Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling

G protein–coupled receptor CRHR1 activates both soluble adenylyl cyclase (sAC) and transmembrane adenylyl cyclases. Here, Inda et al. show that only sAC activity is essential for internalization-dependent cAMP and sustained ERK1/2 activation responses, revealing a functional association between sAC-generated cAMP and endosome-based G protein–coupled receptor signaling.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-07-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1083/jcb.201512075PMID 27402953PMCID 4949449
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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