Might Cortical Hyper-Responsiveness in Aging Contribute to Alzheimer’s Disease?

Our goal is to understand the neural basis of functional impairment in aging and Alzheimer’s disease (AD) to be able to characterize clinically significant decline and assess therapeutic efficacy. We used frequency-tagged ERPs to word and motion stimuli to study the effects of stimulus conditions and selective attention. ERPs to word or motion increase when a task-irrelevant 2nd stimulus is added, but decrease when the task is moved to that 2nd stimulus. Spectral analyses show task effects on response power without 2nd stimulus effects. However, phase coherence shows both 2nd stimulus and task effects. Thus, power and coherence are dissociably modulated by stimulus and task effects. Task-dependent phase coherence successively declines in aging and AD. In contrast, task-dependent spectral power increases in aging, only to decrease in AD. We hypothesize that age-related declines in signal coherence, associated with increased power generation, stresses neurons and contributes to the loss of response power and the development of functional impairment in AD.

• Publication year

  2014

• Venue

  PLoS ONE

• Publication date

  2014-09-10

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1371/journal.pone.0105962PMID 25208332PMCID 4160186
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
• The normalization model of attention.

  2009cited by this paper
• High-Frequency, Long-Range Coupling Between Prefrontal and Visual Cortex During Attention

  2009cited by this paper
• On the origin of event-related potentials indexing covert attentional selection during visual search.

  2009cited by this paper
• The adaptive brain: aging and neurocognitive scaffolding.

  2009cited by this paper
• Entrainment of Neuronal Oscillations as a Mechanism of Attentional Selection

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• Event-related phase reorganization may explain evoked neural dynamics.

  2007cited by this paper
• Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer’s disease patients’ brain regions

  2007cited by this paper
• Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing.

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
• Functional activation imaging in aging and dementia.

  2005cited by this paper
• Attentional systems in target and distractor processing: a combined ERP and fMRI study

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• Mining event-related brain dynamics.

  2004cited by this paper
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  2004cited by this paper
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• Neural correlates of object-based attention.

  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Attention and executive deficits in Alzheimer's disease. A critical review.

  1999cited by this paper
• Striation is the characteristic neuritic abnormality in Alzheimer disease.

  1998cited by this paper
• Visual attention mediated by biased competition in extrastriate visual cortex.

  1998cited by this paper
• Sensory gain control (amplification) as a mechanism of selective attention: electrophysiological and neuroimaging evidence.

  1998cited by this paper
• ERP modulations indicate the selective processing of visual stimuli as a result of transient and sustained spatial attention.

  1996cited by this paper
• Disorders of Visual and Spatial Perception in the Early Stage of Alzheimer's Disease

  1996cited by this paper
• Selective attention to stimulus location modulates the steady-state visual evoked potential.

  1996cited by this paper
• Electrophysiological correlates of feature analysis during visual search.

  1994cited by this paper
• 'What' and 'where' in the human brain.

  1994cited by this paper
• Separate neural pathways for the visual analysis of object shape in perception and prehension.

  1994cited by this paper
• Separate visual pathways for perception and action.

  1992cited by this paper
• Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported.

  1989cited by this paper
• [Clinical diagnosis of Alzheimer's disease].

  1988cited by this paper
• P300 and anticipated task difficulty.

  1987cited by this paper
• Clinical diagnosis of Alzheimer's disease

  1984cited by this paper
• Two cortical visual systems

  1982cited by this paper
• “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician

  1975cited by this paper
• Excitability and inhibitability of motoneurons of different sizes.

  1965cited by this paper
• A standardized road-map test of direction sense

  1965cited by this paper

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