Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2011-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2010.12.093PMID 21236667
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease

  2011cited by this paper
• Attenuation of beta-amyloid-induced neuroinflammation by KHG21834 in vivo.

  2010cited by this paper
• Synthesis and evaluation of a library of 2,5-bisdiamino-benzoquinone derivatives as probes to modulate protein-protein interactions in prions.

  2010cited by this paper
• Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents.

  2010cited by this paper
• Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound.

  2010cited by this paper
• Strategies for the Inhibition of Protein Aggregation in Human Diseases

  2010cited by this paper
• Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.

  2009cited by this paper
• Reassessing the amyloid cascade hypothesis of Alzheimer's disease.

  2009cited by this paper
• MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.

  2009cited by this paper
• Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

  2009cited by this paper
• Alzheimer's disease: new approaches to drug discovery.

  2009cited by this paper
• Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.

  2008cited by this paper
• Curcumin‐Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

  2008cited by this paper
• Multi-target-directed ligands to combat neurodegenerative diseases.

  2008cited by this paper
• Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.

  2007cited by this paper
• Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.

  2007cited by this paper
• Insight Into the Kinetic of Amyloid β (1–42) Peptide Self‐Aggregation: Elucidation of Inhibitors’ Mechanism of Action

  2007cited by this paper
• Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.

  2007cited by this paper
• A small molecule targeting the multifactorial nature of Alzheimer's disease.

  2007cited by this paper
• Protective effect of benzothiazole derivative KHG21834 on amyloid beta-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons.

  2007cited by this paper
• Dimeric and hybrid anti-Alzheimer drug candidates.

  2006cited by this paper
• One‐compound‐multiple‐targets strategy to combat Alzheimer's disease

  2005cited by this paper
• Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B

  2004cited by this paper
• Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

  2004cited by this paper
• Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.

  2004cited by this paper
• 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.

  2003cited by this paper
• A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

  2002cited by this paper
• Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.

  2001cited by this paper
• Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.

  1999cited by this paper

• Total Synthesis of Nocarterphenyl A

  2025cites this paper
• Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

  2024cites this paper
• Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights

  2023cites this paper
• Novel Coumarin–Pyridine Hybrids as Potent Multi-Target Directed Ligands Aiming at Symptoms of Alzheimer’s Disease

  2022cites this paper
• Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease

  2021cites this paper
• RECENT ADVANCES INPHARMACOTHERAPY OF ALZHEIMER’S DISEASE

  2021cites this paper
• Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease

  2021cites this paper
• Liposomes Decorated with 2-(4'-Aminophenyl)benzothiazole Effectively Inhibit Aβ1-42 Fibril Formation and Exhibit in Vitro Brain-Targeting Potential.

  2020cites this paper
• Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors.

  2020cites this paper
• p-Benzoquinone a privileged scaffold of pharmacological significance: A review.

  2020cites this paper
• Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease.

  2019cites this paper
• Molecular Docking and Recent Advances in the Design and Development of Cholinesterase Inhibitor Scaffolds: Coumarin Hybrids

  2019cites this paper
• Cholinesterase and carboxylesterase inhibitors as pharmacological agents

  2019cites this paper
• Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues

  2018influential citation
• Designing Hybrids Targeting the Cholinergic System by Modulating the Muscarinic and Nicotinic Receptors: A Concept to Treat Alzheimer’s Disease

  2018cites this paper
• Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

  2018cites this paper
• Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease

  2018cites this paper
• Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.

  2018cites this paper
• Advances in Multi-Functional Ligands and the Need for Metal-Related Pharmacology for the Management of Alzheimer Disease

  2018cites this paper
• Several targets involved in Alzheimer’s disease amyloidogenesis are affected by morin and isoquercitrin

  2018cites this paper
• In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold.

  2018cites this paper
• Protocol for fast screening of multi-target drug candidates: Application to Alzheimer's disease.

