Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.181.9.6255PMID 18941216PMCID PMC2598777
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evolutionarily conserved amino acids that control TCR-MHC interaction.

  2008cited by this paper
• Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.

  2008cited by this paper
• Conformational flexibility and kinetic complexity in antibody–antigen interactions

  2008cited by this paper
• T-cell allorecognition: a case of mistaken identity or déjà vu?

  2008cited by this paper
• The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.

  2008cited by this paper
• Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon'

  2007cited by this paper
• High-Affinity TCRs Generated by Phage Display Provide CD4+ T Cells with the Ability to Recognize and Kill Tumor Cell Lines1

  2007cited by this paper
• How much can a T‐cell antigen receptor adapt to structurally distinct antigenic peptides?

  2007cited by this paper
• How a single T cell receptor recognizes both self and foreign MHC.

  2007influential reference
• Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.

  2006cited by this paper
• The Study of High-Affinity TCRs Reveals Duality in T Cell Recognition of Antigen: Specificity and Degeneracy1

  2006influential reference
• Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld.

  2006cited by this paper
• Engineering and Characterization of a Stabilized α1/α2 Module of the Class I Major Histocompatibility Complex Product Ld*

  2006cited by this paper
• How TCRs bind MHCs, peptides, and coreceptors.

  2006cited by this paper
• Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

  2006cited by this paper
• Unraveling a hotspot for TCR recognition on HLA-A2: evidence against the existence of peptide-independent TCR binding determinants.

  2005cited by this paper
• Structure of a human autoimmune TCR bound to a myelin basic protein self‐peptide and a multiple sclerosis‐associated MHC class II molecule

  2005influential reference
• Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function.

  2005cited by this paper
• The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

  2005cited by this paper
• Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand.

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004influential reference
• T cell receptor crossreactivity as a general property of T cell recognition.

  2004cited by this paper
• CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

  2004influential reference
• T Cell Cross-Reactivity and Conformational Changes during TCR Engagement

  2004cited by this paper
• Specificity and degeneracy of T cells.

  2004cited by this paper
• Protein dynamics and the immunological evolution of molecular recognition.

  2004cited by this paper
• T cell killing does not require the formation of a stable mature immunological synapse

  2004influential reference
• Positive and negative selection of T cells.

  2003cited by this paper
• TCRs with high affinity for foreign pMHC show self-reactivity

  2003influential reference
• A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

  2003cited by this paper
• CDR3 loop flexibility contributes to the degeneracy of TCR recognition

  2003cited by this paper
• Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation.

  2003cited by this paper
• A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.

  2003cited by this paper
• A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.

  2002cited by this paper
• Pushing the boundaries of molecular replacement with maximum likelihood.

  2001cited by this paper
• Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation

  2001cited by this paper
• Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis

  2001cited by this paper
• Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.

  2001cited by this paper
• Role of 2c T Cell Receptor Residues in the Binding of Self–And Allo–Major Histocompatibility Complexes

  2000cited by this paper
• In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

  2000cited by this paper
• Breaking the affinity ceiling for antibodies and T cell receptors.

  2000cited by this paper
• Directed evolution of a stable scaffold for T-cell receptor engineering

  2000cited by this paper
• Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

  2000cited by this paper
• A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.

  2000cited by this paper
• Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning.

  1999cited by this paper
• TCR binding to peptide-MHC stabilizes a flexible recognition interface.

  1999cited by this paper
• Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor

  1999cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Ligand recognition by alpha beta T cell receptors.

  1998cited by this paper
• Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.

  1998cited by this paper
• Alanine Scanning Mutagenesis of an αβ T Cell Receptor: Mapping the Energy of Antigen Recognition

  1998cited by this paper
• Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition.

  1998cited by this paper
• LIGAND RECOGNITION BY T CELL RECEPTORS

  1998cited by this paper
• A very high level of crossreactivity is an essential feature of the T-cell receptor.

  1998cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.

  1997cited by this paper
• Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

  1996cited by this paper
• Kinetic and affinity limits on antibodies produced during immune responses.

  1995cited by this paper
• High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

  1994cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

  1993cited by this paper
• Stereochemical quality of protein structure coordinates

  1992cited by this paper
• HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

  1992cited by this paper
• T-cell antigen receptor genes and T-cell recognition

  1988cited by this paper
• Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

  1984cited by this paper

• TCRCluster: a novel approach to T-cell receptor latent featurization and clustering using contrastive learning-guided two-stage variational autoencoders

  2025cites this paper
• Disrupting explicit encoding paradigms: property-interactive transformers decode T-cell receptor specificity beyond dataset biases

  2025cites this paper
• Application of phage display for T-cell receptor discovery.

