Teratogen-induced eye defects mediated by p53-dependent apoptosis.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Current Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0960-9822(02)00422-0PMID 8805222
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A subset of p53-deficient embryos exhibit exencephaly

  1995cited by this paper
• An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.

  1995cited by this paper
• Demonstration of DNA damage/repair in individual cells using in situ end labelling: Association of p53 with sites of DNA damage

  1995cited by this paper
• Programmed cell death and N-acetoxy-2-acetylaminofluorene-induced apoptosis in the rat embryo.

  1995cited by this paper
• Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells.

  1995cited by this paper
• A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice

  1995cited by this paper
• p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency.

  1995cited by this paper
• Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo.

  1995cited by this paper
• High-frequency developmental abnormalities in p53-deficient mice.

  1995cited by this paper
• Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

  1995cited by this paper
• The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice

  1994cited by this paper
• Tumor spectrum analysis in p53-mutant mice.

  1994cited by this paper
• Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.

  1994cited by this paper
• p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

  1994cited by this paper
• p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

  1994cited by this paper
• p53-dependent apoptosis in vivo: impact of p53 inactivation on tumorigenesis.

  1994cited by this paper
• DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

  1994cited by this paper
• The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

  1994cited by this paper
• Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

  1994cited by this paper
• Role of apoptosis in mediating phosphoramide mustard-induced rat embryo malformations in vitro.

  1994cited by this paper
• Activation of apoptosis in early mouse embryos by 2'-deoxyadenosine exposure.

  1994cited by this paper
• Mediation of c-Myc-induced apoptosis by p53.

  1994cited by this paper
• p53-mediated cell death: relationship to cell cycle control

  1993cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

  1993cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• Amplification of a gene encoding a p53-associated protein in human sarcomas

  1992cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud.

  1992cited by this paper
• Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

  1992cited by this paper
• Effects of (R)-deoxycoformycin (pentostatin) on intrauterine nucleoside catabolism and embryo viability in the pregnant mouse.

  1992cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• p53 mutations in human cancers.

  1991cited by this paper
• Expression of p53 during mouse embryogenesis.

  1991cited by this paper
• Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.

  1990cited by this paper
• Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells.

  1989cited by this paper
• Teratogens and craniofacial malformations: relationships to cell death.

  1988cited by this paper
• p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors

  1985cited by this paper
• Cyclophosphamide teratogenesis: a review.

  1985cited by this paper
• Atlas of embryonic development

  1984cited by this paper
• Ocular anatomy, embryology, and teratology

  1982cited by this paper
• Is compensatory growth a complicating factor in mouse teratology?

  1979cited by this paper
• Ocular malformations induced by radiation of the mouse embryo. A histopathological study with a particular view to stage specificity.

  1976cited by this paper
• Exposure-rate response in the prenatally irradiated rat: effects of 100 R on day 11 of gestation to the developing eye.

  1972cited by this paper
• The House Mouse: Atlas of Embryonic Development

  1972cited by this paper
• Mechanism of radiation anencephaly, anophthalmia, and pituitary anomalies; repair in the mammalian embryo.

  1954cited by this paper

• Recurrent Pregnancy Loss

  2025cites this paper
• Maternal Immune Stimulation With Interferon‐Gamma Limits Embryonic Valproic Acid Induced Apoptotic Gene Expression

  2025cites this paper
• SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

  2023cites this paper
• Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses

  2022cites this paper
• Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish.

  2021cites this paper
• Trichostatin A mitigates radiation induced teratogenesis in C57 Bl/6 mice.

  2021cites this paper
• Genotoxic and mutagenic studies of teratogens in developing rat and mouse

  2019cites this paper
• The Roles of P53 and Its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis-Stage Mouse Embryos

  2018cites this paper
• Hydroxyurea embryotoxicity is enhanced in P53-deficient mice.

  2018cites this paper
• Editor's Highlight: Hydroxyurea Exposure Activates the P53 Signaling Pathway in Murine Organogenesis-Stage Embryos.

  2016cites this paper
• Dose-dependent teratogenicity of the synthetic cannabinoid CP-55,940 in mice.

  2016cites this paper
• Thalidomide (5HPP-33) suppresses microtubule dynamics and depolymerizes the microtubule network by binding at the vinblastine binding site on tubulin.

  2015cites this paper
• Impact of Oxidative Stress on Development

  2014cites this paper
• Intrinsic Apoptosis Pathway in Fallopian Tube Epithelial Cells Induced by Cladribine

  2014cites this paper
• G 1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p 53 target

  2013cites this paper
• Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovarian surface epithelial cells of cladribine-treated rats

  2013cites this paper
• Differential programming of p53-deficient embryonic cells during rotenone block.

  2011cites this paper
• Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype

  2010cites this paper
• Mechanisms of the embryo's response to embryopathic stressors: a focus on p53.

  2010cites this paper
• Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits.

  2010cites this paper
• Sensitivity to cadmium-chloride-induced forelimb ectrodactyly is independent of the p53 gene-dosage in the C57BL/6J mouse.

  2010cites this paper
• The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos

  2009influential citation
• The roles of p53 and p21 in normal development and hyperthermia-induced malformations.

  2009cites this paper
• Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer.

  2009cites this paper
• Study of the physiological function of three putative modifiers of the p53 pathway: Nucleostemin, Ptprv and TCTP

  2008cites this paper
• Research Article: Expression pattern of deoxyguanosine kinase3 during mouse development

  2007cites this paper
• Does the maternal immune system regulate the embryo's response to teratogens?

  2007cites this paper
• p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-kappaB DNA binding.

  2007cites this paper
• Expression of apoptosis-associated molecules in the fetoplacental unit of cyclophosphamide-treated mice.

