miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Oncogene

• Publication date

  2014-07-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/onc.2013.330PMID 23934188PMCID PMC3922897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells

  2013cited by this paper
• miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells

  2013cited by this paper
• MiR-137 Targets Estrogen-Related Receptor Alpha and Impairs the Proliferative and Migratory Capacity of Breast Cancer Cells

  2012cited by this paper
• Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

  2012cited by this paper
• A Competitive Inhibitor That Reduces Recruitment of Androgen Receptor to Androgen-responsive Genes*

  2012cited by this paper
• DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs.

  2012cited by this paper
• Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines

  2012cited by this paper
• A statin-regulated microRNA represses human c-Myc expression and function

  2012cited by this paper
• Doxorubicin-induced in vivo nephrotoxicity involves oxidative stress-mediated multiple pro- and anti-apoptotic signaling pathways.

  2012cited by this paper
• Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR.

  2012cited by this paper
• miRNAs as mediators of drug resistance.

  2012cited by this paper
• Modulation of MicroRNAs by Chemical Carcinogens and Anticancer Drugs in Human Cancer: Potential Inkling to Therapeutic Advantage.

  2011cited by this paper
• Regulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells

  2011cited by this paper
• MicroRNA‐137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck

  2011cited by this paper
• Role of microRNAs in lymphoid biology and disease

  2011cited by this paper
• Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

  2011cited by this paper
• miR‐301a as an NF‐κB activator in pancreatic cancer cells

  2011cited by this paper
• miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42

  2011cited by this paper
• miR‐137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells

  2011cited by this paper
• Chromosomal and MicroRNA Expression Patterns Reveal Biologically Distinct Subgroups of 11q− Neuroblastoma

  2010cited by this paper
• MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index.

  2010cited by this paper
• Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.

  2010cited by this paper
• Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways.

  2010cited by this paper
• Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin.

  2010cited by this paper
• Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

  2010cited by this paper
• A Single Amino Acid Controls the Functional Switch of Human Constitutive Androstane Receptor (CAR) 1 to the Xenobiotic-Sensitive Splicing Variant CAR3

  2010cited by this paper
• Direct and Coordinate Regulation of ATP-binding Cassette Transporter Genes by Myc Factors Generates Specific Transcription Signatures That Significantly Affect the Chemoresistance Phenotype of Cancer Cells*

  2010cited by this paper
• Causes and consequences of microRNA dysregulation in cancer

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Widespread Dysregulation of MiRNAs by MYCN Amplification and Chromosomal Imbalances in Neuroblastoma: Association of miRNA Expression with Survival

  2009cited by this paper
• Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.

  2009cited by this paper
• The impact of microRNAs and alternative splicing in pharmacogenomics

  2009cited by this paper
• Simultaneous targeting of MCL1 and ABCB1 as a novel strategy to overcome drug resistance in human leukaemia

  2009cited by this paper
• Epigenetic regulation of microRNA expression in colorectal cancer

  2009cited by this paper
• Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.

  2009cited by this paper
• Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.

  2008cited by this paper
• ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

  2008cited by this paper
• Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells*

  2008cited by this paper
• MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.

  2008cited by this paper
• Quantitation of Doxorubicin Uptake, Efflux, and Modulation of Multidrug Resistance (MDR) in MDR Human Cancer Cells

  2008cited by this paper
• MicroRNAs modulate the chemosensitivity of tumor cells

  2008cited by this paper
• LNA-mediated microRNA silencing in non-human primates

  2008cited by this paper
• Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis.

  2007cited by this paper
• Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells.

  2007cited by this paper
• Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs.

  2007cited by this paper
• CpG island hypermethylation of tumor suppressor microRNAs in human cancer.

  2007cited by this paper
• CpG Island Hypermethylation of Tumor Suppressor microRNAs in Human Cancer

  2007cited by this paper
• Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor

  2006cited by this paper
• Oncomirs — microRNAs with a role in cancer

  2006cited by this paper
• Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

  2006cited by this paper
• Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells.

  2006cited by this paper
• Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas‐induced murine liver injury by altering Bcl‐2 proteins

  2006cited by this paper
• Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters.

  2005cited by this paper
• Real-time quantification of microRNAs by stem–loop RT–PCR

  2005cited by this paper
• Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.