  2017cites this paper
• Medicinal Chemistry of Hybrids for Neurodegenerative Diseases

  2017cites this paper
• Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs.

  2017cites this paper
• Physicochemical Properties for Potential Alzheimer’s Disease Drugs

  2017cites this paper
• Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease.

  2017cites this paper
• Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

  2017cites this paper
• Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress

  2017cites this paper
• Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation.

  2017cites this paper
• Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

  2016cites this paper
• Coumarins as cholinesterase inhibitors: A review.

  2016cites this paper
• A Review on Current Strategies and Future Perspective in Respect to Alzheimer's Disease Treatment

  2016cites this paper
• 8‐Aminomethyl‐7‐hydroxy‐4‐methylcoumarins as Multitarget Leads for Alzheimer's Disease

  2016cites this paper
• Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.

  2016influential citation
• Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.

  2016cites this paper
• Alzheimer’s Disease Management: Current Therapy and Recent Drug Development

  2016cites this paper
• RECENT ADVANCES IN ALZHEIMER'S DISEASE: CAUSES AND TREATMENT

  2016cites this paper
• Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease.

  2016cites this paper
• Enzymes Inhibitors: Food and Non‐Food Impacts

  2015cites this paper
• Computer-Aided Structure-Based Design of Multitarget Leads for Alzheimer's Disease

  2015cites this paper
• Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease.

  2015cites this paper
• Bioanalytical Approach to the Interaction of Novel sym-Triazine Derivatives with Alzheimer ’ s disease biomarkers

  2015cites this paper
• MTDLs Design on AChE (Acetylcholinesterase) and β-Secretase (BACE-1): 3D-QSAR and Molecular Docking Studies

  2015cites this paper
• Neurodegenerative diseases – Understanding their molecular bases and progress in the development of potential treatments

  2015cites this paper
• Bioanalytical approach to the interaction of novel sym-triazine derivatives with Alzheimer's disease biomarkers

  2015cites this paper
• Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease

  2014cites this paper
• Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.

  2014cites this paper
• Iron chelating strategies in systemic metal overload, neurodegeneration and cancer.

  2014cites this paper
• Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

  2014cites this paper
• Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

  2014cites this paper
• Nitro-methyl redox coupling: efficient approach to 2-hetarylbenzothiazoles from 2-halonitroarene, methylhetarene, and elemental sulfur.

  2013cites this paper
• Development of a neuroprotective antioxidant by a mix-and-match strategy -

  2013cites this paper
• Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.

  2013cites this paper
• Advances in electrochemical detection for study of neurodegenerative disorders

  2013cites this paper
• Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.

  2013cites this paper
• The benzazole scaffold: a SWAT to combat Alzheimer's disease.

  2013cites this paper
• Design, synthesis and biological activity of multifunctional α,β-unsaturated carbonyl scaffolds for Alzheimer's disease.

  2013cites this paper
• The multifactorial nature of Alzheimer's disease for developing potential therapeutics.

  2013cites this paper
• New treatment strategies for Alzheimer's disease: is there a hope?

  2013cites this paper
• Curcumin: a natural substance with potential efficacy in Alzheimer’s disease

  2013cites this paper
• Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

  2013cites this paper
• Rationally designed multi-targeted agents against neurodegenerative diseases.

  2013cites this paper
• Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates.

  2013cites this paper
• Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

  2013cites this paper
• Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

  2013cites this paper
• Drugs for Alzheimer's

  2012cites this paper
• Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

  2012cites this paper
• The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

  2012cites this paper
• Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

  2012cites this paper
• Designed multiple ligands: basic research vs clinical outcomes.

  2012cites this paper
• Cognitive Enhancers in Moderate to Severe Alzheimer's Disease:

  2011cites this paper
• The use of multi-target drugs in the treatment of neurodegenerative diseases

  2011cites this paper
• Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.

  2011cites this paper
• Exploration of Novel Ureidobenzothiazole Library Against Neuroinflammation

  2011cites this paper