  2006cites this paper
• DNA repair disorders causing malformations.

  2005cites this paper
• Teratogen-induced apoptotic cell death: does the apoptotic machinery act as a protector of embryos exposed to teratogens?

  2005cites this paper
• G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

  2005cites this paper
• Improving Predictive Modeling in Pediatric Drug Development: Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling

  2005cites this paper
• Gene–Environment Interactions: A Review of Effects on Reproduction and Development

  2004cites this paper
• SCIENTIFIC DISCUSSION This module reflects the initial scientific discussion for the approval of Litak. For information on changes after approval please refer to module 8. 1 Introduction LITAK contains the active substance cladribine (2-chloro-2’-deoxy- -D-adenosine or 2-chloro-6- amino-9-(2-deoxy-

  2004cites this paper
• Hypoglycemia induced changes in cell death and cell proliferation in the organogenesis stage embryonic mouse heart.

  2004cites this paper
• How good is our genome?

  2004cites this paper
• TNF-alpha protects embryos exposed to developmental toxicants.

  2003cites this paper
• Modulation of p53 after maternal exposure to all-trans-retinoic acid in Swiss Webster mouse fetuses.

  2003cites this paper
• TNF-α in Pregnancy Loss and Embryo Maldevelopment: A Mediator of Detrimental Stimuli or a Protector of the Fetoplacental Unit?

  2003cites this paper
• Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195.

  2003cites this paper
• The p53-Mdm2 pathway: targets for the development of new anticancer therapeutics.

  2003cites this paper
• TNF‐α Protects Embryos Exposed to Developmental Toxicants

  2003cites this paper
• Transcription Factor Gene AP-2γ Essential for Early Murine Development

  2002cites this paper
• Radiation-Induced Teratogenic Effects in Fetal Mice with Varying Trp53 Function: Influence of Prior Heat Stress

  2002cites this paper
• Glutathione and p53 independently mediate responses against oxidative stress in ES cells.

  2002cites this paper
• DNA repair during organogenesis.

  2002cites this paper
• The Role of Pro‐ and Anti‐apoptotic Molecular Interactions in Embryonic Maldevelopment

  2002cites this paper
• Transcription factor gene AP-2 gamma essential for early murine development.

  2002cites this paper
• Health consequences after irradiation in utero – human data . Risk of leukemia and mental retardation

  2002cites this paper
• Intraocular teratoma in a mouse.

  2002cites this paper
• HSP90alpha, HSP90beta, and p53 expression following in vitro hyperthermia exposure in gestation day 10 rat embryos.

  2002cites this paper
• Exposure-disease continuum for 2-chloro-2'-deoxyadenosine (2-CdA), a prototype teratogen: induction of lumbar hernia in the rat and species comparison for the teratogenic responses.

  2002cites this paper
• Transcription Factor Gene AP-2 (cid:2) Essential for Early Murine Development

  2002cites this paper
• Threshold effect for teratogenic risk of radiation depends on dose-rate and p53 -dependent apoptosis

  2001cites this paper
• Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 1. Dose-response analysis.

  2001cites this paper
• Overview of Teratology

  2000cites this paper
• Mitochondrial transduction of teratogenesis.

  2000cites this paper
• Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos.

  2000cites this paper
• Biologically based risk assessment models for developmental toxicity.

  2000cites this paper
• Prenatal Radiation-Induced Limb Defects Mediated by Trp53-Dependent Apoptosis in Mice

  2000cites this paper
• Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo.

  1999cites this paper
• p53 in embryonic development: maintaining a fine balance

  1999cites this paper
• p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53

  1999cites this paper
• 2’-Deoxyadenosine causes cell death in embryonic chicken sympathetic ganglia and brain

  1999cites this paper
• Cellular events and the pattern of p53 protein expression following cyclophosphamide-initiated cell death in various organs of developing embryo.

  1999cites this paper
• Heat shock during rat embryo development in vitro results in decreased mitosis and abundant cell death.

  1999cites this paper
• Chapter 10 – Transgenic Animal Models: Functional Analysis of Developmental Toxicity as Illustrated with the p53 Suppressor Model

  1998cites this paper
• Apoptosis in embryos of diabetic rats.

  1998cites this paper
• Altered expression of mitochondrial 16S ribosomal RNA in p53-deficient mouse embryos revealed by differential display.

  1998cites this paper
• Reactive oxygen species and DNA oxidation in fetal rat tissues.

  1998cites this paper
• The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations.

  1998influential citation
• Transgenic Animal Models

  1998cites this paper
• Genetically engineered mice demonstrate that adenosine deaminase is essential for early postimplantation development.

  1997cites this paper
• Oxidative damage in chemical teratogenesis.

  1997cites this paper
• Risk assessment of environmental agents for developmental toxicity: current and emerging approaches.

  1997cites this paper
• Tumor suppressors: a developing role for p53?

  1997cites this paper
• Transgenic mouse model for studying the transcriptional activity of the p53 protein: age‐ and tissue‐dependent changes in radiation‐induced activation during embryogenesis

  1997cites this paper
• Tumour suppressors: A developing role for p53?

  1997cites this paper
• Nucleotide Pool Imbalance

  1997cites this paper
• Biochemical toxicology of chemical teratogenesis.

  1996cites this paper
• Flow cytometric detection of apoptosis

  1996cites this paper
• The p53-deficient mouse: a model for basic and applied cancer studies.

  1996cites this paper
• The p53 response to ionising radiation in adult and developing murine tissues.

  1996cites this paper
• Fluoroscopy: Radiation Protection of the Eye

  year unknowncites this paper