  2005cited by this paper
• Silencing of microRNAs in vivo with ‘antagomirs’

  2005cited by this paper
• The functions of animal microRNAs

  2004cited by this paper
• MicroRNAs: small RNAs with a big role in gene regulation

  2004cited by this paper
• MicroRNAs: small RNAs with a big role in gene regulation

  2004cited by this paper
• DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

  2004cited by this paper
• MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma

  2004cited by this paper
• Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: A preclinical model

  2003cited by this paper
• Towards a complete description of the microRNA complement of animal genomes

  2003cited by this paper
• A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression*

  2003cited by this paper
• Neuroblastoma: biological insights into a clinical enigma

  2003cited by this paper
• Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR

  2002cited by this paper
• Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS.

  2002cited by this paper
• Safety of intravitreous fomivirsen for treatment of cytomegalovirus retinitis in patients with AIDS

  2002cited by this paper
• The fundamental role of epigenetic events in cancer

  2002cited by this paper
• Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

  2000cited by this paper
• Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin.

  1999cited by this paper
• Long‐term productive human cytomegalovirus infection of a human neuroblastoma cell line

  1996cited by this paper
• Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells.

  1996cited by this paper
• Flow cytometric studies on modulation of cellular adriamycin retention by phenothiazines.

  1985cited by this paper
• Laser flow cytometric studies on the intracellular fluorescence of anthracyclines.

  1980cited by this paper

• Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis

  2025cites this paper
• MiRNAs: main players of cancer drug resistance target ABC transporters

  2025cites this paper
• MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters

  2024cites this paper
• Advances in drug resistance of osteosarcoma caused by pregnane X receptor

  2024cites this paper
• Extracellular vesicles in neuroblastoma: role in progression, resistance to therapy and diagnostics

  2024cites this paper
• Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming.

  2023cites this paper
• Therapy resistance in neuroblastoma: Mechanisms and reversal strategies

  2023cites this paper
• From resistance to resilience: Uncovering chemotherapeutic resistance mechanisms; insights from established models.

  2023cites this paper
• Role of non-coding RNAs in neuroblastoma

  2023influential citation
• Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance

  2022cites this paper
• MicroRNA as a Potential Therapeutic Molecule in Cancer

  2022cites this paper
• Clinical implications of noncoding RNAs in neuroblastoma patients

  2022cites this paper
• Regulation of drug transporters by microRNA and implications in disease treatment

  2021cites this paper
• University of and the creation of a tumour-conducive microenvironment in neuroblastoma

  2021cites this paper
• The role of non-coding RNAs in chemotherapy for gastrointestinal cancers

  2021cites this paper
• Regulation of drug transporters by microRNA and implications in disease treatment

  2021cites this paper
• The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update

  2021cites this paper
• Genomic Instability in Multiple Myeloma: A “Non-Coding RNA” Perspective

  2021cites this paper
• RETRACTED ARTICLE: The role of miRNAs and lncRNAs in conferring resistance to doxorubicin

  2021cites this paper
• Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

  2020cites this paper
• Intra-tumoral drug concentration mapping within solid tumor micro-milieu using in-vitro model and doxorubicin as a model drug

  2020cites this paper
• Genetic and epigenetic modulation of drug resistance in cancer: Challenges and opportunities.

  2020cites this paper
• miR-137: A Novel Therapeutic Target for Human Glioma

  2020cites this paper
• Regulation of CAR and PXR Expression in Health and Disease

  2020cites this paper
• The Differential DNA Hypermethylation Patterns of microRNA-137 and microRNA-342 Locus in Early Colorectal Lesions and Tumours

  2019cites this paper
• Current Challenges in the Management of Neuroblastoma

  2019cites this paper
• MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5.

  2019cites this paper
• OTT_A_228199 11057..11068

  2019cites this paper
• Knockdown Of lncRNA NCK-AS1 Regulates Cisplatin Resistance Through Modulating miR-137 In Osteosarcoma Cells

  2019cites this paper
• MicroRNA dysregulation interplay with childhood abdominal tumors

  2019cites this paper
• MicroRNAs in neuroblastoma tumorigenesis, therapy resistance, and disease evolution

  2019influential citation
• MicroRNA Mediated Changes in Drug Metabolism and Target Gene Expression by Efavirenz and Rifampicin In Vitro: Clinical Implications

  2019cites this paper
• Combinational strategy for high-performance cancer chemotherapy.

