Neuronal Overexpression of Heme Oxygenase‐1 Correlates with an Attenuated Exploratory Behavior and Causes an Increase in Neuronal NADPH Diaphorase Staining

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Neurochemistry

• Publication date

  1998-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.1998.70052057.xPMID 9572292
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitric oxide

  2021influential reference
• messenger

  2008cited by this paper
• Function and induction of the microsomal heme oxygenase

  2004cited by this paper
• The heme oxygenase system: a regulator of second messenger gases.

  1997cited by this paper
• Distribution of Brain-Derived Neurotrophic Factor (BDNF) Protein and mRNA in the Normal Adult Rat CNS: Evidence for Anterograde Axonal Transport

  1997cited by this paper
• Sexually dimorphic effects of anti-NGF treatment in neonatal rats.

  1997influential reference
• Induction of Heme Oxygenase-1 Expression in Vascular Smooth Muscle Cells

  1997cited by this paper
• Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans-Isomerase Activity

  1997cited by this paper
• Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells.

  1997cited by this paper
• Gas-generating systems in acute renal allograft rejection in the rat. Co-induction of heme oxygenase and nitric oxide synthase.

  1996cited by this paper
• NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium.

  1996cited by this paper
• Apoptosis induced by β-N-oxalylamino-l-alanine on a motoneuron hybrid cell line

  1996cited by this paper
• Long‐term Induction of Haem Oxygenase‐1 (HSP‐32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

  1996cited by this paper
• Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis*

  1996cited by this paper
• Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees.

  1996cited by this paper
• Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage.

  1996cited by this paper
• Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease.

  1996cited by this paper
• Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter.

  1996cited by this paper
• Stress response of the rat testis: in situ hydridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia.

  1996cited by this paper
• Animal behavioral methods in neurotoxicity assessment: SGOMSEC joint report.

  1996cited by this paper
• Apoptosis induced by beta-N-oxalylamino-L-alanine on a motoneuron hybrid cell line.

  1996cited by this paper
• Corticosterone Has a Permissive Effect on Expression of Heme Oxygenase‐1 in CA1–CA3 Neurons of Hippocampus in Thermal‐Stressed Rats

  1995cited by this paper
• Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.

  1995cited by this paper
• Ultrastructural localization of heme oxygenase-1 to the neurofibrillary pathology of Alzheimer disease.

  1995cited by this paper
• Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stress.

  1995cited by this paper
• Direct demonstration of a physiological role for carbon monoxide in olfactory receptor neurons

  1995cited by this paper
• Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells.

  1995cited by this paper
• Destruction of the cholinergic basal forebrain using immunotoxin to rat NGF receptor: modeling the cholinergic degeneration of Alzheimer's disease.

  1995cited by this paper
• Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

  1994cited by this paper
• Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate.

  1994cited by this paper
• Iron regulates nitric oxide synthase activity by controlling nuclear transcription

  1994cited by this paper
• Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.

  1994cited by this paper
• Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation.

  1994cited by this paper
• Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

  1994cited by this paper
• Reduction of depolarization-induced glutamate release by heme oxygenase inhibitor: possible role of carbon monoxide in synaptic transmission.

  1994cited by this paper
• The effects general and restricted serotonergic lesions on hippocampal electrophysiology and behavior

  1994cited by this paper
• Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

  1994cited by this paper
• Carbon Monoxide: An Emerging Regulator of cGMP in the Brain.

  1993cited by this paper
• Targeted disruption of the neuronal nitric oxide synthase gene.

  1993cited by this paper
• A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative.

  1993cited by this paper
• Serotonergic innervation of the mature and developing lateral septum of the rat: a light and electron microscopic immunocytochemical analysis.

  1993cited by this paper
• Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids.

  1993cited by this paper
• Learning to modulate transmitter release: themes and variations in synaptic plasticity.

  1993cited by this paper
• Clomipramine increases firing rate in lateral septal neurons related with hippocampus.

  1993cited by this paper
• Carbon monoxide: a putative neural messenger.

  1993cited by this paper
• Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus.

  1993cited by this paper
• Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin.

  1993cited by this paper
• Reversal of long-term potentiation by inhibitors of haem oxygenase

  1993cited by this paper
• Heme Oxygenase

  1992cited by this paper
• Normal and Heat‐Induced Patterns of Expression of Heme Oxygenase‐1 (HSP32) in Rat Brain: Hyperthermia Causes Rapid Induction of mRNA and Protein

  1992cited by this paper
• Distribution of nerve growth factor‐like immunoreactive neurons in the adult rat brain following colchicine treatment

  1992cited by this paper
• In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2.

  1992cited by this paper
• Histochemical mapping of nitric oxide synthase in the rat brain.

  1992cited by this paper
• Nitric oxide, a novel neuronal messenger.

  1992cited by this paper
• A novel neuronal messenger molecule in brain: The free radical, nitric oxide

  1992cited by this paper
• Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light.

  1991cited by this paper
• Neuronal NADPH diaphorase is a nitric oxide synthase.

  1991cited by this paper
• Nitric oxide: physiology, pathophysiology, and pharmacology.

  1991cited by this paper
• Role of nitric oxide synthesis in macrophage antimicrobial activity.

  1991cited by this paper
• Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

  1991cited by this paper
• Does carbon monoxide have a physiological function?

  1991cited by this paper
• Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases

  1991cited by this paper
• Short protocols in molecular biology

  1990cited by this paper
• Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion.