  2021cites this paper
• Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires

  2021cites this paper
• Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells

  2021cites this paper
• Construction and evaluation of an antibody phage display library targeting heparan sulfate

  2020cites this paper
• The discriminatory power of the T cell receptor

  2020cites this paper
• Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

  2020cites this paper
• MHC Restriction: Where Are We Now?

  2020cites this paper
• Exploring the different states of wild-type T-cell receptor and mutant conformational changes towards understanding the antigen recognition

  2019cites this paper
• Structure-Guided T Cell Receptor Mutations that Alter Antigen Specificity, Cross-Reactivity, and Polyfunctional Phenotypes in Gene-Modified T Cells

  2019cites this paper
• T cell receptor cross-reactivity expanded by dramatic peptide/MHC adaptability

  2018cites this paper
• An Examination of MHC, Peptide, and TCR Interactions

  2018cites this paper
• Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity

  2017cites this paper
• Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes

  2017cites this paper
• A unifying mathematical framework for experimental TCR-pMHC kinetic constants

  2017cites this paper
• DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles

  2017cites this paper
• Generation of TCRs of higher affinity by antigen-driven differentiation of progenitor T cells in vitro

  2017cites this paper
• Anti-CMV CD8+ T-cell epitope specificities and T-cell receptor repertoires in African study subjects

  2017cites this paper
• Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity

  2016cites this paper
• Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice

  2015cites this paper
• TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity.

  2015cites this paper
• Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition

  2015influential citation
• Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity

  2015cites this paper
• Molecular description of how MART-1 specific T-cell receptors recognize structurally diverse melanoma antigens

  2013cites this paper
• Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes.

  2013cites this paper
• Role of T Cell Receptor Affinity in the Efficacy and Specificity of Adoptive T Cell Therapies

  2013influential citation
• This information is current as Structure and Molecular Dynamics MHC Class I Molecules : Insight from The Peptide-Receptive Transition State of

  2012cites this paper
• Unexpected T‐cell recognition of an altered peptide ligand is driven by reversed thermodynamics

  2012cites this paper
• T cell receptor engineering.

  2012cites this paper
• Reconciling views on T cell receptor germline bias for MHC.

  2012cites this paper
• Diversity‐oriented approaches for interrogating T‐cell receptor repertoire, ligand recognition, and function

  2012cites this paper
• Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex

  2012cites this paper
• The influences of conformational dynamics on T cell receptor specificity and cross-reactivity

  2012cites this paper
• The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular Dynamics

  2012cites this paper
• T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.

  2011cites this paper
• Interaction of Streptavidin-Based Peptide-MHC Oligomers (Tetramers) with Cell-Surface T Cell Receptors

  2011cites this paper
• The effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.

  2011cites this paper
• Cell-Surface TCRs MHC Oligomers (Tetramers) with - Interaction of Streptavidin-Based Peptide

  2011cites this paper
• Interaction of Streptavidin-Based Peptide–MHC Oligomers (Tetramers) with Cell-Surface TCRs

  2011cites this paper
• Absence of CD8 Class I on T Cell Activity in the Presence and MHC - Opposite Effects of Endogenous Peptide

  2011cites this paper
• Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism.

  2011cites this paper
• Opposite Effects of Endogenous Peptide–MHC Class I on T Cell Activity in the Presence and Absence of CD8

  2011cites this paper
• Engineering human single-chain T cell receptors

  2010cites this paper
• This information is current as High-Affinity Noncognate Ligands CD 8 on T Cell Activation Induced by Cutting Edge : Inhibitory Effects of CD 4 and and

  2009cites this paper
• Different Strategies Adopted by Kb and Ld to Generate T Cell Specificity Directed against Their Respective Bound Peptides*

  2009cites this paper
• Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands1

  2009cites this paper
• T‐cell receptor binding affinities and kinetics: impact on T‐cell activity and specificity

  2009cites this paper
• The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness1

  2009cites this paper
• Many different Vβ CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions

  2009cites this paper
• Grading the commercial optical biosensor literature—Class of 2008: ‘The Mighty Binders’

  2009cites this paper
• ResponsivenessAntigen Presentation Format on T Cell The Impact of TCR-Binding Properties and

  2009cites this paper
• The molecular basis of TCR germline bias for MHC is surprisingly simple

  2009cites this paper
• Functional implications of T cell receptor diversity.

  2009cites this paper
• Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors.

  2008cites this paper
• Engineering higher affinity T cell receptors using a T cell display system.

  2008cites this paper
• Analysis of specific TCR : pMHC structures : Detailed discussion for the individual TCR types

  year unknowncites this paper
• S5 Table. References to the Tcr Structures Used for the Analysis Name Pdb Ref. Name Pdb Ref

  year unknowncites this paper