  2018cites this paper
• A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders

  2018cites this paper
• Methylation of DNA and chromatin as a mechanism of oncogenesis and therapeutic target in neuroblastoma

  2018cites this paper
• The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

  2018cites this paper
• Structure and Function of Multidrug Resistance Protein 1

  2018cites this paper
• Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation

  2018cites this paper
• HEPATIC XENOBIOTIC RECEPTORS IN THE UBIQUITIN-PROTEASOME SYSTEM

  2018cites this paper
• Epigenetic regulation of drug transporter expression in human tissues

  2017cites this paper
• Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System

  2017cites this paper
• Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR‐137

  2017influential citation
• Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myeloma

  2017cites this paper
• Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

  2017cites this paper
• MiRNA-124-3p Reduces Cell Viability in Cisplatin Resistant Neuroblastoma Cell Models.

  2017cites this paper
• The orphan nuclear receptor NR4A2 is part of a p53–microRNA-34 network

  2016cites this paper
• Pregnane X receptor and constitutive androstane receptor activation by non-nucleoside HIV-1 reverse transcriptase inhibitors

  2016cites this paper
• microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP

  2016cites this paper
• Bioinformatic analysis of microRNA networks following the activation of the constitutive androstane receptor (CAR) in mouse liver.

  2016cites this paper
• Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.

  2016cites this paper
• Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells

  2016cites this paper
• Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence

  2016influential citation
• Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade.

  2016cites this paper
• Hurdles in selection process of nanodelivery systems for multidrug-resistant cancer

  2016cites this paper
• miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1

  2016cites this paper
• Role of nuclear constitutive androstane receptor in regulation of hepatocyte proliferation and hepatocarcinogenesis

  2016cites this paper
• MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy

  2016cites this paper
• Bile Acids as Novel Pharmacological Agents: The Interplay Between Gene Polymorphisms, Epigenetic Factors and Drug Response.

  2016cites this paper
• Towards diagnostic application of non-coding RNAs in neuroblastoma

  2016cites this paper
• A feedback expression of microRNA-590 and activating transcription factor-3 in human breast cancer cells.

  2015cites this paper
• The Regulation of Musashi RNA Binding Proteins and the Implications for Cancer Therapy

  2015cites this paper
• MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators

  2015cites this paper
• Linear polyethyleneimine-doxorubicin conjugate for pH-responsive synchronous delivery of drug and microRNA-34a

  2015cites this paper
• Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

  2015cites this paper
• CINPA1 Is an Inhibitor of Constitutive Androstane Receptor That Does Not Activate Pregnane X Receptor

  2015influential citation
• MiR-218 inhibits multidrug resistance (MDR) of gastric cancer cells by targeting Hedgehog/smoothened.

  2015cites this paper
• microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18.

  2015cites this paper
• MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors

  2015cites this paper
• CINPA 1 Is an Inhibitor of Constitutive Androstane Receptor That Does Not Activate Pregnane X Receptor s

  2015cites this paper
• Microsoft Word-46772571-file00.docx

  2015cites this paper
• microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.

  2015cites this paper
• MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC)

  2015cites this paper
• The Roles of Two miRNAs in Regulating the Immune Response of Sea Cucumber

  2015cites this paper
• A food contaminant ochratoxin A suppresses pregnane X receptor (PXR)-mediated CYP3A4 induction in primary cultures of human hepatocytes.

  2015cites this paper
• MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel

  2014cites this paper
• microRNA Expression Pattern Modulates Temozolomide Response in GBM Tumors with Cancer Stem Cells

  2014cites this paper
• MicroRNAs: master regulators of drug resistance, stemness, and metastasis

  2014cites this paper
• Post-transcriptional regulation by miR-137 underlies the low abundance of CAR and low rate of bilirubin clearance in neonatal mice.

  2014cites this paper
• MicroRNAs in cancer therapeutic response: Friend and foe.

  2014cites this paper
• Deciphering the roles of the constitutive androstane receptor in energy metabolism

  2014cites this paper
• Optimization of reconstituted high density lipoprotein nanoparticles as a delivery system for neuroblastoma treatment

  2013cites this paper