  1990cited by this paper
• Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control.

  1990cited by this paper
• Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

  1990cited by this paper
• Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

  1990cited by this paper
• Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis.

  1989cited by this paper
• Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium

  1989cited by this paper
• Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells.

  1989cited by this paper
• Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

  1989cited by this paper
• The functional anatomy of basal ganglia disorders.

  1989cited by this paper
• Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit.

  1989cited by this paper
• Bilirubin is an antioxidant of possible physiological importance.

  1987cited by this paper
• Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

  1987cited by this paper
• Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

  1986cited by this paper
• Cyclic guanosine monophosphate as a mediator of vasodilation.

  1986influential reference
• Cloning and expression of cDNA for rat heme oxygenase.

  1985cited by this paper
• Prenatal and postnatal development of retinogeniculate and retinocollicular projections in the mouse

  1984cited by this paper
• Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat.

  1981cited by this paper
• Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

  1981cited by this paper
• Behavioral effects of carbon monoxide on animals and man.

  1979cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• Human spleen heme oxygenase and microsomal electron transport system component activity in normals and in patients with hemolytic anemia, idiopathic thrombocytopenic purpura, and lymphoproliferative disorders.

  1979cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Turning behavior induced by electrical stimulation of the nigro-neostriatal system of the rat.

  1975cited by this paper
• The Action of Carbonic Oxide on Man

  1895cited by this paper

• The sinister face of heme oxygenase-1 in brain aging and disease.

  2019cites this paper
• Organo-Sulphur Garlic Compounds Influence Viability of Mammalian Cells: A Review

  2018cites this paper
• Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.

  2017cites this paper
• MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression.

  2015cites this paper
• A Heme Oxygenase-1 Transducer Model of Degenerative and Developmental Brain Disorders

  2015cites this paper
• Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases.

  2014cites this paper
• Neuroendocrinology of Hydromineral Homeostasis

  2014cites this paper
• Overexpression of Heme Oxygenase 1 Causes Cognitive Decline and Affects Pathways for Tauopathy in Mice

  2014cites this paper
• The role of chaperone proteins in neurodegenerative diseases

  2013cites this paper
• Mechanisms of immune evasion by gliomas.

  2012cites this paper
• In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice

  2012cites this paper
• Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms.

  2012cites this paper
• A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson's disease

  2011cites this paper
• Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells

  2010cites this paper
• Heme oxygenase‐1 and neurodegeneration: expanding frontiers of engagement

  2009cites this paper
• Regulation of haeme oxygenase‐1 for treatment of neuroinflammation and brain disorders

  2008cites this paper
• Estudos da cinética do antimônio e alterações de ci tocromos P450 hepáticos em primatas e ratos tratados com antimoniato de meglumina

  2008cites this paper
• HEME DEGRADATION IN ACUTE BRAIN INJURY: BENEFICIAL OR DETRIMENTAL TO RECOVERY?

  2007cites this paper
• Astroglia overexpressing heme oxygenase‐1 predispose co‐cultured PC12 cells to oxidative injury

  2007influential citation
• Reduced HO-1 Protein Expression is Associated with More Severe Neurodegeneration after Transient Ischemia Induced by Cortical Compression in Diabetic Goto—Kakizaki Rats

  2007cites this paper
• Induction of Heme Oxygenase-1 Is Involved in CO Mediated Central Cardiovascular Regulation

  2006influential citation
• Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury.

  2006cites this paper
• Over‐expression of heme oxygenase‐1 promotes oxidative mitochondrial damage in rat astroglia

  2006cites this paper
• Induction of Heme Oxygenase-1 Is Involved in Carbon Monoxide-Mediated Central Cardiovascular Regulation

  2006cites this paper
• Heme oxygenase expression in human central nervous system disorders.

  2004cites this paper
• Generation of Heme Oxygenase-1-Transgenic Rats

  2003cites this paper
• Glial heme oxygenase-1 in CNSinjury and disease

  2003cites this paper
• Heme Oxygenase-1 and Alzheimer Disease

  2002cites this paper
• Heme oxygenase 1 transgenic mice as a model to study neuroprotection.

  2002cites this paper
• HEME OXYGENASE-l AND ALZHEIMER DISEASE

  2002cites this paper
• Site of injury‐directed induction of heme oxygenase‐1 and ‐2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?

  2001cites this paper
• Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis.

  2000cites this paper
• MPTP selectively induces haem oxygenase‐1 expression in striatal astrocytes

  2000cites this paper
• List of transgenic and knockout mice: behavioral profiles

  2000cites this paper
• Neurons Overexpressing Heme Oxygenase‐1 Resist Oxidative Stress‐Mediated Cell Death

  2000cites this paper
• The heme oxygenase system and its functions in the brain.

  2000cites this paper
• Ironing-Out Mechanisms of Neuronal Injury under Hypoxic–Ischemic Conditions and Potential Role of Iron Chelators as Neuroprotective Agents

  2000cites this paper
• Roles of NMDA receptor activity and nitric oxide production in brain development.

  2000cites this paper
• Induction of heme oxygenase-1 in the rat brain by kainic acid-mediated excitotoxicity: the dissociation of mRNA and protein expression in hippocampus.

  1999cites this paper
• Overexpression of Heme Oxygenase‐1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

  1999influential citation
• Carbon monoxide and vascular cell function (review).

  1998cites this paper
• Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1.

  1998cites this paper