Design and biological evaluation of new platinum(II) complexes bearing ligands with DNA-targeting ability.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Inorganic Chemistry

• Publication date

  2014-11-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/ic502373nPMID 25402634
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interactions between anticancer trans-platinum compounds and proteins: crystal structures and ESI-MS spectra of two protein adducts of trans-(dimethylamino)(methylamino)dichloridoplatinum(II).

  2014cited by this paper
• Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand.

  2013cited by this paper
• Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents.

  2013cited by this paper
• Drug-DNA interactions and their study by UV-Visible, fluorescence spectroscopies and cyclic voltametry.

  2013cited by this paper
• Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.

  2012cited by this paper
• Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured.

  2012cited by this paper
• Synthesis and Biological Studies of Pyrazolyl‐Diamine PtII Complexes Containing Polyaromatic DNA‐Binding Groups

  2012cited by this paper
• Synthesis and photophysical evaluation of a pyridinium 4-amino-1,8-naphthalimide derivative that upon intercalation displays preference for AT-rich double-stranded DNA.

  2012cited by this paper
• Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

  2012cited by this paper
• Understanding how the platinum anticancer drug carboplatin works: From the bottle to the cell

  2012cited by this paper
• Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents.

  2012cited by this paper
• Naphthalimide-tagged ruthenium-arene anticancer complexes: combining coordination with intercalation

  2012cited by this paper
• Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

  2012cited by this paper
• Organometallic Anticancer Compounds

  2010cited by this paper
• Fast cleavage of a diselenide induced by a platinum(II)-methionine complex and its biological implications.

  2010cited by this paper
• The status of platinum anticancer drugs in the clinic and in clinical trials.

  2010cited by this paper
• Metal complexes in medicine with a focus on enzyme inhibition.

  2010cited by this paper
• Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(II) anticancer complexes.

  2009cited by this paper
• Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent.

  2009cited by this paper
• Methionine can favor DNA platination by trans-coordinated platinum antitumor drugs.

  2009cited by this paper
• Towards Antitumor Active trans-Platinum Compounds.

  2009cited by this paper
• Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characteri­zation, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

  2008cited by this paper
• Influence of (Hydroxymethyl)pyridine and Pyridine‐carboxylic Acids, in trans‐Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

  2008cited by this paper
• Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds.

  2008cited by this paper
• New trends for metal complexes with anticancer activity.

  2008cited by this paper
• The resurgence of platinum-based cancer chemotherapy

  2007cited by this paper
• New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin.

  2007cited by this paper
• Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands

  2007cited by this paper
• An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

  2007cited by this paper
• Cisplatin : chemistry and biochemistry of a leading anticancer drug

  2006cited by this paper
• Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology.

  2006cited by this paper
• Excimer emission induced by metal ion coordination in 1,8-naphthalimide-tethered iminopyridine ligands

  2003cited by this paper
• Antitumor and cellular pharmacological properties of a novel platinum(IV) complex: trans-[PtCl(2)(OH)(2)(dimethylamine) (isopropylamine)].

  2003cited by this paper
• Naphthalimides as anti-cancer agents: synthesis and biological activity.

  2001cited by this paper
• X-Ray structure of cytotoxic trans-[PtCl(2)(dimethylamine)(isopropylamine)]: interstrand cross-link efficiency, DNA sequence specificity, and inhibition of the B-Z transition.

  2000cited by this paper
• DNA binding studies and site selective fluorescence sensitization of an anthryl probe

  1993cited by this paper
• DNA unwinding produced by site-specific intrastrand cross-links of the antitumor drug cis-diamminedichloroplatinum(II).

  1991cited by this paper
• Unwinding of supercoiled DNA by cis- and trans-diamminedichloroplatinum(II): influence of the torsional strain on DNA unwinding.

  1985cited by this paper
• Ueber die Destillationsprodukte der Xanthogenate (Aethyldithiocarbonate)

  1877cited by this paper

• Palladium(II) Complexes with Noncovalent Interactions with DNA: Solution Speciation Controlled by Solvent Identity, pH, and Concentration

  2025cites this paper
• Synthetic routes and chemical structural analysis for guiding the strategies on new Pt(II) metallodrug design.

  2024cites this paper
• A review on the chemistry of novel platinum chelates based on azo-azomethine ligands

  2022cites this paper
• DNA‐Intercalative Platinum Anticancer Complexes Photoactivated by Visible Light

  2021cites this paper
• Synthesis, Characterization, and Anticancer Activity of Benzothiazole Aniline Derivatives and Their Platinum (II) Complexes as New Chemotherapy Agents

  2021cites this paper
• A kinetic investigation of mononuclear trans-platinum(II) complexes with mixed amine ligands

  2020cites this paper
• A Pt(IV)-based mononitro-naphthalimide conjugate with minimized side-effects targeting DNA damage response via a dual-DNA-damage approach to overcome cisplatin resistance.

  2020cites this paper
• Simple Trans-Platinum Complex Bearing 3-Aminoflavone Ligand Could Be a Useful Drug: Structure-Activity Relationship of Platinum Complex in Comparison with Cisplatin

  2020cites this paper
• Synthesis and biological evaluation of new mono naphthalimide platinum(IV) derivatives as antitumor agents with dual DNA damage mechanism

  2020cites this paper
• Versatile Route to trans-Platinum(II) Complexes via Manipulation of a Coordinated 3-(Pyridin-3-yl)propanoic Acid Ligand.

  2019cites this paper
• Enhancing Cytotoxicity of a Monofunctional Platinum Complex via a Dual-DNA-Damage Approach.

  2019cites this paper
• New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action

  2019cites this paper
• Metallodrugs and their various impacts on disorders and diseases

  2019cites this paper
• α-Diimine homologues of cisplatin: synthesis, speciation in DMSO/water and cytotoxicity

  2018cites this paper
• l,8-Naphthalimide based DNA intercalators and anticancer agents. A systematic review from 2007 to 2017.

  2018cites this paper
• Design and synthesis of a new series of low toxic naphthalimide platinum(IV) antitumor complexes with dual DNA damage mechanism

  2018cites this paper
• Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

  2018cites this paper
• Anticancer platinum‐based complexes with non‐classical structures

  2018cites this paper
• Naphthalimide Platinum(IV) Compounds as Antitumor Agents with Dual DNA Damage Mechanism to Overcome Cisplatin Resistance

  2018cites this paper
• Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands.

  2017cites this paper
• Anticancer activity of a trans-platinum(II) complex of 3-aminoflavone to ovarian cancer cells.

  2017cites this paper
• Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

  2017cites this paper
• New trends in platinum and palladium complexes as antineoplastic agents

  2016cites this paper
• Cr(3+) Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis.

  2016cites this paper
• Aquation Is a Crucial Activation Step for Anticancer Action of Ruthenium(II) Polypyridyl Complexes to Trigger Cancer Cell Apoptosis.

  2016cites this paper
• Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance.

  2015cites this paper
• Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates.

  2015cites this paper
• New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2'-bipyridine and 2,2'-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity.

  2015cites this paper
• Cationic Pd(II)/Pt(II) 5,5-diethylbarbiturate complexes with bis(2-pyridylmethyl)amine and terpyridine: Synthesis, structures,DNA/BSA interactions, intracellular distribution, cytotoxic activity and induction of apoptosis.

  2015cites this paper