Novelty seeking is characteristic of ADHD, but how this influences reward-related decision-making is unknown. Sethi et al. show that stimulant medication selectively attenuates ADHD participants’ tendency to repeatedly select non-optimal novel options, and reduces substantia nigra novelty signalling. Stimulant medication increases learning rates and enhances performance in ADHD participants compared to effects in controls.
A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder
Arjun Sethi,V. Voon,H. Critchley,M. Cercignani,N. Harrison
Published 2018 in Brain : a journal of neurology
ABSTRACT
PUBLICATION RECORD
- Publication year
2018
- Venue
Brain : a journal of neurology
- Publication date
2018-03-13
- Fields of study
Medicine, Psychology
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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