Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis

Concentrating factors in nuclear bodies is thought to promote efficient gene expression. Tatomer et al. show that the histone locus body (HLB) concentrates pre-mRNA processing factors at replication-dependent histone genes, resulting in optimal 3′ end formation of histone mRNAs coupled with transcription termination.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-06-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201504043PMID 27241916PMCID 4896052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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