Antithrombin is as effective as heparin and hirudin to prevent formation of microvascular thrombosis in a murine model

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Thrombosis and Haemostasis

• Publication date

  2006-08-11

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1160/TH06-02-0118PMID 16953281
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Benefit/risk profile of high-dose antithrombin in patients with severe sepsis treated with and without concomitant heparin

  2006cited by this paper
• Coagulation in sepsis

  2004cited by this paper
• Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1

  2004cited by this paper
• Coagulopathy of sepsis

  2004cited by this paper
• Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

  2004cited by this paper
• New treatment strategies for disseminated intravascular coagulation based on current understanding of the pathophysiology

  2004cited by this paper
• Intravascular tissue factor pathway – a model for rapid initiation of coagulation within the blood vessel

  2003cited by this paper
• Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production.

  2003cited by this paper
• Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse.

  2003cited by this paper
• Adverse Effect of Heparin on Antithrombin Action during Endotoxemia: Microhemodynamic and Cellular Mechanisms

  2002cited by this paper
• Antithrombin: a new look at the actions of a serine protease inhibitor

  2002cited by this paper
• Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats.

  2002cited by this paper
• Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium

  2002influential reference
• Treating sepsis.

  2002cited by this paper
• Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: A multicenter, randomized, placebo-controlled, single-blind, dose escalation study

  2001cited by this paper
• Endogenous Nitric Oxide and Prostaglandins Synergistically Counteract Thromboembolism in Arterioles but Not in Venules

  2001cited by this paper
• Epidemiology of sepsis: An update

  2001cited by this paper
• Hirudin versus heparin for anticoagulation in continuous renal replacement therapy

  2001cited by this paper
• Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial.

  2001cited by this paper
• Probing inhibitor-induced conformational changes along the interface between tissue factor and factor VIIa.

  2001cited by this paper
• The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure.

  2000cited by this paper
• Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway.

  2000cited by this paper
• Pharmacokinetics of Recombinant Transgenic Antithrombin in Volunteers

  2000cited by this paper
• Pathophysiology of disseminated intravascular coagulation in sepsis.

  2000cited by this paper
• In vivo analysis of antithrombotic effectiveness of recombinant hirudin on microvascular thrombus formation and recanalization.

  1998influential reference
• Antithrombin prevents endotoxin-induced pulmonary vascular injury by inhibiting leukocyte activation.

  1998cited by this paper
• Antithrombin: Its Physiological Importance and Role in DIC

  1998cited by this paper
• Antithrombin III in Animal Models of Sepsis and Organ Failure

  1998cited by this paper
• ATTENUATION OF ENDOTOXIN‐INDUCED PULMONARY VASCULAR INJURY BY ANTITHROMBIN III.: 653

  1997cited by this paper
• A New Model for Quantitative In Vivo Microscopic Analysis of Thrombus Formation and Vascular Recanalisation: The Ear of the Hairless (hr/hr) Mouse

  1997influential reference
• Importance of photo activation of rose bengal for platelet activation in experimental models of photochemically induced thrombosis.

  1996cited by this paper
• Regulation of tissue factor gene expression in human monocytic and endothelial cells.

  1996cited by this paper
• Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III

  1996cited by this paper
• Coagulation inhibitor substitution during sepsis

  1995cited by this paper
• Guidelines for the use of innovative therapies in sepsis.

  1993cited by this paper
• Pharmacology of r-hirudin in renal impairment.

  1992cited by this paper
• American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis

  1992cited by this paper
• Rapid leukocyte accumulation by "spontaneous" rolling and adhesion in the exteriorized rabbit mesentery.

  1991cited by this paper
• Heparin-like glycosaminoglycan is a receptor for antithrombin III-dependent but not for thrombin-dependent prostacyclin production in human endothelial cells.

  1990cited by this paper
• Protection against disseminated intravascular coagulation and death by antithrombin-III in the Escherichia coli endotoxemic rat.

  1987cited by this paper
• Antithrombin III: Biodistribution in Healthy Volunteers

  1987cited by this paper
• PHOTOMODIFICATION OF BIOLOGICAL MEMBRANES WITH EMPHASIS ON SINGLET OXYGEN MECHANISMS

  1987cited by this paper
• Effects of Human Antithrombin III on Mortality and Blood Coagulation Induced in Rabbits by Endotoxin

  1984cited by this paper
• Clinical Pharmacokinetics of Heparin

  1980cited by this paper

• Mouse laser injury models: variations on a theme

  2020cites this paper
• The effects of hydrogen sulfide on platelet–leukocyte aggregation and microvascular thrombolysis

  2017cites this paper
• Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse.

  2017cites this paper
• Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation

  2015cites this paper
• Roles of Coagulation and Fibrinolysis in Angiotensin II‐Enhanced Microvascular Thrombosis

  2014cites this paper
• Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice

  2014cites this paper
• The thrombolytic action of a proteolytic fraction (P1G10) from Carica candamarcensis.

  2013cites this paper
• Cross-modulatory effects of clopidogrel and heparin on platelet and fibrin incorporation in thrombosis

  2013cites this paper
• Antithrombin Reduces Inflammation and Microcirculatory Perfusion Failure in Closed Soft-Tissue Injury and Endotoxemia

  2013cites this paper
• Anticoagulative strategies in reconstructive surgery – clinical significance and applicability

  2012cites this paper
• Antithrombin therapy in pancreas retransplantation and pancreas‐after‐kidney/pancreas‐transplantation‐alone patients

  2011cites this paper
• Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.

  2011cites this paper
• A ferric chloride induced arterial injury model used as haemostatic effect model

  2010cites this paper
• Comparison of recombinant and plasma-derived antithrombin biodistribution in a rabbit model

  2009cites this paper
• Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients

  2009cites this paper
• Thrombin mediates the extraintestinal thrombosis associated with experimental colitis.

  2008cites this paper
• GI-90400-2008 R-1-Thrombin mediates the extra-intestinal thrombosis associated with experimental colitis

  2008cites this paper
• Efficacy of antithrombin in the prevention of microvascular thrombosis during endotoxemia: an intravital microscopic study.

  2007cites this paper
• Murine Models of Vascular Thrombosis

  2007cites this paper
• Regulation of Hemostasis and Thrombosis Insights from Murine Models

  2007cites this paper
• HEMORRHAGE PROGRESSIVELY DISTURBS INTERALVEOLAR PERFUSION IN THE LUNGS OF RATS

  2007cites this paper
• Bibliography of current world literature.

  2007cites this paper
• Murine models of vascular thrombosis (Eitzman series).

  2007cites this paper
• Lokaler Hitzeschock - Ein Konditionierungsverfahren zur Reduktion der inflammatorischen Antwort und zur Verbesserung der mikrovaskulären Perfusion in transferierten osteomyokutanen Lappen

  2006cites this paper