A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder

Arjun Sethi,V. Voon,H. Critchley,M. Cercignani,N. Harrison

Published 2018 in Brain : a journal of neurology

ABSTRACT

Novelty seeking is characteristic of ADHD, but how this influences reward-related decision-making is unknown. Sethi et al. show that stimulant medication selectively attenuates ADHD participants’ tendency to repeatedly select non-optimal novel options, and reduces substantia nigra novelty signalling. Stimulant medication increases learning rates and enhances performance in ADHD participants compared to effects in controls.

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