein BA-210 Prevents Secondary Damage and Promotes Functional Recovery following Acute Spinal Cord Injury

  2008cited by this paper
• The protective effects of 15‐deoxy‐Δ‐12,14‐prostaglandin J2 in spinal cord injury

  2008cited by this paper
• The purinergic antagonist PPADS reduces pain related behaviours and interleukin‐1β, interleukin‐6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice

  2008cited by this paper
• Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.

  2008cited by this paper
• Matrix Metalloproteinase-9 Facilitates Glial Scar Formation in the Injured Spinal Cord

  2008cited by this paper
• No Evidence for Chronic Demyelination in Spared Axons after Spinal Cord Injury in a Mouse

  2008cited by this paper
• Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice.

  2008cited by this paper
• Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury

  2008cited by this paper
• STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

  2008cited by this paper
• Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

  2008cited by this paper
• Requirement of Myeloid Cells for Axon Regeneration

  2008cited by this paper
• Tail pinching-induced hindlimb movements are suppressed by clonidine in spinal cord injured mice.

  2008cited by this paper
• Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse.

  2008cited by this paper
• Effects of zileuton and montelukast in mouse experimental spinal cord injury

  2008cited by this paper
• Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry

  2008cited by this paper
• TGF-alpha increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice.

  2008cited by this paper
• Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice.

  2008cited by this paper
• Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL‐12 administration

  2008cited by this paper
• Early adaptive changes in chronic paraplegic mice: a model to study rapid health degradation after spinal cord injury

  2008cited by this paper
• Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord

  2007cited by this paper
• Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury

  2006cited by this paper
• V1 spinal neurons regulate the speed of vertebrate locomotor outputs

  2006cited by this paper
• Contribution of spinal 5‐HT1A and 5‐HT7 receptors to locomotor‐like movement induced by 8‐OH‐DPAT in spinal cord‐transected mice

  2006cited by this paper
• Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice.

  2004cited by this paper
• Role of EphA4 and EphrinB3 in Local Neuronal Circuits That Control Walking

  2003cited by this paper
• Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes

  2003cited by this paper
• CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury.

  1998cited by this paper

• Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders.

  2022cites this paper
• Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies: An Update

  2019cites this paper
• Thermomineral water promotes axonal sprouting but does not reduce glial scar formation in a mouse model of spinal cord injury

  2014cites this paper
• Bone marrow stromal stem cells transplantation in mice with acute spinal cord injury.

  2014cites this paper
• Air Gun Impactor—A Novel Model of Graded White Matter Spinal Cord Injury in Rodents

  2012cites this paper
• Effect of alpha-melanocyte stimulating hormone on locomotor recovery following spinal cord injury in mice: Role of serotonergic system.

  2011cites this paper
• ISOLAMENTO, CARATTERIZZAZIONE E TRAPIANTO IN UN MODELLO MURINO DI LESIONE SPINALE DI CELLULE UMANE DI LIQUIDO AMNIOTICO

  2011cites this paper
• The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish.

  2011cites this paper
• Regenerative Medicine for Neurological Disorders

  2010cites this paper